DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUBAI and USP35

DIOPT Version :9

Sequence 1:	NP_610784.1	Gene:	DUBAI / 36361	FlyBaseID:	FBgn0033738	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_065849.1	Gene:	USP35 / 57558	HGNCID:	20061	Length:	1018	Species:	Homo sapiens

Alignment Length:	1053	Identity:	268/1053 - (25%)
Similarity:	411/1053 - (39%)	Gaps:	344/1053 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GGAGNGIPPNAKPMSANGMANAEENVLPKGMDTGSPAGESLNS-----------NRSGK---RDI 69
            ||||   ||..:.::.   ......:||:|     ||.:.:.:           .|.|.   ..:
Human    91 GGAG---PPGPRALAC---VQLGLQLLPEG-----PAADEVFALLRREVLRTVCERPGPAACAQV 144

  Fly    70 KALLAYLQSIDMPEQGHNVMAICERVIVDLARLQIP----RGASCPRLKEDVCQVGAFLAT--RN 128
            ..|||..... :|:..|.:: .|::::..|.|.:.|    .||  ....|...||...||.  |.
Human   145 ARLLARHPRC-VPDGPHRLL-FCQQLVRCLGRFRCPAEGEEGA--VEFLEQAQQVSGLLAQLWRA 205

  Fly   129 EKFHQMFYLRVVYELITKSPFEPPPSCAVAIVFQLFDSTQILEAVHSLL--EQNVQDSSIKKTVN 191
            :....:..|:.::.:|:.:..|||.|...::|..|  ..::::.|...|  :.:|.||.:...::
Human   206 QPAAILPCLKELFAVISCAEEEPPSSALASVVQHL--PLELMDGVVRNLSNDDSVTDSQMLTAIS 268

  Fly   192 LLCDWITYCTFCSTLNLWVLALLKGLRDQGKMALLDEIAMDNIEKLFHVMIFPALRQKAAPVVFH 256
            .:.||::: .....::.|::||||||....|.::|.|:::..|||:|..:::|.:|..|..|:.:
Human   269 RMIDWVSW-PLGKNIDKWIIALLKGLAAVKKFSILIEVSLTKIEKVFSKLLYPIVRGAALSVLKY 332

  Fly   257 MLSTINQTPEVFHKILPRI-PRVLQYVKNQSTTMDEIGLETKKCLQQLVDLTSALMLRFYDQDEL 320
            ||.|...:.|.||.:||.| |.|...||..|.:       ...||:||.:|...::.||....:|
Human   333 MLLTFQHSHEAFHLLLPHIPPMVASLVKEDSNS-------GTSCLEQLAELVHCMVFRFPGFPDL 390

  Fly   321 YVATKKALQTYEPSPNCVALAKAMHENAQPWGRRNA----------------RVGLVNLGNTCYM 369
            |....:|::... .||...:.:.:.::|  |..:.:                ::||:|||||||:
Human   391 YEPVMEAIKDLH-VPNEDRIKQLLGQDA--WTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYV 452

  Fly   370 NSVLQALAMTSDFSRQIL-LIECNSVLLM-KVQQQIALMHHSLRYELTPSRVLNATRPPSFTPGL 432
            ||:||||.|.|||...:| |.|.||..|| |:|.....:.||.|..::|...|:|:..|.|:||.
Human   453 NSILQALFMASDFRHCVLRLTENNSQPLMTKLQWLFGFLEHSQRPAISPENFLSASWTPWFSPGT 517

  Fly   433 QQDSSEFLGYLLDLLHEHEINSSSVTGHSVGPPKTGREVDDVPALLSEDILSSGVIPYNSKDHEL 497
            |||.||:|.||||.|||.|              |||..:
Human   518 QQDCSEYLKYLLDRLHEEE--------------KTGTRI-------------------------- 542

