DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DUBAI and duo-1

DIOPT Version :9

Sequence 1:	NP_610784.1	Gene:	DUBAI / 36361	FlyBaseID:	FBgn0033738	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_505931.3	Gene:	duo-1 / 179586	WormBaseID:	WBGene00001110	Length:	877	Species:	Caenorhabditis elegans

Alignment Length:	784	Identity:	144/784 - (18%)
Similarity:	234/784 - (29%)	Gaps:	356/784 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 PPSCA-----------VAIVFQLFDSTQILEAVHSLLEQNVQDSSIKKTVNLLCDWITYCTFCST 205
            |||.|           |..:|    :.|||...|....|..:.||                 .:|
Worm   116 PPSAASGSSSRTEKSSVRPIF----NEQILREDHEKARQLSRPSS-----------------QAT 159

  Fly   206 LNLWVLALLKGLRDQGK---MALLDEI-----AMDNIEKLFHVMIFPALRQKAAPVVFHMLSTIN 262
            .:..|.:.|..  |||:   :.|:|::     |.|:::|          .:|.:||  ..|.|
Worm   160 KSSEVASRLSS--DQGRESSIGLMDQMVASSDAFDSLKK----------DRKRSPV--DALQT-- 208

  Fly   263 QTPEVFHKILPRIPRVLQYVKNQSTTMDEIGLETKKCLQQLVDLTSALMLRFYDQDELYVATKKA 327
            ..|:...      |:..:.:|::....::...||.                   ..|:....:.:
Worm   209 SAPKTMK------PKRSEDIKDEKQRDEKPQAETV-------------------FSEILEPAQSS 248

  Fly   328 LQTYEPSPNCVALAKAMHENAQPWGRRNARVGLVNLGNTCYMNSVLQALAMTSDFSRQILLIECN 392
            .::..|..:.....:.:|||.|          |||.||:||.||.:||::     |...|:|.|.
Worm   249 KRSESPLLSSDVFLRKLHENRQ----------LVNTGNSCYYNSTMQAVS-----SCNPLVIRCE 298

  Fly   393 SVLLMKVQQQIALMHHSL----------------------------------------RYELTPS 417
            .:..| |:..|.|...|:                                        ||:|...
Worm   299 QLYRM-VRDNIELFDDSMNNDQADIKRKYIVLQNFLKVVICLGWHFNKRNEGKSIELRRYDLLQY 362

  Fly   418 RVLNATRPPSFTPGLQQDSSEFLGYLLDLLHEHEINSSSVTGHSVGPPKTGREVDDVPALLSEDI 482
            |.........|....|||:.|||..|:.                        .|||...::|:::
Worm   363 RQNVGKINEEFNNDDQQDAHEFLLTLIG------------------------AVDDAMGVMSKNV 403

  Fly   483 LSSGVIPYNSKDHELSSGSNSDNCNHKPTPTPPATPTKATNGLKQQGQQVDQAKPPSTIDKTFAG 547
                              ...||......|.                             :.|..
Worm   404 ------------------KTIDNVGITLNPA-----------------------------RAFKI 421

  Fly   548 KLSTTYRCLNCGWESRNEDSFRELQLSFPDDKEDCGATNYSVQDLIEYYCSPEKLDGDNQYFCPQ 612
            .:.|.|.|..|..|....||..:|.:|..|   .|     |||.|:..:.....::.:    |..
Worm   422 DVETMYVCQGCSNEELKVDSRNDLGVSVMD---GC-----SVQKLVSSFVKWSPIEKE----CSS 474

  Fly   613 CK-KLCDA-ERHIGVTQAPKNLILTLKQFKYD--------QKYHFRTKLMHK-----------VF 656
            || |:..: ||   ::..|:.||:.||:::.:        :|...|.:...|           |.
Worm   475 CKHKISSSCER---ISTFPECLIINLKRYELEGQGPPFSMKKKSCRVEPSFKLDVSSLGNFPPVE 536

  Fly   657 HDE-------SVTVKMSAKDS-LQEMSTVHYDLYAGVVHAGYSMDSGHYFTFAADQAKNWYKFND 713
            |.|       |.|..::::|| |.|::|                |..|              |||
Worm   537 HPEMFENKEYSTTEPVNSEDSRLAEITT----------------DDAH--------------FND 571

  Fly   714 NVVTHSKPEEMHNLTSPNTPYILFYKMCGHSNESNSVTASCSSSMVSGSNDQVVSVPLSPPLKLE 778
            :.|:.                    ::.|.::|..|   .||                   :.:|
Worm   572 SRVSG--------------------RLLGGADEEMS---QCS-------------------VIVE 594

  Fly   779 ELPRRLRDYV-----RKD----------------------NHVYNEELKMQRFK-----RGNSGH 811
            ::.:|...|.     .||                      .|:.....||.:|:     ||.:..
Worm   595 DVKKRKELYFNIFSNEKDFDDILDEMGINNGENQKRFHFERHITGPPSKMYQFQLPGATRGITPD 659

  Fly   812 GNAF 815
            ||.|
Worm   660 GNCF 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUBAI	NP_610784.1	UCH	358..738	CDD:278850	85/448 (19%)
DUBAI	NP_610784.1	Peptidase_C19H	359..739	CDD:239129	85/448 (19%)
duo-1	NP_505931.3	Peptidase_C19Q	270..875	CDD:239138	105/568 (18%)
		OTU	657..>743	CDD:303090	3/7 (43%)
		Peptidase_C19	<750..861	CDD:271592
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1864
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900