DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyb and dtnb

DIOPT Version :9

Sequence 1:	NP_001097287.1	Gene:	Dyb / 36362	FlyBaseID:	FBgn0033739	Length:	816	Species:	Drosophila melanogaster
Sequence 2:	XP_031757764.1	Gene:	dtnb / 100496192	XenbaseID:	XB-GENE-979789	Length:	636	Species:	Xenopus tropicalis

Alignment Length:	679	Identity:	290/679 - (42%)
Similarity:	390/679 - (57%)	Gaps:	110/679 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILQDLRLQTFDSIRFASYRTASKLRYIQKSTNLHLVDIWNVIEAFRENGLNTLEPQSEVSVARLE 73
            :..::|.|.||.||.::||||.|||::||..|||||||||:|||||:||||||:..:|::|:|||
Frog    18 LFMEMRAQNFDVIRLSTYRTACKLRFVQKRCNLHLVDIWNMIEAFRDNGLNTLDHNTEINVSRLE 82

  Fly    74 TLVSSLYHNLNKRLPTAQQVPVDSKAGLLLNWLLAAYTSDNSGKIRVFSIKVALATMCSGKLVDK 138
            |::||:|:.||||||:..|:.||....||||:::|||.|:..||:.|||:|..|||||.||::||
Frog    83 TIISSIYYQLNKRLPSTHQIGVDQSISLLLNFMIAAYDSEGHGKLTVFSVKAILATMCGGKILDK 147

  Fly   139 LRYIFSQISDGAGQLVAWKLGEFLREVLALPAAVYESPTFHYKEGLEEEIFPAENKVTVNDFMAT 203
            |||||||:||..|.:|..|..:||||||.||..|:|.|:|.|.|......||.:.|:.:|.|:.|
Frog   148 LRYIFSQVSDSTGLMVYTKFDQFLREVLKLPTTVFEGPSFGYTEHSARTCFPPQKKIALNMFLDT 212

  Fly   204 LMSEPGPSCLVWLPLVHRLATVETIVHPTVCSVCHKENFTGFRYRCQRCHAYQLCQECFWHGKTS 268
            :|::|.|.|||||||:||||.||.:.||..||.|..|:..|||||||:||.|||||.|||.|..:
Frog   213 IMADPPPQCLVWLPLMHRLAHVENVFHPVECSFCRSESMMGFRYRCQQCHNYQLCQNCFWRGHAN 277

  Fly   269 LNHQNDHEVKEYSSYKSPSKQIGHSLRKSFRCVPEKTVQVLPRFPDQPEKTLNLSHIVPPSPLPS 333
            ..|.|.|::||:||:|||:|::.|::.||..|||.:.:. .|.||:.|||.|:|:||||..||.:
Frog   278 GPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPSRELP-HPVFPEHPEKPLDLAHIVPARPLTN 341

  Fly   334 HN---------GFSDPSGLVHGHHGPHPGLPGQHGLFDRSSTLDSRATGRSLDSASGTAGTTMSR 389
            .|         |...|:..:|........:|.:|.|. .......|...|.|||.|..
Frog   342 MNDALVTHISSGAPTPTKRLHNSADTASRVPDEHALI-AEYVARLRFGTRVLDSPSRL------- 398

  Fly   390 VAAASANDEEHRLIARYAARLAQE----NRAPSNLPDNATPIGTDNSRAQRELIAQLESKNKEIM 450
                   |||||||||||||||.|    .|.|:.|..|     .|.::.||:|||:||:||:||:
Frog   399 -------DEEHRLIARYAARLAAEAGNSPRPPTELSFN-----FDANKQQRQLIAELENKNREIL 451

  Fly   451 REIARLRRQQE-----TEQMAPENPALINELRALRQRKGELEGHLGALQDSRRQLMEQLEGLMRM 510
            :||.|||.:.|     |.:.|.:||.|:.|||.|||||.|||..:.|||:|||:||.||||||::
Frog   452 QEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKL 516

  Fly   511 LK---NQQTASPRSTPNSSPRSGKSPPMPGGAGILGTSPMSALHAQQMQQHPMAGGVRASQQQLL 572
            ||   ::|.|....:|:.||..|.:.|||        .|:.:..|.....|
Frog   517 LKEEEHKQAAQATGSPHCSPSHGSNRPMP--------MPVRSTSAGSTPTH-------------- 559

  Fly   573 QQQQQQAHGHGPFSQSQLEQLNQISSDMRSAFAANGSATPPPMRTTTATANVSAIPSLNPISNQN 637
             ..|....|.|               :::.|||                              |.
Frog   560 -VPQDSFAGLG---------------EVQDAFA------------------------------QG 578

  Fly   638 PNLNPDAELNEAADHLTSAISHMVSDLNA 666
            ...|...:|..|||.:|:.:|.:|.:|::
Frog   579 TRRNLRNDLLVAADSITNTMSSLVKELHS 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyb	NP_001097287.1	EF-hand_2	7..131	CDD:286194	70/121 (58%)
		EF-hand_3	135..223	CDD:286195	46/87 (53%)
		ZZ_dystrophin	232..280	CDD:239074	26/47 (55%)
		Ribosomal_L29	436..482	CDD:279204	26/50 (52%)
dtnb	XP_031757764.1	EFh_DTN	54..214	CDD:320002	88/159 (55%)
		ZZ_dystrophin	241..289	CDD:239074	26/47 (55%)
		Golgin_A5	<399..594	CDD:401659	94/267 (35%)
		PRK12704	431..>525	CDD:237177	50/93 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I4006
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1264
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D308769at33208
OrthoFinder	1	1.000	-	-		FOG0002910
OrthoInspector	1	1.000	-	-		otm48182
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2279
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060