DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DUBAI and USP1

DIOPT Version :9

Sequence 1:	NP_610784.1	Gene:	DUBAI / 36361	FlyBaseID:	FBgn0033738	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001017415.1	Gene:	USP1 / 7398	HGNCID:	12607	Length:	785	Species:	Homo sapiens

Alignment Length:	780	Identity:	153/780 - (19%)
Similarity:	254/780 - (32%)	Gaps:	312/780 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 LMLRFYDQDELYVATKKALQ------------------------TYEPSP-NCVALAKAMHENAQ 349
            |.|:|:.:.|    ||:||.                        ..:.|| ||     ...||..
Human    23 LSLKFFQKKE----TKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINC-----EKRENLL 78

  Fly   350 PWGRRNARVGLVNLGNTCYMNSVLQALAMTSDFSRQI---------------------------- 386
            |:      |||.|||||||:||:||.|.....|...:
Human    79 PF------VGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKE 137

  Fly   387 -------LLIECNSVLLMKVQQQIALMHHSLRY--ELT--PSRVLNATRP--PSFTPGLQQDSSE 438
                   |:....|:::...|.|.:.:.:..:|  ||.  |.|:||..|.  |.:...||.|:.|
Human   138 DSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQE 202

  Fly   439 FLGYLL-------DLLHEHE-----------------------INSSSVTG--HSVG-----PPK 466
            .|..:|       .||.:.|                       |||..:..  ||..     |..
Human   203 VLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPKEEMNGINSIEMDSMRHSEDFKEKLPKG 267

  Fly   467 TGREVDD-------------------------------------------VPALLSED------- 481
            .|:...|                                           :|..:||:
Human   268 NGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQTRSKRKATSDTLESPPKIIPKYISENESPRPSQ 332

  Fly   482 ------------------ILSS----GVIPYN------SKDHELSSGSNSDNCNHKPTPTPPATP 518
                              |||.    |.|..|      ||::|.....:...|....|
Human   333 KKSRVKINWLKSATKQPSILSKFCSLGKITTNQGVKGQSKENECDPEEDLGKCESDNT------- 390

  Fly   519 TKATN--GLKQQGQ-----QVDQAKPPS---------TIDKTFAGKLSTTYRCLNCGWESRNEDS 567
               ||  ||:..|.     .|::.||.:         .::|.|.|:|....|||.|...:...:.
Human   391 ---TNGCGLESPGNTVTPVNVNEVKPINKGEEQIGFELVEKLFQGQLVLRTRCLECESLTERRED 452

  Fly   568 FRELQLSFPDDK----EDCGATN-------YSVQDLIEYYCSPEKLDGDNQYFCPQCKKLCDAER 621
            |:::.:...:|:    |:....:       .:::..|..:.|.|::.|:::|||..|....:|||
Human   453 FQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAER 517

  Fly   622 HIGVTQAPKNLILTLKQF-----KYDQKYHFRTKLMHKVFHDESVTVKMSAKDSLQEMSTV---- 677
            .:...:.|:.:.:.||.|     ::|......:|:        :..:....|.||:|.||.
Human   518 SLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKI--------NTPLLTPLKLSLEEWSTKPTND 574

  Fly   678 HYDLYAGVVHAGYSMDSGHYFTFAADQAKNWYKFN------DNVVTHSKPEEMHNLTSPNTPYIL 736
            .|.|:|.|:|:|.::.||||.........|..:.:      |.:....|||.:
Human   575 SYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDKGNFVVDQMCEIGKPEPL------------ 627

  Fly   737 FYKMCGHSNESNSVTASCSSSMVSGSNDQVVSVPL---SPPLKLEELPRRLRDYV--------RK 790
                    ||..      :..:|...||:.||:.:   :.|.|:  |.::..:.:        :.
Human   628 --------NEEE------ARGVVENYNDEEVSIRVGGNTQPSKV--LNKKNVEAIGLLGGQKSKA 676

  Fly   791 DNHVYN-----EELKMQRFKRGNSGHGNAFVSRHNFDGDGDEDDKAPPPPGGCGGNGLGMNINRF 850
            |..:||     :::....|....:...:.....|..|.:.:..|:.            |:||:.|
Human   677 DYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSDQT------------GINISGF 729

Fly 851 850
Human 730 729

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUBAI	NP_610784.1	UCH	358..738	CDD:278850	117/577 (20%)
DUBAI	NP_610784.1	Peptidase_C19H	359..739	CDD:239129	116/577 (20%)
USP1	NP_001017415.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..52		4/18 (22%)
		Peptidase_C19	82..>222	CDD:321984	36/139 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..336		6/77 (8%)
		Peptidase_C19O	<424..599	CDD:239136	44/182 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..723		4/41 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900