DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyb and dtna

DIOPT Version :9

Sequence 1:	NP_001097287.1	Gene:	Dyb / 36362	FlyBaseID:	FBgn0033739	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_009295867.1	Gene:	dtna / 794932	ZFINID:	ZDB-GENE-070117-2	Length:	728	Species:	Danio rerio

Alignment Length:	779	Identity:	306/779 - (39%)
Similarity:	415/779 - (53%)	Gaps:	152/779 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RVAILQDLRLQTFDSIRFASYRTASKLRYIQKSTNLHLVDIWNVIEAFRENGLNTLEPQSEVSVA 70
            |..:..::|....||||.::||||.|||:|||..|||||||||:||.||||.||::|..:|.||:
Zfish    21 RRQLFAEMRALDLDSIRLSTYRTACKLRFIQKRCNLHLVDIWNIIEVFRENRLNSVELNTEFSVS 85

  Fly    71 RLETLVSSLYHNLNKRLPTAQQVPVDSKAGLLLNWLLAAYTSDNSGKIRVFSIKVALATMCSGKL 135
            .|:.::|:::..|||||||..|:.||.....|||:||.||..:..|||..|.:|:||||:|.||:
Zfish    86 HLQAILSTIFQQLNKRLPTTHQINVDQSISYLLNFLLTAYDQEGVGKISAFVMKMALATLCGGKI 150

  Fly   136 VDKLRYIFSQISDGAGQLVAWKLGEFLREVLALPAAVYESPTFHYKEGLEEEIFPAENKVTVNDF 200
            :||||||||||||..|.::..:..:||||||.:|.:|:|.|:|.|.|......||.|.|||:|.|
Zfish   151 LDKLRYIFSQISDPNGLMIYSQFDQFLREVLKVPVSVFEGPSFGYTEQSTRSCFPQEKKVTLNVF 215

  Fly   201 MATLMSEPGPSCLVWLPLVHRLATVETIVHPTVCSVCHKENFTGFRYRCQRCHAYQLCQECFWHG 265
            :.|.||:|.|.|||||||:||||.||.:.||..||.||.::..|||||||:|..|||||||||.|
Zfish   216 LDTFMSDPPPQCLVWLPLMHRLANVENVFHPVECSYCHSQSMMGFRYRCQQCDNYQLCQECFWRG 280

  Fly   266 KTSLNHQNDHEVKEYSSYKSPSKQIGHSLRKSFRCVPEKTVQVLPRFPDQPEKTLNLSHIV---P 327
            ..|.:|.|.|::|||.|:|||:|::..:|.||..|...:. ...|:|.|.|||||||:|||   |
Zfish   281 HASGSHSNQHQMKEYMSWKSPAKKLSDALSKSLSCAASRE-PAYPQFSDTPEKTLNLNHIVGTWP 344

  Fly   328 PSPLPSHNGFSDPSGLVHGHHGPHPGLP-----------GQHGLFDRSS--TLDSRATGRSLDSA 379
            |.|:.:.|.:      :..|..|..|.|           .|..||.|::  .|..:....|||.|
Zfish   345 PRPVATGNEY------MLSHSMPSSGNPYSSKASAHDETNQMKLFSRTTPDLLKGKGVQYSLDIA 403

  Fly   380 SGTAGTTM-------------SRVAAASAN-DEEHRLIARYAARL------AQENRAPSNLPDNA 424
            ...|...:             |....:|.| |:||.||||||:||      ||:.|.|:::
Zfish   404 DRLADEHILIGLYVNLLQKERSCFQHSSKNQDDEHCLIARYASRLAADEVAAQKGRVPTDI---- 464

  Fly   425 TPIGTDNSRAQRELIAQLESKNKEIMREIARLRRQQETEQMAP-----ENPALINELRALRQRKG 484
             .:..|:::.||:|||:||:|||||::||.|||:|.|.....|     :||.|:.|||.|||||.
Zfish   465 -SLCLDSNKQQRQLIAELENKNKEILQEIQRLRQQHEEASQPPLDKNQQNPMLLAELRLLRQRKE 528

  Fly   485 ELEGHLGALQDSRRQLMEQLEGLMRMLKNQQTASPRSTPNSSPRSGKSPPMPGGAGILGTSPMSA 549
            |||..:.|||:|||:||.|||.||.:||.::.......|..||||..|
Zfish   529 ELEQRMSALQESRRELMVQLEQLMLLLKEEELRRANQGPGPSPRSSPS----------------- 576

  Fly   550 LHAQQMQQHPMAGGVRASQQQLLQQQQQQAHGHGPFSQSQLEQLNQISSDMRSAFAANGSATPPP 614
                    |.::    ||.|.|                                   :|::||.|
Zfish   577 --------HTLS----ASVQSL-----------------------------------SGNSTPIP 594

  Fly   615 MRTTTATANVSAIPSLNPISN-------------QNPNLNPDAELNEAADHLTSAISHMVSDLNA 666
            |...:.:.|.:  ||..|..:             |....|..::|..|||.:|:.:|.:|.:||:
Zfish   595 MPVQSTSGNTT--PSQTPQDSLMGLGGEVQQAFAQGSRRNLRSDLLVAADSITNTMSSLVKELNS 657

  Fly   667 GRGRAQQLGPQPASSIPQARFIMP-LEFRHI-EGGESEDSSQCECNDCECGEYEEVFRTDEDLE 728
            ..|       ..::||  :.|:.| .:.||. ....|..:|:.|..|         |...||||
Zfish   658 EAG-------NESNSI--SDFMFPESDVRHTRSSSRSGAASKLEPGD---------FYGHEDLE 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyb	NP_001097287.1	EF-hand_2	7..131	CDD:286194	64/123 (52%)
		EF-hand_3	135..223	CDD:286195	48/87 (55%)
		ZZ_dystrophin	232..280	CDD:239074	27/47 (57%)
		Ribosomal_L29	436..482	CDD:279204	27/50 (54%)
dtna	XP_009295867.1	EF-hand_2	22..146	CDD:286194	64/123 (52%)
		EF-hand_3	150..238	CDD:286195	48/87 (55%)
		ZZ_dystrophin	247..295	CDD:239074	27/47 (57%)
		THOC7	<464..541	CDD:283305	38/81 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596354
Domainoid	1	1.000	172	1.000	Domainoid score	I3674
eggNOG	1	0.900	-	-		E1_KOG4301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	488	1.000	Inparanoid score	I1386
OMA	1	1.010	-	-		QHG49468
OrthoDB	1	1.010	-	-		D308769at33208
OrthoFinder	1	1.000	-	-		FOG0002910
OrthoInspector	1	1.000	-	-		otm26037
orthoMCL	1	0.900	-	-		OOG6_105554
Panther	1	1.100	-	-	LDO	PTHR12268
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17307
SonicParanoid	1	1.000	-	-		X2279
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.840