DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DUBAI and Usp35

DIOPT Version :9

Sequence 1:	NP_610784.1	Gene:	DUBAI / 36361	FlyBaseID:	FBgn0033738	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	XP_238899.4	Gene:	Usp35 / 308834	RGDID:	1565984	Length:	1007	Species:	Rattus norvegicus

Alignment Length:	1047	Identity:	268/1047 - (25%)
Similarity:	414/1047 - (39%)	Gaps:	343/1047 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GGAGNGIPPNAKPMSANGMANAEENVLPKGMDTGSPAGESLNS-----------NRSGK---RDI 69
            ||||   ||.|:.::.   ......:||.|     ||.:.:.:           .|.|.   ..:
  Rat    91 GGAG---PPGARALAC---VQLGLQLLPDG-----PAADEVFALLRREVLRTVCERPGPAACAQV 144

  Fly    70 KALLAYLQSIDMPEQGHNVMAICERVIVDLARLQIP----RGASCPRLKEDVCQVGAFLAT--RN 128
            ..|||..... :|:..|.:: .|::::..|.|.:.|    .||  ....|...||...||.  |.
  Rat   145 ARLLARHPRC-VPDGAHRLL-FCQQLVRCLGRFRCPAEGEEGA--VEFLEQAQQVSGLLAQLWRA 205

  Fly   129 EKFHQMFYLRVVYELITKSPFEPPPSCAVAIVFQLFDSTQILEAVHSLL--EQNVQDSSIKKTVN 191
            :....:..|:.::.:|:.:..|||.|...::|..|  ..::::.|...|  :.:|.||.:...::
  Rat   206 QPAAILPCLKELFAVISCTEEEPPSSALASVVQHL--PLELMDGVVRNLSNDDSVTDSQMLTAIS 268

  Fly   192 LLCDWITYCTFCSTLNLWVLALLKGLRDQGKMALLDEIAMDNIEKLFHVMIFPALRQKAAPVVFH 256
            .:.||::: .....::.|::||||||....|.::|.|:::..|||:|..:::|.:|..|..|:.:
  Rat   269 RMIDWVSW-PLGKNIDKWIIALLKGLAAVKKFSILIEVSLAKIEKVFSKLLYPIVRGAALCVLKY 332

  Fly   257 MLSTINQTPEVFHKILPRI-PRVLQYVKNQSTTMDEIGLETKKCLQQLVDLTSALMLRFYDQDEL 320
            ||.|...:.|.||.:||.| |.|...||..|.:       ...||:||.:|...::.||....:|
  Rat   333 MLLTFQHSHEAFHLLLPHIPPMVAALVKEDSNS-------GTSCLEQLAELVHCMVFRFPGFPDL 390

  Fly   321 YVATKKALQTYEPSPNCVALAKAMHENAQPWGRRNA----------------RVGLVNLGNTCYM 369
            |....:|::... .||...:.:.:.::|  |..:.:                ::||:|||||||:
  Rat   391 YEPVMEAIKDLH-IPNEDRIKQLLGQDA--WTSQKSELAGFYPRLMAKSDTGKIGLINLGNTCYV 452

  Fly   370 NSVLQALAMTSDFSRQIL-LIECNSVLLM-KVQQQIALMHHSLRYELTPSRVLNATRPPSFTPGL 432
            |||||||.|.|||...:| |.|.||..|| |:|...|.:.||.|..::|...|:|:..|.|:||.
  Rat   453 NSVLQALFMASDFRHCVLRLTENNSQPLMTKLQWLFAFLEHSQRPAISPENFLSASWTPWFSPGT 517

  Fly   433 QQDSSEFLGYLLDLLHEHEINSSSVTGHSVGPPKTGREVDDVPALLSEDILSSGVIPYNSKDHEL 497
            |||.||:|.||||.|||.|              |||
  Rat   518 QQDCSEYLKYLLDRLHEEE--------------KTG----------------------------- 539

