DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lac and LOC100006764

DIOPT Version :9

Sequence 1:	NP_523713.2	Gene:	Lac / 36363	FlyBaseID:	FBgn0010238	Length:	359	Species:	Drosophila melanogaster
Sequence 2:	XP_001345427.5	Gene:	LOC100006764 / 100006764	-ID:	-	Length:	1565	Species:	Danio rerio

Alignment Length:	194	Identity:	40/194 - (20%)
Similarity:	71/194 - (36%)	Gaps:	47/194 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 KTDSDPVFLSTGSTLVIKDSRFSLRYDPNSSTYKLQIKDIQETDAGTYTCQVVISTVHKVSAEVK 128
            |....|.|..|       |.:|.|:.  |..|..|.:..:::||||.||.        |:|:..:
Zfish   178 KETKKPPFYDT-------DEKFRLQL--NDQTGSLTVNTMKDTDAGLYTV--------KISSNKQ 225

  Fly   129 LSVRRPPV------ISDNSTQSVVASEGSEVQMECYASGYPTPTITWRRENNAILPTDSATYVGN 187
            ::.::..|      :|..|...:|.     |.:..:..........:||:.:.:.........|.
Zfish   226 ITYKKFTVTVTGSGLSSESVAGIVV-----VLLLLFGVAAVLGFFIYRRKISELKKHQKHVQQGE 285

  Fly   188 TLRIKS---VKKEDR------GTYYCVADNGVSKGDRRNINVEVEFAPVITVPRPRLGQALQYD 242
            ::.::|   ::::|.      ..|..:|..|...|:.|.          ||.|..|.|..|..|
Zfish   286 SVTLESDTKIQRDDEIQWTFGDQYQLIAKMGKMTGETRE----------ITYPDERFGDRLYLD 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lac	NP_523713.2	IG_like	36..131	CDD:214653	18/66 (27%)
		FR1	37..50	CDD:409353
		Ig strand A'	37..42	CDD:409353
		Ig strand B	44..51	CDD:409353
		CDR1	51..59	CDD:409353
		Ig strand C	59..63	CDD:409353
		FR2	60..63	CDD:409353
		CDR2	67..81	CDD:409353	3/13 (23%)
		Ig strand C'	68..72	CDD:409353	1/3 (33%)
		Ig strand C'	79..81	CDD:409353	0/1 (0%)
		FR3	84..115	CDD:409353	11/30 (37%)
		Ig strand D	84..90	CDD:409353	2/5 (40%)
		Ig strand E	94..102	CDD:409353	2/7 (29%)
		Ig strand F	108..115	CDD:409353	4/6 (67%)
		CDR3	116..124	CDD:409353	1/7 (14%)
		FR4	124..130	CDD:409353	1/5 (20%)
		Ig strand G	124..130	CDD:409353	1/5 (20%)
		Ig_3	134..208	CDD:404760	12/88 (14%)
		Ig strand B	153..157	CDD:409353	1/3 (33%)
		Ig strand C	166..170	CDD:409353	0/3 (0%)
		Ig strand E	187..191	CDD:409353	0/3 (0%)
		Ig strand F	201..206	CDD:409353	1/4 (25%)
		Ig strand G	215..218	CDD:409353	1/2 (50%)
		Ig	227..318	CDD:416386	7/16 (44%)
		Ig strand C	256..260	CDD:409353
		Ig strand E	286..290	CDD:409353
		Ig strand F	300..305	CDD:409353
LOC100006764	XP_001345427.5	IG_like	27..122	CDD:214653
		Ig	33..122	CDD:299845
		Ig	142..230	CDD:299845	18/68 (26%)
		Ig	283..374	CDD:299845	15/67 (22%)
		Ig	387..478	CDD:299845
		Ig	504..584	CDD:299845
		Ig	607..686	CDD:299845
		Ig	703..783	CDD:299845
		Ig	791..894	CDD:299845
		Ig	915..991	CDD:299845
		Ig	1063..1153	CDD:299845
		IG_like	1156..1255	CDD:214653
		Ig	1163..1255	CDD:299845
		IG_like	1324..1420	CDD:214653
		Ig	1343..1422	CDD:299845
		IG_like	1425..1526	CDD:214653
		Ig	1444..1524	CDD:299845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910