DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyb and dtna

DIOPT Version :9

Sequence 1:	NP_001097287.1	Gene:	Dyb / 36362	FlyBaseID:	FBgn0033739	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_031759299.1	Gene:	dtna / 779813	XenbaseID:	XB-GENE-6455225	Length:	755	Species:	Xenopus tropicalis

Alignment Length:	799	Identity:	307/799 - (38%)
Similarity:	415/799 - (51%)	Gaps:	158/799 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RVAILQDLRLQTFDSIRFASYRTASKLRYIQKSTNLHLVDIWNVIEAFRENGLNTLEPQSEVSVA 70
            |..:..::|.|..|.||.::||||.|||::||..|||||||||:|||.|||.||.::|..|::||
Frog    21 RRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNIIEALRENSLNNVDPNVELNVA 85

  Fly    71 RLETLVSSLYHNLNKRLPTAQQVPVDSKAGLLLNWLLAAYTSDNSGKIRVFSIKVALATMCSGKL 135
            |||.::|:::..||||:||..|:.|:....|:||:||.||.|:..|||.||::|:||||:|.||:
Frog    86 RLEAVLSTVFFQLNKRMPTTHQINVEQSISLMLNFLLTAYDSEGHGKITVFAVKMALATLCGGKI 150

  Fly   136 VDKLRYIFSQISDGAGQLVAWKLGEFLREVLALPAAVYESPTFHYKEGLEEEIFPAENKVTVNDF 200
            :||||||:|.|||..|.:|..:..:||||||.||.|::|.|:|.|.|......|..:.|||:|.|
Frog   151 MDKLRYIYSMISDTNGMMVYGRYDQFLREVLKLPTAIFEGPSFGYTEQAARSCFSQQKKVTLNSF 215

  Fly   201 MATLMSEPGPSCLVWLPLVHRLATVETIVHPTVCSVCHKENFTGFRYRCQRCHAYQLCQECFWHG 265
            :.||||:|.|.|||||||:||||.||.:.||..||.||.|:..|||||||:||.|||||:|||.|
Frog   216 LDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRG 280

  Fly   266 KTSLNHQNDHEVKEYSSYKSPSKQIGHSLRKSFRCVPEKTVQVLPRFPDQPEKTLNLSHIV---P 327
            ..|.:|.|.|::|||:|:|||:|::..:|.||..|...:. .:.|.|||||||.|||:|||   |
Frog   281 HASGSHSNQHQMKEYTSWKSPAKKLSTALSKSLSCASSRE-PLHPMFPDQPEKPLNLAHIVDTWP 344

  Fly   328 PSPLPSHNGFSDPSGLVHGHHGPHPGLPGQHGLFDRSST---------------LDSRATGRSLD 377
            |.|:.|.|      ..:..|..|..|.|..:.:....||               |..:....|||
Frog   345 PRPVTSMN------DNIFSHSVPCSGSPFTNKISPHKSTEVEQSKYLARAAPTLLKGKGLQYSLD 403

  Fly   378 SASGTAG-------------TTMSRVA-AASANDEEHRLIARYAARLAQENRAPSNLPDNATPIG 428
            .|...|.             ...||:. :.|..|||||||||||||||.||.:..........|.
Frog   404 VADRLADEHVLIGVYANMLQNNHSRMLDSPSRLDEEHRLIARYAARLAAENSSAQAQQRGGADIS 468

  Fly   429 --TDNSRAQRELIAQLESKNKEIMREIARLRRQQE-----TEQMAPENPALINELRALRQRKGEL 486
              .|.::.||:|||:||:||:||::||.|||.:.|     |.:.|.:||.|:.|||.|||||.||
Frog   469 FTIDANKQQRQLIAELENKNREILQEIQRLRIEHEQASQPTPEKAQQNPTLLAELRLLRQRKDEL 533

  Fly   487 EGHLGALQDSRRQLMEQLEGLMRMLKNQ---QTASPRSTPNSSPRSGKSPPMPGGAGILGTSPMS 548
            |..:.|||:|||:||.||||||::||.|   |......:|.|||....|.|:|        .|:.
Frog   534 EQRMSALQESRRELMVQLEGLMKLLKEQELRQETQGAGSPRSSPSHTISRPIP--------MPIR 590

  Fly   549 ALHAQQMQQHPMAGGVRASQQQLLQQQQQQAHGHGPFSQSQLEQLNQISSDMRSAFAANGSATPP 613
            :..|.....|                             :..:.|..:..|::.|||
Frog   591 SASACSTPTH-----------------------------TPQDSLTGVGGDVQEAFA-------- 618

  Fly   614 PMRTTTATANVSAIPSLNPISNQNPNLNPDAELNEAADHLTSAISHMVSDLNA------------ 666
                                  |:...|...:|..|||.:|:.:|.:|.:|.:
Frog   619 ----------------------QSARRNLRNDLLVAADSITNTMSSLVKELKSDVGNETECGVDT 661

  Fly   667 --GRGRAQQLGPQPASSIPQARFIMPLE-----FRH-------------IEGGESEDSSQCECND 711
              ||.....|.|.|.|   :..|:..:.     |.|             .||....       :|
Frog   662 EYGRVHFDDLVPSPTS---EKAFLAQIHARKPGFNHHSAATGNIRTDLGTEGSYGR-------HD 716

  Fly   712 CECGEYEEVFRTDEDLECE 730
            .|..|.:.|.:.:.:|:.|
Frog   717 DETYENDSVRQLEHELKME 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyb	NP_001097287.1	EF-hand_2	7..131	CDD:286194	65/123 (53%)
		EF-hand_3	135..223	CDD:286195	47/87 (54%)
		ZZ_dystrophin	232..280	CDD:239074	28/47 (60%)
		Ribosomal_L29	436..482	CDD:279204	26/50 (52%)
dtna	XP_031759299.1	EFh_DTNA	60..220	CDD:320007	82/159 (52%)
		ZZ_dystrophin	247..295	CDD:239074	28/47 (60%)
		PRK12704	442..>567	CDD:237177	65/124 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4006
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1264
OMA	1	1.010	-	-		QHG49468
OrthoDB	1	1.010	-	-		D308769at33208
OrthoFinder	1	1.000	-	-		FOG0002910
OrthoInspector	1	1.000	-	-		otm48182
Panther	1	1.100	-	-	LDO	PTHR12268
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2279
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080