DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyb and Dtna

DIOPT Version :9

Sequence 1:	NP_001097287.1	Gene:	Dyb / 36362	FlyBaseID:	FBgn0033739	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_038953145.1	Gene:	Dtna / 307548	RGDID:	1561985	Length:	790	Species:	Rattus norvegicus

Alignment Length:	800	Identity:	312/800 - (39%)
Similarity:	428/800 - (53%)	Gaps:	158/800 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RVAILQDLRLQTFDSIRFASYRTASKLRYIQKSTNLHLVDIWNVIEAFRENGLNTLEPQSEVSVA 70
            |..:..::|.|..|.||.::||||.|||::||..|||||||||||||.|||.||.|:|..|::||
  Rat    15 RRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNIELNVA 79

  Fly    71 RLETLVSSLYHNLNKRLPTAQQVPVDSKAGLLLNWLLAAYTSDNSGKIRVFSIKVALATMCSGKL 135
            |||.::|::::.||||:|:..|:.|:....||||:||||:..:..|||.||::|:||||:|.||:
  Rat    80 RLEAVLSTMFYQLNKRMPSTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKI 144

  Fly   136 VDKLRYIFSQISDGAGQLVAWKLGEFLREVLALPAAVYESPTFHYKEGLEEEIFPAENKVTVNDF 200
            :||||||||.|||.:|.:|..:..:||||||.||.||:|.|:|.|.|......|..:.|||:|.|
  Rat   145 MDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGF 209

  Fly   201 MATLMSEPGPSCLVWLPLVHRLATVETIVHPTVCSVCHKENFTGFRYRCQRCHAYQLCQECFWHG 265
            :.||||:|.|.|||||||:||||.||.:.||..||.||.|:..|||||||:||.|||||:|||.|
  Rat   210 LDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRG 274

  Fly   266 KTSLNHQNDHEVKEYSSYKSPSKQIGHSLRKSFRCVPEKTVQVLPRFPDQPEKTLNLSHIV---P 327
            ....:|.|.|::|||:|:|||:|::.::|.||..|...:. .:.|.|||||||.|||:|||   |
  Rat   275 HAGGSHSNQHQMKEYTSWKSPAKKLTNALSKSLSCASSRE-PLHPMFPDQPEKPLNLAHIVDTWP 338

  Fly   328 PSPLPSHNGFSDPSGLVHGHHGPHPGLP-------------GQHGLFDRSST--LDSRATGRSLD 377
            |.|:.|.|      ..:..|..|..|.|             .|:.:..|::.  |..:....||:
  Rat   339 PRPVTSMN------DTLFSHSVPSSGSPFITRSSPPKDSEVEQNKILARAAPAFLKGKGIHYSLN 397

  Fly   378 SASGTAG--------TTMSR------VAAASANDEEHRLIARYAARLAQENRAPSNLPDNATP-- 426
            .|...|.        ..|.|      :.:::..|||||||||||||||.|:.:.......:.|
  Rat   398 VADRLADEHVLIGLYVNMLRNNPSCMLESSNRLDEEHRLIARYAARLAAESSSSQPTQQRSAPDV 462

  Fly   427 -IGTDNSRAQRELIAQLESKNKEIMREIARLRRQQE-----TEQMAPENPALINELRALRQRKGE 485
             ...|.::.||:|||:||:||:||::||.|||.:.|     |.:.|.:||.|:.|||.|||||.|
  Rat   463 SFTIDANKQQRQLIAELENKNREILQEIQRLRVEHEQASQPTPEKAQQNPTLLAELRLLRQRKDE 527

  Fly   486 LEGHLGALQDSRRQLMEQLEGLMRMLKNQQ-------TASPRSTPNSSPRSGKSPPMPGGAGILG 543
            ||..:.|||:|||:||.||||||::||.::       ..||||:|  |....:..|||    |..
  Rat   528 LEQRMSALQESRRELMVQLEGLMKLLKEEELKQGTQGAGSPRSSP--SHTISRPIPMP----IRS 586

  Fly   544 TSPMSALHAQQMQQHPMAGGVRASQQQLLQQQQQQAHGHGPFSQSQLEQLNQISSDMRSAFAANG 608
            ||..|.                                  |....| :.|..:..|::.|||
  Rat   587 TSACST----------------------------------PAYTPQ-DSLTGVGGDVQEAFA--- 613

  Fly   609 SATPPPMRTTTATANVSAIPSLNPISNQNPNLNPDAELNEAADHLTSAISHMVSDLNA------- 666
                                       |:...|...:|..|||.:|:.:|.:|.:||:
  Rat   614 ---------------------------QSSRRNLRNDLLVAADSITNTMSSLVKELNSEVASETE 651

  Fly   667 -------GRGRAQQLGPQPASSIPQARFIMPLEFR---HIEGGES---------EDSSQCECNDC 712
                   .|.:.:.|.|.|.|   :..|:..:..|   :|.||.:         ||.....  ..
  Rat   652 STVDSEFSRTQFEDLVPSPTS---EKSFLAQIHARKPGYIHGGATSTMHGDMVPEDGDPYP--QP 711

  Fly   713 ECGEY--EEVFRTDEDLECE 730
            |.|.|  |.|.:.:.:|:.|
  Rat   712 EDGNYENESVRQLENELQME 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyb	NP_001097287.1	EF-hand_2	7..131	CDD:286194	66/123 (54%)
		EF-hand_3	135..223	CDD:286195	49/87 (56%)
		ZZ_dystrophin	232..280	CDD:239074	27/47 (57%)
		Ribosomal_L29	436..482	CDD:279204	26/50 (52%)
Dtna	XP_038953145.1	EFh_DTNA	54..214	CDD:320007	85/159 (53%)
		EF-hand-like motif	54..94	CDD:320007	23/39 (59%)
		EF-hand-like motif	104..138	CDD:320007	17/33 (52%)
		EF-hand-like motif	144..180	CDD:320007	21/35 (60%)
		EF-hand-like motif	191..214	CDD:320007	8/22 (36%)
		ZZ_dystrophin	241..289	CDD:239074	27/47 (57%)
		SbcC	<425..>560	CDD:223496	67/134 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354118
Domainoid	1	1.000	193	1.000	Domainoid score	I3096
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1237
OMA	1	1.010	-	-		QHG49468
OrthoDB	1	1.010	-	-		D308769at33208
OrthoFinder	1	1.000	-	-		FOG0002910
OrthoInspector	1	1.000	-	-		otm45118
orthoMCL	1	0.900	-	-		OOG6_105554
Panther	1	1.100	-	-	LDO	PTHR12268
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2279
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910