DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and dscam

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	XP_031751619.1	Gene:	dscam / 100216449	XenbaseID:	XB-GENE-921689	Length:	2039	Species:	Xenopus tropicalis

Alignment Length:	413	Identity:	94/413 - (22%)
Similarity:	141/413 - (34%)	Gaps:	155/413 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RTP-TISYITQEQIKDIGGTVEFDCSVQYAKEYNVLFLKTDSDPVFLSTGSTLVIKDSRFSLRYD 90
            |.| |:....|:.::  |..|.|.|.:..:.|..|..:..:.|.|.|.:||..:|
Frog   123 REPYTVRVDDQKAMR--GNAVVFKCIIPSSVEAYVTVVSWEKDTVSLVSGSRFLI---------- 175

  Fly    91 PNSSTYKLQIKDIQETDA-GTYTCQVVISTVHKVSAEVKLSVRRPPVISD--NSTQSVV------ 146
              :||..|.|.|:|..|. ..|.|    :|.||.:.|.:.|......:||  ||..|::
Frog   176 --TSTGALYIADVQNEDGLNNYRC----TTRHKYTGETRQSNSARLTVSDPANSAPSIIDGFEHH 234

  Fly   147 -ASEGSEVQMECYASGYPTPTITWRRENNAIL-------------------PTDSATYV------ 185
             |..|..|::.|.|||:|.|...|.: ||.:|                   |:||.:||
Frog   235 KAMAGERVELPCKASGHPIPKYRWLK-NNVLLEPDSRFQHTVVGLLIENTRPSDSGSYVCEVWNN 298

  Fly   186 ----------------------------------------------------------GNTLRIK 192
                                                                      ||.:||.
Frog   299 YGNAEVIGSLYVKQPLKVNISPRKVKSSVGSQISLACSVTGTDDPDLSWYRNGEIINAGNNVRIT 363

  Fly   193 SVKKE----------DRGTYYC---------------VADNGVSKGDRRNINVEVEFAPVITVPR 232
            .|.:|          |.|.|.|               |.::|..|       :...|:..:..|
Frog   364 GVNRETLIMDGMAKSDSGAYQCFVRREKMSAQDYVQVVLEDGTPK-------IISAFSEKVVSP- 420

  Fly   233 PRLGQALQYDMDLECHIEAYPPPAIVWTKDDIQLANNQHYSISHFATADEYTDSTLRVITVEKRQ 297
               |:    .:.|.|:::..|.|.|.||.||..:..|.::.||...|::....|.|.:...:.|.
Frog   421 ---GE----PVSLMCNVKGTPLPTITWTLDDDPIIKNGNHRISQLITSEGNVVSYLNITNTQVRD 478

