DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyb and TUSC1

DIOPT Version :9

Sequence 1:	NP_001097287.1	Gene:	Dyb / 36362	FlyBaseID:	FBgn0033739	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	NP_001004125.2	Gene:	TUSC1 / 286319	HGNCID:	31010	Length:	209	Species:	Homo sapiens

Alignment Length:	218	Identity:	57/218 - (26%)
Similarity:	74/218 - (33%)	Gaps:	66/218 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 SGLVHGHHGPHPGLPGQHGLFDRSSTLDSRATGRSLDSASGTAGTTMSRVAAASANDEEHRLIAR 405
            ||...|...|..| .|..|...|:.....:...|..|.|:       |.:.|..|.||..    |
Human    29 SGRARGGGSPSGG-GGGVGWRGRADGARQQLEERFADLAA-------SHLEAIRARDEWD----R 81

  Fly   406 YAARLAQENRAPSNLPDNATPIGTDNSRAQRELIAQLESKNKEIMREIARL------------RR 458
            ..|||.|||          ..:..:|.|.:||        |:.:.|:..||            ||
Human    82 QNARLRQEN----------ARLRLENRRLKRE--------NRSLFRQALRLPGEGGNGTPAEARR 128

  Fly   459 QQE---TEQMA--------PENPALINELRALRQRKGELEGHLGALQDSRRQLME-QLEGLMRML 511
            ..|   |.:.|        |.:|      ||||.|..:||...      ||.|:: .||......
Human   129 VPEEASTNRRARDSGREDEPGSP------RALRARLEKLEAMY------RRALLQLHLEQRGPRP 181

  Fly   512 KNQQTASPRSTPNSSPRSGKSPP 534
            ...:...|...|:|..||..|.|
Human   182 SGDKEEQPLQEPDSGLRSRDSEP 204

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyb	NP_001097287.1	EF-hand_2	7..131	CDD:286194
		EF-hand_3	135..223	CDD:286195
		ZZ_dystrophin	232..280	CDD:239074
		Ribosomal_L29	436..482	CDD:279204	17/68 (25%)
TUSC1	NP_001004125.2	MreC	61..>115	CDD:418554	22/82 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960