DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyb and kst

DIOPT Version :9

Sequence 1:	NP_001097287.1	Gene:	Dyb / 36362	FlyBaseID:	FBgn0033739	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001097492.2	Gene:	kst / 38418	FlyBaseID:	FBgn0004167	Length:	4337	Species:	Drosophila melanogaster

Alignment Length:	858	Identity:	179/858 - (20%)
Similarity:	273/858 - (31%)	Gaps:	282/858 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 ASKLRYIQKSTNLHL-------VDIWNVIE---AFRENGLNTLEPQSEVSVARLETLVSSLYHNL 83
            |:||..|......|:       |:.|..::   |.|:|.|:..| |.:........|::.:...|
  Fly  3421 AAKLGEIYPDAKEHIEVKRDETVEAWTDLKEKTAARKNKLSQAE-QLQSYFDEYRDLIAWINEML 3484

  Fly    84 NKRLPTAQQVPVDSKAGLLLNWLLAAYTSDNSGKIRVFSIKVALATMCSGKLVDKLRYIFSQISD 148
            .|  .||.:: .:|.||.   .||.|.|.|:..:||......|.......:|:.:..::..::.|
  Fly  3485 AK--ITAPEL-ANSVAGA---ELLLASTKDHDTEIRTRDETFAKFAANGQQLIKEKHFLAHEVED 3543

  Fly   149 GAGQLVAWKLGEFLREVLALPAAVYESPTFHYKEGLEEEIFPAENKVTVNDFMATLMSEP----- 208
            ....|.|  ..|.|:..|.....:||.       .|:.::|..:.:: :..::::  .||
  Fly  3544 KIKVLQA--RHELLKHTLNKRREIYEL-------NLDTQLFLKDAEI-LEQWISS--REPQLKDT 3596

  Fly   209 --GPSCLVWLPLVHRLATVETIVHPTVCSVCHKENFTGFRYRCQRCHAYQLCQECFWHGKTSLNH 271
              |.|    :|.|..|.........||.:  .:|.|       |......:.::.|       .|
  Fly  3597 KLGDS----IPQVEDLLRRHEDFEKTVAA--QEEKF-------QAIKRITMLEQLF-------RH 3641

  Fly   272 QNDHEVKEYSSYKSPSKQIGHSLRKSFRCVPEKTVQV----LPRFPDQ----------------P 316
            |.:.|        ..||     |::..|...|:..|:    |.|..|:                .
  Fly  3642 QLEQE--------KISK-----LQEKERLEKERLEQLKQRELQRLADERRRAEKQHEHRQNAASQ 3693

  Fly   317 EKTLNLSHIVPPSPLPSHNGFSDPSGLVHGHHGPHPGLPGQHGLFDRSSTLDSRATGRSLDSASG 381
            |||...|   .|...|:.........|......|..|...:|....:|             |:||
  Fly  3694 EKTPIFS---SPMVTPAQTSGPQSPALSQVQLRPPFGDDNEHLALQKS-------------SSSG 3742

  Fly   382 TAGTTMSRVAAASANDEEHRLIARYAARLAQENRAPSNLPDNATPIGTDNSRAQRELIAQLESKN 446
            ..|..:.| .:|.||      :.|..:...|..:|      ..||..|...|||.      ..||
  Fly  3743 MFGDRLRR-GSADAN------VKRAESMKVQPKQA------KRTPSFTTRRRAQS------FRKN 3788

  Fly   447 K----------EIMREIARLRRQQETEQMAP---------------------ENPAL-------- 472
            :          ||...:.|....|...:.||                     ||..|
  Fly  3789 QKGEGFDLPPVEIQGSLERKHGLQSGGKKAPVRSWKQFHTVLCGQLVCFFKDENDFLQQKTATAP 3853

  Fly   473 INELRALRQRKGEL------------EG--------HLGALQDSRRQLM--------EQLEGLMR 509
            :|.|.|..:|..:.            :|        .|..|.|..|::.        .||.....
  Fly  3854 VNILGAKCERADDYTKKKYVFRLKLPDGSEFLFEAPSLDILNDWVRKISFHASLPPNMQLLSYDE 3918

  Fly   510 MLKNQQTASPR-----------STPNSSPRSGKSPPMPGGAGIL-GT-SPMSALHAQQMQQHPMA 561
            .:|.|.::||.           |:.||||.|.:   ...||.:| || :|..|...:||||
  Fly  3919 SMKQQSSSSPDIKVTSSVESPVSSRNSSPDSQR---RTSGAQVLDGTATPQMAFLQRQMQQ---- 3976

  Fly   562 GGVRASQQQLLQQQQQQA-----------------HGHGPFSQSQLEQLN-------QISSDMRS 602
                       ||||||:                 .|..|.:..:..|.|       |.|:|::.
  Fly  3977 -----------QQQQQQSQPSSPTGGFDQKPPIPPRGAAPVASHRQSQENLVVMRNRQSSNDLQQ 4030

  Fly   603 AFA-----------ANG---------------SATPPPMRTTTATANVSAIPSLNPISNQNPNLN 641
            :..           .||               |..|||:.||............|..|:||.:
  Fly  4031 SATLPAGLTGVQQNGNGKDDNALLTRNSEARQSDNPPPLPTTMPPVGGQHQHPQNSHSHQNQH-- 4093

  Fly   642 PDAELNEAADHLTSAIS--HMVSDLNAGRGRAQQLGPQ--PASSIPQARFIMPLEFRHIEGGESE 702
             .|::.:..:...:|.|  |.....|....|.|   ||  |:..|...|..:.:|..:..||.|.
  Fly  4094 -QAQVQQRINAFNAAASQQHQPDYFNNNTARQQ---PQRIPSGRIDSTRKFIEMEAHNNNGGTSS 4154

  Fly   703 DSSQCECNDCECG 715
            ...:...|....|
  Fly  4155 SPKRSTINYSSSG 4167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyb	NP_001097287.1	EF-hand_2	7..131	CDD:286194	29/111 (26%)
		EF-hand_3	135..223	CDD:286195	17/94 (18%)
		ZZ_dystrophin	232..280	CDD:239074	9/47 (19%)
		Ribosomal_L29	436..482	CDD:279204	14/84 (17%)
kst	NP_001097492.2	CH	76..178	CDD:237981
		CH	197..303	CDD:237981
		SPEC	450..640	CDD:238103
		SPEC	658..832	CDD:238103
		SH3	885..935	CDD:214620
		SPEC	1030..1236	CDD:238103
		SPEC	1134..1341	CDD:238103
		SPEC	1343..1551	CDD:238103
		SPEC	1449..1658	CDD:238103
		SPEC	1555..1764	CDD:238103
		SPEC	1765..1975	CDD:238103
		SPEC	1873..2080	CDD:238103
		SPEC	1979..2185	CDD:238103
		SPEC	2188..2402	CDD:238103
		SPEC	2407..2618	CDD:238103
		SPEC	2514..2725	CDD:238103
		SPEC	2726..2934	CDD:238103
		SPEC	2935..3145	CDD:238103
		SPEC	3042..3251	CDD:238103
		SPEC	3149..3357	CDD:238103
		SPEC	3359..3567	CDD:238103	36/154 (23%)
		SPEC	3465..3680	CDD:238103	53/265 (20%)
		PH	3799..3902	CDD:278594	18/102 (18%)
		PH_beta_spectrin	3801..3904	CDD:269975	17/102 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439897
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930