  Fly   298 YGDYVCKATNRFGEA--EARVNL 318
            .|.|.|.|.|..|..  :||:|:
Frog   479 GGVYRCTANNSAGVVLYQARINV 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	26/95 (27%)
		FR1	37..50	CDD:409353	3/12 (25%)
		Ig strand A'	37..42	CDD:409353	0/4 (0%)
		Ig strand B	44..51	CDD:409353	2/6 (33%)
		CDR1	51..59	CDD:409353	1/7 (14%)
		Ig strand C	59..63	CDD:409353	1/3 (33%)
		FR2	60..63	CDD:409353	1/2 (50%)
		CDR2	67..81	CDD:409353	5/13 (38%)
		Ig strand C'	68..72	CDD:409353	2/3 (67%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	9/31 (29%)
		Ig strand D	84..90	CDD:409353	0/5 (0%)
		Ig strand E	94..102	CDD:409353	4/7 (57%)
		Ig strand F	108..115	CDD:409353	2/7 (29%)
		CDR3	116..124	CDD:409353	3/7 (43%)
		FR4	124..130	CDD:409353	1/5 (20%)
		Ig strand G	124..130	CDD:409353	1/5 (20%)
		Ig_3	134..208	CDD:404760	34/190 (18%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	0/3 (0%)
		Ig strand E	187..191	CDD:409353	1/3 (33%)
		Ig strand F	201..206	CDD:409353	2/19 (11%)
		Ig strand G	215..218	CDD:409353	0/2 (0%)
		Ig	227..318	CDD:416386	26/92 (28%)
		Ig strand C	256..260	CDD:409353	1/3 (33%)
		Ig strand E	286..290	CDD:409353	2/3 (67%)
		Ig strand F	300..305	CDD:409353	2/4 (50%)
dscam	XP_031751619.1	Ig	26..121	CDD:416386
		Ig strand A'	33..37	CDD:409353
		Ig strand B	40..49	CDD:409353
		Ig strand C	55..61	CDD:409353
		Ig strand C'	63..66	CDD:409353
		Ig strand D	72..75	CDD:409353
		Ig strand E	80..85	CDD:409353
		Ig strand F	98..106	CDD:409353
		Ig strand G	109..121	CDD:409353
		Ig	124..217	CDD:416386	29/110 (26%)
		Ig strand A'	127..136	CDD:409353	2/8 (25%)
		Ig strand B	140..147	CDD:409353	3/6 (50%)
		Ig strand C	157..162	CDD:409353	0/4 (0%)
		Ig strand C'	164..167	CDD:409353	1/2 (50%)
		Ig strand D	172..176	CDD:409353	1/15 (7%)
		Ig strand E	179..185	CDD:409353	2/5 (40%)
		Ig strand F	193..201	CDD:409353	3/11 (27%)
		Ig strand G	205..217	CDD:409353	2/11 (18%)
		Ig strand A	225..228	CDD:409353	1/2 (50%)
		Ig strand A'	234..237	CDD:409353	0/2 (0%)
		IG_like	236..310	CDD:214653	18/74 (24%)
		Ig strand B	242..249	CDD:409353	2/6 (33%)
		Ig strand C	255..260	CDD:409353	1/4 (25%)
		Ig strand C'	262..264	CDD:409353	1/1 (100%)
		Ig strand D	270..274	CDD:409353	0/3 (0%)
		Ig strand E	276..280	CDD:409353	0/3 (0%)
		Ig strand F	289..297	CDD:409353	2/7 (29%)
		Ig strand G	300..310	CDD:409353	0/9 (0%)
		Ig	313..395	CDD:416386	10/81 (12%)
		Ig strand A	314..319	CDD:409353	0/4 (0%)
		Ig strand A'	322..326	CDD:409353	0/3 (0%)
		Ig strand B	329..339	CDD:409353	0/9 (0%)
		Ig strand C	344..350	CDD:409353	0/5 (0%)
		Ig strand C'	351..354	CDD:409353	0/2 (0%)
		Ig strand E	368..374	CDD:409353	1/5 (20%)
		Ig strand F	381..389	CDD:409353	3/7 (43%)
		Ig	406..501	CDD:416386	28/109 (26%)
		Ig strand A	406..409	CDD:409353	1/9 (11%)
		Ig strand A'	415..419	CDD:409353	0/3 (0%)
		Ig strand B	422..431	CDD:409353	2/12 (17%)
		Ig strand C	436..442	CDD:409353	3/5 (60%)
		Ig strand C'	444..447	CDD:409353	1/2 (50%)
		Ig strand D	452..460	CDD:409353	2/7 (29%)
		Ig strand E	464..473	CDD:409353	2/8 (25%)
		Ig strand F	480..488	CDD:409353	4/7 (57%)
		Ig strand G	491..501	CDD:409353	3/9 (33%)
		Ig	504..593	CDD:416386
		Ig strand A	505..507	CDD:409353
		Ig strand A'	512..516	CDD:409353
		Ig strand B	519..526	CDD:409353
		Ig strand C	533..539	CDD:409353
		Ig strand C'	540..542	CDD:409353
		Ig strand D	549..553	CDD:409353
		Ig strand E	557..563	CDD:409353
		Ig strand F	571..579	CDD:409353
		Ig strand G	583..593	CDD:409353
		Ig	596..686	CDD:416386
		Ig strand A	597..599	CDD:409353
		Ig strand A'	604..608	CDD:409353
		Ig strand B	611..620	CDD:409353
		Ig strand C	625..632	CDD:409353
		Ig strand C'	634..636	CDD:409353
		Ig strand D	643..648	CDD:409353
		Ig strand E	651..658	CDD:409353
Ig strand F	665..673	CDD:409353
Ig strand G	676..685	CDD:409353
Ig_DSCAM	689..784	CDD:409397
Ig strand B	707..711	CDD:409397
Ig strand C	720..724	CDD:409397
Ig strand E	749..753	CDD:409397
Ig strand F	763..768	CDD:409397
Ig strand G	777..780	CDD:409397
Ig_DSCAM	785..885	CDD:409398
Ig strand B	805..809	CDD:409398
Ig strand C	818..822	CDD:409398
Ig strand E	849..853	CDD:409398
Ig strand F	863..868	CDD:409398
Ig strand G	876..879	CDD:409398
FN3	886..980	CDD:238020
FN3	987..1084	CDD:238020
FN3	1093..1185	CDD:238020
FN3	1190..1279	CDD:238020
Ig_3	<1303..1364	CDD:404760
Ig strand B	1304..1311	CDD:409353
Ig strand C	1317..1322	CDD:409353
Ig strand C'	1327..1333	CDD:409353
Ig strand D	1337..1341	CDD:409353
Ig strand E	1343..1347	CDD:409353
Ig strand F	1356..1364	CDD:409353
Ig strand G	1367..1377	CDD:409353
FN3	1381..1471	CDD:238020
FN3	1497..1568	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910