DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DUBAI and Usp16-45

DIOPT Version :9

Sequence 1:	NP_610784.1	Gene:	DUBAI / 36361	FlyBaseID:	FBgn0033738	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_001284890.1	Gene:	Usp16-45 / 31458	FlyBaseID:	FBgn0029763	Length:	1126	Species:	Drosophila melanogaster

Alignment Length:	956	Identity:	177/956 - (18%)
Similarity:	307/956 - (32%)	Gaps:	289/956 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ASDNAGGAGNG--------IPPNAKPMSANGMANAEENVLPKGM----DTGSPAGESLNSNRSGK 66
            |:...||.|:.        :||   |..::|::.::......||    |..|   .:.|.|...|
  Fly   229 AAGGGGGVGSSRNRQVAIPMPP---PEPSSGLSTSDSLTSVPGMAKRIDQYS---ATTNGNTGNK 287

  Fly    67 RDIKALLAYLQSIDMPE-QG---------HNVMAIC-------ERVIVDLA----RLQIPRGA-- 108
            |.:......:::..:|. :|         .|.:..|       ..|:.:|:    ...:|.|.
  Fly   288 RLLTLETPRIENERLPRVRGLTNLGNTCFFNAVMQCLAQTPFLLSVLKELSEPGEEFILPGGTFT 352

  Fly   109 -------SCPRLKEDVCQVG---AFLATRNEKFH---QMFYLRVVYELITKSPFEPPPSCAVAIV 160
                   ..|.:|..:...|   |.||...|:..   .:|..|.:::.:          |.....
  Fly   353 IKDKGDIELPMIKGTLSSWGGLTAALANALEELQAGGSVFTPRKLFDRL----------CVKCPQ 407

  Fly   161 FQLFDSTQILEAVHSLLEQNVQDSSIKKTVNLLCDWITYCTFCSTLNLWVLALLKGLRDQGKMAL 225
            |...|.....|.:..||| :|::..:|:...::..           ||       |.:||...::
  Fly   408 FTGGDQHDAHELLRQLLE-SVRNEDLKRYQRVILQ-----------NL-------GYKDQDVNSV 453

  Fly   226 LDEI----------AMDNI---EKLFHVMIFPALRQKAAPVVFHMLSTINQ------TPEVFHKI 271
            .:|:          |.|.|   |::|...:...|..:..    |.:|:.::      .|....|
  Fly   454 SEEMRQKCKIYGNQAGDRILRPEQVFRGFLVSTLTCQDC----HNVSSRHEYFLDMSLPVAVEK- 513

  Fly   272 LPRIPR------VLQYVKNQSTTMDEIGLETKKCLQQLVDLTSALMLRFYDQDELYVATKKA--L 328
             |:.|:      .|....:.|:.....|..|             :..:|.|....:.|:..:  |
  Fly   514 -PQPPQRRKPSPELSLTSSSSSVTPSTGQPT-------------INTKFTDGSVNFTASSPSFFL 564

  Fly   329 QTYE-----PSPNCVALAKAMHENAQPWGRRNARVGLVNLGNTCYMNSVLQALAMTSDFSRQIL- 387
            ..:|     ||.:.|...|.....|:...::..:..|...||.....:.|.......|.|...|
  Fly   565 HAHEAASLGPSKSQVKKEKERQRKAKRAAKKRQKSSLNLNGNDSGNGNELAESVDQDDASLASLG 629

  Fly   388 ---------LIECNSVLLMKVQQQIALMHHSLRYELTPSRVLNATRP-----PSFTPGLQQDSSE 438
                     |.:.|..........:....|| ..::..:.|.:...|     ||.|..|...|..
  Fly   630 AGDGQANDGLEQTNGQTEDSTTSSVTTSEHS-DADVEDNLVEDTAAPSTNNVPSSTASLTAPSKT 693

  Fly   439 FLGYLLDLLHEHEINSSSVTGHSVGPPKTGREVDDVPALLSEDILSSGVIPYNSKDHELSSGSNS 503
            ::.                :..:..||  |.:.||.|..:.:|.|         ::.|..||..:
  Fly   694 YMD----------------SNGNAQPP--GEKRDDTPEHMDKDSL---------EEDENDSGIAT 731

  Fly   504 DNCNHKPTPTPPATPTKAT--------NGLK-QQGQQVDQAKPPSTIDKTFAGKLSTTYRCLNCG 559
               :..||.|..:|.|.||        :||. ..|...|...|.|.:....:.|.::..|.::.|
  Fly   732 ---SPAPTATNSSTSTSATGNNNSVAGSGLSGSSGALEDPLAPASLVTAGLSEKGASVIRQVSVG 793

  Fly   560 WE----SRNEDSFRELQL---------------------------SFPD------DKEDCGATNY 587
            .|    :..||:..|.:.                           |:.|      .:..|.....
  Fly   794 AEQGASNGTEDADGEAKAIEQPEKTPSQAQAMAQAQARTKRVRTQSYSDWSTTIAPRYQCEDGEC 858

  Fly   588 SVQDLIEYYCSPEKLDGDNQYFCPQCKKL------------CDAERHIGVTQAPKNLILTLKQFK 640
            |||..:..:.:.|.:.|.|:..|..|.:.            .:|.:.:.|:..|..|||.||:|:
  Fly   859 SVQSCLNNFTAVELMTGQNKVGCDSCTQRINGSDPKAKSVNTNATKQLLVSSPPAVLILHLKRFQ 923

  Fly   641 YDQKYHFRTKLMHKVFHDESVTVKMSAKDSLQEMSTVH-------YDLYAGVVHAGYSMDSGHYF 698
            ...:..|| ||...|.:...:.:.......::.:..:.       |.||..|.|:| .|..|||.
  Fly   924 LGPRCIFR-KLTRPVSYPNLLDIAAFCGSKVKNLPNIDRKQKKLLYALYGVVEHSG-GMYGGHYT 986

  Fly   699 TFA-----------------------ADQAKNWYKFNDNVVTHSKPEEMHNLTSPNTPYILFYKM 740
            .:.                       .||..:..|..:.::...|..|.|            .|:
  Fly   987 AYVKVRPKVAPGDKRWKFLPHGSKAELDQDDDQLKKLEELLAKEKAREQH------------LKV 1039

  Fly   741 CGHSNE-----SNSVTASCSSSMVSGSNDQVVSVPLSP--PLKLEE 779
            ...|::     |||.|:..|.:..:...:|.......|  |.:|||
  Fly  1040 LDDSDDFSNSSSNSSTSDESQTPATPLEEQQTQQAQQPQQPQQLEE 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUBAI	NP_610784.1	UCH	358..738	CDD:278850	90/482 (19%)
DUBAI	NP_610784.1	Peptidase_C19H	359..739	CDD:239129	90/482 (19%)
Usp16-45	NP_001284890.1	zf-UBP	108..159	CDD:280334
		Peptidase_C19	307..>512	CDD:271592	40/237 (17%)
		Peptidase_C19K	<849..1123	CDD:239132	52/251 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24006
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030