DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DUBAI and usp38

DIOPT Version :9

Sequence 1:	NP_610784.1	Gene:	DUBAI / 36361	FlyBaseID:	FBgn0033738	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	XP_003197722.1	Gene:	usp38 / 563778	ZFINID:	ZDB-GENE-101007-2	Length:	1014	Species:	Danio rerio

Alignment Length:	956	Identity:	259/956 - (27%)
Similarity:	413/956 - (43%)	Gaps:	270/956 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ICER-----------VIVDLARLQIPRGAS----------------CP-----RLKEDVCQVGAF 123
            ||||           ::.|.::. |||..:                ||     .|:|.|.||...
Zfish   135 ICERPEPATCAKLATILTDFSQC-IPRDKAGVLFCQQLVRTFAYFHCPASEERELREYVTQVSRV 198

  Fly   124 LAT-----RNEKFHQMFYLRVVYELITKSPFEPPPSCAVAIVFQLFDSTQILEAVHSL-LEQNVQ 182
            .|.     :.|....:..|:.|:.:|:.:.....||.|:|.:.|......|...:.|| .:|||:
Zfish   199 SALLQVIWKAEPTTLLPSLQEVFSIISSTDPSFEPSIALASLVQHIPLQMITVLIKSLTTDQNVK 263

  Fly   183 DSSIKKTVNLLCDWITYCTFCSTLNLWVLALLKGLRDQGKMALLDEIAMDNIEKLFHVMIFPALR 247
            |:|:.:.:..:.||::: ...:.::.||:||||||....|..:|.::.:..||::|:.:.:|.:|
Zfish   264 DASMTQALCRMIDWLSW-PLANHVDTWVIALLKGLAAVQKFTILIDVTLLKIEQVFNRLWYPIVR 327

  Fly   248 QKAAPVVFHMLSTINQTPEVFHKILPRIPRVLQYVKNQSTTMDEIGL-ETKKCLQQLVDLTSALM 311
            |.|..|:.|||.:...:||.||.::|.|..:::.:||.       || .:|..|.|..:|...:|
Zfish   328 QGALVVLSHMLLSFQHSPEAFHLVVPHIVPLVKSLKND-------GLPNSKTFLLQFAELIHCMM 385

  Fly   312 LRFYDQDELYVATKKALQTYEPSPNCVALAKAMHENAQPWGRRN----------------ARVGL 360
            .::....:||.:..::::.. |.|:...:...::::|  |..::                .:.||
Zfish   386 YQYSGFPDLYDSILESIKEL-PKPSEEKIKFVLNQSA--WTSQSNSFASGLLKITGKSETGKTGL 447

  Fly   361 VNLGNTCYMNSVLQALAMTSDFSRQILLIECN--SVLLMKVQQQIALMHHSLRYELTPSRVLNAT 423
            |||||||||||:||.|.|.:||.|.::.::.|  :.|:.|:|...|.:.|:.|...:|...|:.:
Zfish   448 VNLGNTCYMNSILQILFMATDFRRHVMSLQLNGSNTLMKKLQLLFAFLAHTQRAAYSPRSFLDVS 512

  Fly   424 RPPSFTPGLQQDSSEFLGYLLDLLHEHEINSSSVTGHSVGPPKTGREVDDVPALLSEDILSSGVI 488
            ||..|:.|.|||.||:|.:|||.|||.|...|::...|..|.         ||..|.:.|.:.|.
Zfish   513 RPTWFSAGSQQDCSEYLRFLLDRLHEEEKALSALQTASPKPE---------PATTSPETLHNAVS 568

  Fly   489 PYNSKDHELSSGSNSDNCNHKPTPTPPATPTKATNGLKQQGQQVDQAKPPSTIDKTFAGKLSTTY 553
            |           ..||..:|   |.|.|.                |.:..:.:::.|.|:|||..
Zfish   569 P-----------PISDVPSH---PDPAAA----------------QGETGTLVERMFGGRLSTAI 603

  Fly   554 RCLNCGWESRNEDSFRELQLSF-PDDKEDCGATN------------------------------- 586
            |||.|...|..|:.|.:|.|:| |...:..|.||
Zfish   604 RCLQCHSLSEKEEPFTDLSLAFCPSMSQPRGPTNEHKSSSTLGPCQGAVNGGSEASEGPVKEGAA 668

  Fly   587 -----------YSVQDLIEYYCSPEKLDGDNQYFCPQCKKLCDAERHIGVTQAPKNLILTLKQFK 640
                       .||.||::|:.:||.|:.:|.|||.:|..|..||:.:.|..||:.|||||.:|.
Zfish   669 SGMERPMVEPTISVPDLVDYFLAPEILENENCYFCERCASLQRAEKAMRVVAAPEYLILTLLRFS 733

  Fly   641 YDQKYHFRTKLMHKV-----------FHDESVTVKMSAKDS------------------------ 670
            ||...|.|.|::..|           .|..|.:..::|..|
Zfish   734 YDATCHVRRKILDNVGIPLHMSLPLHQHSSSSSSNVAASSSTESPDSCENLAKKLKPSQKEEGIA 798

  Fly   671 ------------LQEMSTVHYDLYAGVVHAGYSMDSGHYFTF----------------------- 700
                        ||::| |.|.|.:.|:|:|.|.|||||:::
Zfish   799 ESRMKSKKNNSDLQKLS-VPYVLSSVVMHSGMSSDSGHYYSYGRNVSSDDGCVAHTSPKSLDNSS 862

  Fly   701 --------------AADQAKNWYKFNDNVVTHSKPEEMHNLTS---PNTPYILFYKMCGHSNESN 748
                          |..::.:|:.|||:.||.:..:.:.|:||   .:|.|:|.|:....|.|
Zfish   863 QSESSTAPQEETGRADPKSADWFLFNDSRVTFTNFQSLQNVTSRFPKDTAYVLIYRKQEVSGE-- 925

  Fly   749 SVTASCSSSMVSGSNDQVVSVPLS--PPLKLEELPRRLRDYVRKDNHVYNEELKMQRFKRGNSGH 811
               ||.|..:|:|:.       ||  |||:.|     |.|.:.|||.::.:|.::....|..
Zfish   926 ---ASNSGPVVNGAR-------LSGEPPLQKE-----LMDAITKDNKLFLQEQELNARTRAL--- 972

  Fly   812 GNAFVSRHNFDGDGDEDDKAPPPPGGC----GGNGLGMN-INRFVF 852
             .|..:..:|..:|.:|::   |||.|    ||.|.|.| |:|.||
Zfish   973 -QATSASCSFRPNGSDDNE---PPGSCGPSGGGGGGGFNTISRLVF 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUBAI	NP_610784.1	UCH	358..738	CDD:278850	144/511 (28%)
DUBAI	NP_610784.1	Peptidase_C19H	359..739	CDD:239129	144/511 (28%)
usp38	XP_003197722.1	UCH	445..917	CDD:278850	144/511 (28%)
usp38	XP_003197722.1	Peptidase_C19H	446..918	CDD:239129	144/511 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I3751
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3101
OMA	1	1.010	-	-		QHG56146
OrthoDB	1	1.010	-	-		D431768at33208
OrthoFinder	1	1.000	-	-		FOG0004017
OrthoInspector	1	1.000	-	-		oto41540
orthoMCL	1	0.900	-	-		OOG6_105906
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5089
SonicParanoid	1	1.000	-	-		X3301
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870