DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyb and Dtna

DIOPT Version :9

Sequence 1:	NP_001097287.1	Gene:	Dyb / 36362	FlyBaseID:	FBgn0033739	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_036016865.1	Gene:	Dtna / 13527	MGIID:	106039	Length:	790	Species:	Mus musculus

Alignment Length:	796	Identity:	311/796 - (39%)
Similarity:	428/796 - (53%)	Gaps:	150/796 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RVAILQDLRLQTFDSIRFASYRTASKLRYIQKSTNLHLVDIWNVIEAFRENGLNTLEPQSEVSVA 70
            |..:..::|.|..|.||.::||||.|||::||..|||||||||||||.|||.||.|:|..|::||
Mouse    15 RRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNIELNVA 79

  Fly    71 RLETLVSSLYHNLNKRLPTAQQVPVDSKAGLLLNWLLAAYTSDNSGKIRVFSIKVALATMCSGKL 135
            |||.::|::::.||||:||..|:.|:....||||:||||:..:..|||.||::|:||||:|.||:
Mouse    80 RLEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKI 144

  Fly   136 VDKLRYIFSQISDGAGQLVAWKLGEFLREVLALPAAVYESPTFHYKEGLEEEIFPAENKVTVNDF 200
            :||||||||.|||.:|.:|..:..:||||||.||.||:|.|:|.|.|......|..:.|||:|.|
Mouse   145 MDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGF 209

  Fly   201 MATLMSEPGPSCLVWLPLVHRLATVETIVHPTVCSVCHKENFTGFRYRCQRCHAYQLCQECFWHG 265
            :.||||:|.|.|||||||:||||.||.:.||..||.||.|:..|||||||:||.|||||:|||.|
Mouse   210 LDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRG 274

  Fly   266 KTSLNHQNDHEVKEYSSYKSPSKQIGHSLRKSFRCVPEKTVQVLPRFPDQPEKTLNLSHIV---P 327
            ....:|.|.|::|||:|:|||:|::.::|.||..|...:. .:.|.|||||||.|||:|||   |
Mouse   275 HAGGSHSNQHQMKEYTSWKSPAKKLTNALSKSLSCASSRE-PLHPMFPDQPEKPLNLAHIVDTWP 338

  Fly   328 PSPLPSHNGFSDPSGLVHGHHGPHPGLP-------------GQHGLFDRSST--LDSRATGRSLD 377
            |.|:.|.|      ..:..|..|..|.|             .|:.:..|::.  |..|....||:
Mouse   339 PRPVTSMN------DTLFSHSVPSSGSPFITRSSPPKDSEVEQNKMLARAAPAFLKGRGIQYSLN 397

  Fly   378 SASGTAG--------TTMSR------VAAASANDEEHRLIARYAARLAQENRAPSNLPDNATP-- 426
            .|...|.        ..|.|      :.:::..|||||||||||||||.|:.:.......:.|
Mouse   398 VADRLADEHVLIGLYVNMLRNNPPCMLESSNRLDEEHRLIARYAARLAAESSSSQPTQQRSAPDI 462

  Fly   427 -IGTDNSRAQRELIAQLESKNKEIMREIARLRRQQE-----TEQMAPENPALINELRALRQRKGE 485
             ...|.::.||:|||:||:||:||::||.|||.:.|     |.:.|.:||.|:.|||.|||||.|
Mouse   463 SFTIDANKQQRQLIAELENKNREILQEIQRLRVEHEQASQPTPEKAQQNPTLLAELRLLRQRKDE 527

  Fly   486 LEGHLGALQDSRRQLMEQLEGLMRMLKNQ---QTASPRSTPNSSPRSGKSPPMPGGAGILGTSPM 547
            ||..:.|||:|||:||.||||||::||.:   |.....|:|.|||....|.|:|        .|:
Mouse   528 LEQRMSALQESRRELMVQLEGLMKLLKEEELKQGTQGASSPRSSPSHTISRPIP--------MPI 584

  Fly   548 SALHAQQMQQHPMAGGVRASQQQLLQQQQQQAHGHGPFSQSQLEQLNQISSDMRSAFAANGSATP 612
            .:..|.....|                             :..:.|..:..|::.|||
Mouse   585 RSASACPTPTH-----------------------------TPQDSLTGVGGDVQEAFA------- 613

  Fly   613 PPMRTTTATANVSAIPSLNPISNQNPNLNPDAELNEAADHLTSAISHMVSDLNA----------- 666
                                   |:...|..::|..|||.:|:.:|.:|.:||:
Mouse   614 -----------------------QSSRRNLRSDLLVAADSITNTMSSLVKELNSEVASETESTVD 655

  Fly   667 ---GRGRAQQLGPQPASSIPQARFIMPLEFR---HIEGGES---------EDSSQCECNDCECGE 716
               .|.:.:.|.|.|.|   :..|:..:..|   :|.||.:         ||..  .....|.|.
Mouse   656 SEFSRPQFEDLAPSPTS---EKAFLAQIHSRKPGYIHGGAASTTHGDMVPEDGD--PYTQPEDGN 715

  Fly   717 Y--EEVFRTDEDLECE 730
            |  |.|.:.:.:|:.|
Mouse   716 YENESVRQLENELQLE 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyb	NP_001097287.1	EF-hand_2	7..131	CDD:286194	67/123 (54%)
		EF-hand_3	135..223	CDD:286195	49/87 (56%)
		ZZ_dystrophin	232..280	CDD:239074	27/47 (57%)
		Ribosomal_L29	436..482	CDD:279204	26/50 (52%)
Dtna	XP_036016865.1	EFh_DTNA	54..214	CDD:320007	86/159 (54%)
		EF-hand-like motif	54..94	CDD:320007	23/39 (59%)
		EF-hand-like motif	104..138	CDD:320007	17/33 (52%)
		EF-hand-like motif	144..180	CDD:320007	21/35 (60%)
		EF-hand-like motif	191..214	CDD:320007	8/22 (36%)
		ZZ_dystrophin	241..289	CDD:239074	27/47 (57%)
		SbcC	<425..>560	CDD:223496	67/134 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850419
Domainoid	1	1.000	190	1.000	Domainoid score	I3265
eggNOG	1	0.900	-	-		E1_KOG4301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1282
Isobase	1	0.950	-	0	Normalized mean entropy	S3868
OMA	1	1.010	-	-		QHG49468
OrthoDB	1	1.010	-	-		D308769at33208
OrthoFinder	1	1.000	-	-		FOG0002910
OrthoInspector	1	1.000	-	-		otm43055
orthoMCL	1	0.900	-	-		OOG6_105554
Panther	1	1.100	-	-	LDO	PTHR12268
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2279
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.760