DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DUBAI and USP38

DIOPT Version :9

Sequence 1:	NP_610784.1	Gene:	DUBAI / 36361	FlyBaseID:	FBgn0033738	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_115946.2	Gene:	USP38 / 84640	HGNCID:	20067	Length:	1042	Species:	Homo sapiens

Alignment Length:	1034	Identity:	268/1034 - (25%)
Similarity:	405/1034 - (39%)	Gaps:	336/1034 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 KRDIKALLAYLQS-----IDMPE--------QGHNVMAICERVIVDL-ARLQ---------IPRG 107
            ::|: |:|.|:.:     :..|.        |...:..:|||....| |||.         ||:|
Human    98 RKDV-AILDYIHNGLKLIMSCPSVLDLFSLLQVEVLRMVCERPEPQLCARLSDLLTDFVQCIPKG 161

  Fly   108 ASCPRLKEDVCQ-----VGAFLATRNEKFHQMFY-------------------------LRVVYE 142
                :|....||     :|.|.....::.....|                         |:.|:.
Human   162 ----KLSITFCQQLVRTIGHFQCVSTQERELREYVSQVTKVSNLLQNIWKAEPATLLPSLQEVFA 222

  Fly   143 LITKSPFEPPPSCAVAIVFQLFDSTQILEAVHSL-LEQNVQDSSIKKTVNLLCDWITYCTFCSTL 206
            .|:.:.....||.|:|.:.|......|...:.|| .:.||:|:|:.:.:..:.||::: .....:
Human   223 SISSTDASFEPSVALASLVQHIPLQMITVLIRSLTTDPNVKDASMTQALCRMIDWLSW-PLAQHV 286

  Fly   207 NLWVLALLKGLRDQGKMALLDEIAMDNIEKLFHVMIFPALRQKAAPVVFHMLSTINQTPEVFHKI 271
            :.||:||||||....|..:|.::.:..||.:|:.:.||.:|..|..|:.|||.:...:||.||.|
Human   287 DTWVIALLKGLAAVQKFTILIDVTLLKIELVFNRLWFPLVRPGALAVLSHMLLSFQHSPEAFHLI 351

  Fly   272 LPRIPRVLQYVKNQSTTMDEIGLETKKC-LQQLVDLTSALMLRFYDQDELYVATKKALQTYEPSP 335
            :|.:..::...||.       ||.:... |.||.:|...:|..:....:||....:|::.: |.|
Human   352 VPHVVNLVHSFKND-------GLPSSTAFLVQLTELIHCMMYHYSGFPDLYEPILEAIKDF-PKP 408

  Fly   336 NCVALAKAMHENAQPWGRRN----------------ARVGLVNLGNTCYMNSVLQALAMTSDFSR 384
            :...:...::::|  |..::                .:.||:|||||||||||:|||.|.:||.|
Human   409 SEEKIKLILNQSA--WTSQSNSLASCLSRLSGKSETGKTGLINLGNTCYMNSVIQALFMATDFRR 471

  Fly   385 QILLIE---CNSVLLMKVQQQIALMHHSLRYELTPSRVLNATRPPSFTPGLQQDSSEFLGYLLDL 446
            |:|.:.   ||| |:.|:|...|.:.|:.|....|.....|:|||.|||..|||.||:|.:|||.
Human   472 QVLSLNLNGCNS-LMKKLQHLFAFLAHTQREAYAPRIFFEASRPPWFTPRSQQDCSEYLRFLLDR 535

  Fly   447 LHEHE----INSSSVTGHSVGPPKTG-REVDDVPALLSEDILSSGVIPYNSKDHELSSGSNSDNC 506
            |||.|    :.:|......:...:|. :||....|:|:|
Human   536 LHEEEKILKVQASHKPSEILECSETSLQEVASKAAVLTE-------------------------- 574

  Fly   507 NHKPTPTPPATPTKATNGLKQQGQQVDQAKPPSTIDKTFAGKLSTTYRCLNCGWESRNEDSFREL 571
                      || :.::|.|            :.|:|.|.|||.|..|||||...|:..::|.:|
Human   575 ----------TP-RTSDGEK------------TLIEKMFGGKLRTHIRCLNCRSTSQKVEAFTDL 616

  Fly   572 QLSF------------------------------PDDKED------------------------- 581
            .|:|                              |...|:
Human   617 SLAFCPSSSLENMSVQDPASSPSIQDGGLMQASVPGPSEEPVVYNPTTAAFICDSLVNEKTIGSP 681

  Fly   582 -----C------------------------GATNYSVQDLIEYYCSPEKLDGDNQYFCPQCKKLC 617
                 |                        |.|..||.||:.|:.:||.|.|||||:|..|..|.
Human   682 PNEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVTDLLNYFLAPEILTGDNQYYCENCASLQ 746

  Fly   618 DAERHIGVTQAPKNLILTLKQFKYDQKYHFRTKLMHKV--------------------------- 655
            :||:.:.:|:.|:.|||||.:|.||||||.|.|::..|
Human   747 NAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKILDNVSLPLVLELPVKRITSFSSLSESWSVDV 811

  Fly   656 -FHDESVT----VKMSAKDSLQEMSTVHYDLYAGVVHAGYSMDSGHYFTFA-------------- 701
             |.|.|..    :|.|..|.......|.|.|.:.|||:|.|.:||||:::|
Human   812 DFTDLSENLAKKLKPSGTDEASCTKLVPYLLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYH 876

  Fly   702 ------------------------------ADQAKNWYKFNDNVVTHSKPEEMHNLTS---PNTP 733
                                          .:.:|.|:.|||:.||.:..:.:..:||   .:|.
Human   877 QSEALALASSQSHLLGRDSPSAVFEQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKDTA 941

  Fly   734 YILFYKMCGHSNESNSVTASCSSSMVSGSNDQVVSVPLSPPLKLEELPRRLRDYVRKDNHVYNEE 798
            |:|.||. .||....|.....|...::|          .|||:.|     |.|.:.|||.:|.:|
Human   942 YVLLYKK-QHSTNGLSGNNPTSGLWING----------DPPLQKE-----LMDAITKDNKLYLQE 990

  Fly   799 LKMQRFKRGNSGHGNAFVSRHNFDGDGDEDDKAPPPPGGC----GGNGLGMN-INRFVF 852
            .::....|.......:...|.|...|.|       |||.|    ||.|.|.| :.|.||
Human   991 QELNARARALQAASASCSFRPNGFDDND-------PPGSCGPTGGGGGGGFNTVGRLVF 1042

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUBAI	NP_610784.1	UCH	358..738	CDD:278850	151/550 (27%)
DUBAI	NP_610784.1	Peptidase_C19H	359..739	CDD:239129	151/550 (27%)
USP38	NP_115946.2	Peptidase_C19H	446..947	CDD:239129	151/550 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2782
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2671
Isobase	1	0.950	-	0	Normalized mean entropy	S6513
OMA	1	1.010	-	-		QHG56146
OrthoDB	1	1.010	-	-		D431768at33208
OrthoFinder	1	1.000	-	-		FOG0004017
OrthoInspector	1	1.000	-	-		otm40791
orthoMCL	1	0.900	-	-		OOG6_105906
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5089
SonicParanoid	1	1.000	-	-		X3301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.820