  Fly   498 SSGSNSDNCNHKPTPTPPATPTKATNGLKQQGQQVDQAKPPST-IDKTFAGKLSTTYRCLNCGWE 561
                 ........:|:||..|                ..|.|| ::|.|.||:.|...||.|...
Human   543 -----CQKLKQSSSPSPPEEP----------------PAPSSTSVEKMFGGKIVTRICCLCCLNV 586

  Fly   562 SRNEDSFRELQLSFP-------------------------------------------------- 576
            |..|::|.:|.|:||
Human   587 SSREEAFTDLSLAFPPPERCRRRRLGSVMRPTEDITARELPPPTSAQGPGRVGPRRQRKHCITED 651

  Fly   577 -----------DDKE-------------------------------------------------- 580
                       |.||
Human   652 TPPTSLYIEGLDSKEAGGQSSQEERIEREEEGKEERTEKEEVGEEEESTRGEGEREKEEEVEEEE 716

  Fly   581 -----------------------------------DCGAT-NYSVQDLIEYYCSPEKLDGDNQYF 609
                                               .||:. :.||.||:.|:.|||||..:|:|:
Human   717 EKVEKETEKEAEQEKEEDSLGAGTHPDAAIPSGERTCGSEGSRSVLDLVNYFLSPEKLTAENRYY 781

  Fly   610 CPQCKKLCDAERHIGVTQAPKNLILTLKQFKYDQKYHFRTKLMHKVFHDESVTVKMSAKDSLQEM 674
            |..|..|.|||:.:.::|.|..|||||.:|.:|    .||....|:..|  |::.:..:..|...
Human   782 CESCASLQDAEKVVELSQGPCYLILTLLRFSFD----LRTMRRRKILDD--VSIPLLLRLPLAGG 840

  Fly   675 STVHYDLYAGVVHAGYSMDSGHYFTFAADQA----------------KNWYKFNDNVVTHSKPEE 723
            ....|||.:.|||:|.|.:||||:.:|.:.|                ..||.|||..|:.|..|.
Human   841 RGQAYDLCSVVVHSGVSSESGHYYCYAREGAARPAASLGTADRPEPENQWYLFNDTRVSFSSFES 905

  Fly   724 MHNLTS---PNTPYILFYKMCGHSNESNSVTASCSSSMVSGSNDQVVSVPLSPPLKLEELPRRLR 785
            :.|:||   .:|.|:|||:    ........|...||.|.           :.|    .|.:.|.
Human   906 VSNVTSFFPKDTAYVLFYR----QRPREGPEAELGSSRVR-----------TEP----TLHKDLM 951

  Fly   786 DYVRKDNHVYNEELKMQRFKRGNSGHGNAFVSR--------HNFDGDGDEDDKAPPPPGGC---G 839
            :.:.|||.:|.:|.:.:...|.      |::|.        ..||.|.|||:.:   ||||   |
Human   952 EAISKDNILYLQEQEKEARSRA------AYISALPTSPHWGRGFDEDKDEDEGS---PGGCNPAG 1007

  Fly   840 GNGLGMNINRFVF 852
            ||  |.:.:|.||
Human  1008 GN--GGDFHRLVF 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUBAI	NP_610784.1	UCH	358..738	CDD:278850	143/548 (26%)
DUBAI	NP_610784.1	Peptidase_C19H	359..739	CDD:239129	144/548 (26%)
USP35	NP_065849.1	UCH	441..923	CDD:278850	143/548 (26%)
		Peptidase_C19	442..924	CDD:271592	144/548 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	544..566		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..757		5/146 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	984..1011		13/31 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2782
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H35459
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2671
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56146
OrthoDB	1	1.010	-	-		D431768at33208
OrthoFinder	1	1.000	-	-		FOG0004017
OrthoInspector	1	1.000	-	-		otm40791
orthoMCL	1	0.900	-	-		OOG6_105906
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5089
SonicParanoid	1	1.000	-	-		X3301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870