  Fly   498 SSGSNSDNCNHKPTPTPPATPTKATNGLKQQGQQVDQAKPPS----TIDKTFAGKLSTTYRCLNC 558
                                 |:....|||......|.:.||    ::::.|.||:.|...||:|
  Rat   540 ---------------------TRICQKLKQSSLPSPQEELPSSNATSVERMFGGKIVTRICCLHC 583

  Fly   559 GWESRNEDSFRELQLSFP----------------------------------------------- 576
            ...|..|::|.:|.|:||
  Rat   584 LNVSSREEAFTDLSLAFPPPERSRHRRLGSVMLPTEDVRAQELTLAPRAPGAQRQRKHCITGDAP 648

  Fly   577 ------------------------------------------------------------DDKED 581
                                                                        |:||.
  Rat   649 RTGLDIEGVDTVGNGGQSGQEKVEREQAGKEKEVAEDREEEGPREEEKEEGEEKDKEKKEDEKEK 713

  Fly   582 -----------------------------CGAT-NYSVQDLIEYYCSPEKLDGDNQYFCPQCKKL 616
                                         ||.. :.||.||:.|:.|||:|..:|:|:|..|..|
  Rat   714 EAEDGKEKEGDSLGPGTRKDAATPPREQACGPEGSRSVLDLVNYFLSPERLTAENRYYCESCASL 778

  Fly   617 CDAERHIGVTQAPKNLILTLKQFKYDQKYHFRTKLMHKVFHDESVTVKMSAKDSLQEMSTVHYDL 681
            .|||:.:.::|.|..|||||.:|.:|    .||....|:..|  ||:.:..:..|.......|||
  Rat   779 QDAEKVVELSQGPCYLILTLLRFSFD----LRTMRRRKILDD--VTIPLLLRLPLAGGQGQAYDL 837

  Fly   682 YAGVVHAGYSMDSGHYFTFAADQA----------------KNWYKFNDNVVTHSKPEEMHNLTS- 729
            .:.|||:|.|.:||||:.:|.:.|                ..||.|||..|:.|..|.:.|:||
  Rat   838 CSVVVHSGVSSESGHYYCYAREGAARPAPVLGSTERPEPENQWYLFNDTRVSFSSFESVSNVTSF 902

  Fly   730 --PNTPYILFYKMCGHSNESNSVTASCSSSMVSGSNDQVVSVPLSPPLKLE-ELPRRLRDYVRKD 791
              .:|.|:|||:                    ....:...:.|.||.::.| .|.:.|.:.:.||
  Rat   903 FPKDTAYVLFYR--------------------QRPQEAPEAEPGSPRVRAEPTLHKDLMEAISKD 947

  Fly   792 NHVYNEELKMQRFKRGNSGHGNAFVS--------RHNFDGDGDEDDKAPPPPGGC---GGNGLGM 845
            |.:|.:|.:.:...|.      |::|        ...||.|.|||:.:   .|||   ||||
  Rat   948 NVLYLQEQEKEARSRA------AYISTLPAPPHWSRGFDEDKDEDEGS---AGGCNPAGGNG--- 1000

  Fly   846 NINRFVF 852
            :.:|.||
  Rat  1001 DFHRLVF 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUBAI	NP_610784.1	UCH	358..738	CDD:278850	144/541 (27%)
DUBAI	NP_610784.1	Peptidase_C19H	359..739	CDD:239129	145/541 (27%)
Usp35	XP_238899.4	UCH	441..913	CDD:278850	144/541 (27%)
Usp35	XP_238899.4	Peptidase_C19	442..914	CDD:271592	145/541 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	208	1.000	Domainoid score	I2759
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H35459
Inparanoid	1	1.050	298	1.000	Inparanoid score	I2631
OMA	1	1.010	-	-		QHG56146
OrthoDB	1	1.010	-	-		D431768at33208
OrthoFinder	1	1.000	-	-		FOG0004017
OrthoInspector	1	1.000	-	-		otm44928
orthoMCL	1	0.900	-	-		OOG6_105906
Panther	1	1.100	-	-	O	PTHR24006
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3301
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840