DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lac and LOC100496188

DIOPT Version :9

Sequence 1:NP_523713.2 Gene:Lac / 36363 FlyBaseID:FBgn0010238 Length:359 Species:Drosophila melanogaster
Sequence 2:XP_031748713.1 Gene:LOC100496188 / 100496188 -ID:- Length:852 Species:Xenopus tropicalis


Alignment Length:316 Identity:71/316 - (22%)
Similarity:117/316 - (37%) Gaps:73/316 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    87 LRYD-------PNSS---------TYKLQIKDIQETDAGTYTCQVVIS--TVHKVSAEVKLSVRR 133
            ||||       |..|         ...|.:.::..:|.|||.|.|:.|  |..|   |::|.:..
 Frog    73 LRYDNKGKVSSPRVSIDERALLEGNASLSLSNVTVSDGGTYRCSVIYSPETQKK---EIRLRIHA 134

  Fly   134 -PPVISDNSTQSVVASEGSEVQMECYASG-YPTP-TITWRRENNAILP----------TDSATYV 185
             |.|:.  :.:::|.::|:  .:.|..:. ||.. |:||.| |..:||          .|....:
 Frog   135 LPEVVV--AKRTLVRNQGT--ALRCSVTDFYPQRITVTWLR-NGKVLPNSALGPLQQNADGTFRL 194

  Fly   186 GNTLRIKSVKKEDRGTYYCVADNGVSKGDRR-NINVEVEFAPVITVPRPRL-GQALQYDMDLECH 248
            .:||.:.....||.....|:..:......|| :..|:....|.:.|...:: |:..|.   |.|.
 Frog   195 NSTLTLTPSDTEDTPEIACLVQHESLPTPRRDSFRVQYGVPPSVQVYSAKINGRPEQV---LVCE 256

  Fly   249 IEAYPPP--AIVW-----TKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQYGDYVCKAT 306
            ...:.|.  .|.|     ..:|::.:.:     ..|.|...|..:....|     |.|:..|.. 
 Frog   257 ASQFQPEPVRIQWLLNGKIPEDLKKSRD-----GGFKTGSYYVINPTGGI-----QVGNISCAV- 310

  Fly   307 NRFGEAEARVNLFETIIPVCPPACGQAYIAGAEDVSATSFALV-----GILAALLF 357
                |.|..:......:.:.|......|.||  :::|..|..:     ||.|.|.|
 Frog   311 ----EHETLLLPITETLQLSPEDTEAKYSAG--NIAAAIFLTMLLMGAGITAGLWF 360

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LacNP_523713.2 IG_like 36..131 CDD:214653 18/61 (30%)
FR1 37..50 CDD:409353
Ig strand A' 37..42 CDD:409353
Ig strand B 44..51 CDD:409353
CDR1 51..59 CDD:409353
Ig strand C 59..63 CDD:409353
FR2 60..63 CDD:409353
CDR2 67..81 CDD:409353
Ig strand C' 68..72 CDD:409353
Ig strand C' 79..81 CDD:409353
FR3 84..115 CDD:409353 12/43 (28%)
Ig strand D 84..90 CDD:409353 2/2 (100%)
Ig strand E 94..102 CDD:409353 2/16 (13%)
Ig strand F 108..115 CDD:409353 4/6 (67%)
CDR3 116..124 CDD:409353 3/9 (33%)
FR4 124..130 CDD:409353 1/5 (20%)
Ig strand G 124..130 CDD:409353 1/5 (20%)
Ig_3 134..208 CDD:404760 20/85 (24%)
Ig strand B 153..157 CDD:409353 0/3 (0%)
Ig strand C 166..170 CDD:409353 2/3 (67%)
Ig strand E 187..191 CDD:409353 2/3 (67%)
Ig strand F 201..206 CDD:409353 1/4 (25%)
Ig strand G 215..218 CDD:409353 2/3 (67%)
Ig 227..318 CDD:416386 18/98 (18%)
Ig strand C 256..260 CDD:409353 2/8 (25%)
Ig strand E 286..290 CDD:409353 0/3 (0%)
Ig strand F 300..305 CDD:409353 1/4 (25%)
LOC100496188XP_031748713.1 V-set 30..133 CDD:400157 18/62 (29%)
Ig strand B 41..48 CDD:409353
CDR1 49..58 CDD:409353
FR2 60..70 CDD:409353
Ig strand C 60..67 CDD:409353
Ig strand C' 76..79 CDD:409353 1/2 (50%)
FR3 82..117 CDD:409353 8/34 (24%)
Ig strand D 85..91 CDD:409353 1/5 (20%)
Ig strand E 97..103 CDD:409353 1/5 (20%)
Ig strand A 136..143 CDD:409353 2/8 (25%)
Ig strand B 150..160 CDD:409353 2/11 (18%)
C1-set 153..220 CDD:400140 16/67 (24%)
Ig strand C 165..171 CDD:409353 3/5 (60%)
Ig strand C' 173..176 CDD:409353 0/2 (0%)
Ig strand D 180..187 CDD:409353 0/6 (0%)
Ig strand E 190..200 CDD:409353 2/9 (22%)
Ig strand F 210..217 CDD:409353 1/6 (17%)
Ig 234..315 CDD:416386 19/98 (19%)
Ig strand A 235..242 CDD:409353 2/6 (33%)
Ig strand B 251..258 CDD:409353 3/9 (33%)
Ig strand C 264..270 CDD:409353 1/5 (20%)
Ig strand C' 273..275 CDD:409353 0/1 (0%)
Ig strand E 287..295 CDD:409353 3/7 (43%)
Ig strand F 302..312 CDD:409353 3/14 (21%)
IgC1 <617..702 CDD:409354
Ig strand C 628..632 CDD:409354
Ig strand E 669..673 CDD:409354
Ig strand F 684..689 CDD:409354
Ig strand G 699..702 CDD:409354
Ig 701..804 CDD:416386
Ig strand B 712..729 CDD:409353
Ig strand C 734..741 CDD:409353
Ig strand C' 750..753 CDD:409353
Ig strand E 766..781 CDD:409353
Ig strand F 789..795 CDD:409353
Ig strand G 798..804 CDD:409353
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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