DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DUBAI and T24B8.7

DIOPT Version :9

Sequence 1:	NP_610784.1	Gene:	DUBAI / 36361	FlyBaseID:	FBgn0033738	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	NP_495931.4	Gene:	T24B8.7 / 174440	WormBaseID:	WBGene00011980	Length:	2938	Species:	Caenorhabditis elegans

Alignment Length:	920	Identity:	151/920 - (16%)
Similarity:	288/920 - (31%)	Gaps:	364/920 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EENVLPKGMDTGSPAGESLNSNRSGKRDIKALLAYLQSIDMPEQGHNVMAICERVIVDLARLQIP 105
            :||::..|.|:......||          |.||....|:.:    |      :....||..||..
Worm  1592 QENIVKIGKDSFEITCVSL----------KMLLEMFMSLPL----H------DGFTSDLNELQRR 1636

  Fly   106 RGASCPRLKEDVCQVGAFLATRNEKFHQMFYLRVVYELITKSPFEPPPSCAVAIVFQLFDSTQIL 170
            :...|..:.:.|.::              ||            ||.|..|...
Worm  1637 QRQHCDGIVQTVVEI--------------FY------------FESPRRCRED------------ 1663

  Fly   171 EAVHSLLEQNVQDSSI-KKTVNLLCDWITYC-----TFCSTLNLWVLALLKGLRDQGKMAL---- 225
                   ::::..|.: .|.:.::.|.|...     .||:|.|  .|||.:.:....||.:
Worm  1664 -------QKDIDWSQLGHKPIEIIRDQIKSLLGFKPRFCTTNN--DLALTENIYAAAKMRMISCL 1719

  Fly   226 --------LDEIAMDNIEKLFHVMIFPALRQKAAPVVFHMLSTINQTPEVFHKILPRIPRVLQYV 282
                    :::.:...|:.:.:..:||.|                  |::...:........:|.
Worm  1720 LPYCSQSDIEDCSKAFIDAIINDFLFPEL------------------PDIEDSMFEEESIRWEYQ 1766

  Fly   283 KNQST--TMDEIGLETKKCLQQLVDLTSALMLRFYDQDELYVATKKALQTYEPSPNCVALAKAMH 345
            ..::.  |::.....:.|...||:::.|..|:              |.:||:||...:..
Worm  1767 AREAAIQTLNAFCERSYKNSHQLLNMWSKFMI--------------AQKTYDPSYRPIIR----- 1812

  Fly   346 ENAQPWGRRNARVGLVNLGNTCYMNSVLQALAMTSDFSRQILLI----------ECNSVLLMKVQ 400
                  ||:..:||:.|.|.|||||:::|.|......||:::.:          :..:.||.::|
Worm  1813 ------GRQFDKVGMKNDGGTCYMNAMIQQLVHVPGLSRELIALQNIDPQLRWGDNTAALLCELQ 1871

  Fly   401 QQIALMHHSLRYELTPSRVLNATRPPSFTPGLQQDSSEFLGYLLDLLHEHEINSSSVTGHSVGPP 465
            :..|.::.:....:.|..:....|   |.|.:
Worm  1872 RVFAQLNFAQCQAIVPEGLWKEFR---FEPDM--------------------------------- 1900

  Fly   466 KTGREVDDVPALLSEDILSSGVIPYNSKDHELSSGSNS---DNCNHKPTPTPPATPTKATNGLKQ 527
                                   |.|:|.|..:....|   |.|:               |.||
Worm  1901 -----------------------PLNTKQHHDAIDFYSILLDKCD---------------NVLK- 1926

  Fly   528 QGQQVDQAKPPSTIDKTFAGKLSTTYRCLNCGWESRNEDSFRELQLSFPDDKEDC---GATNYSV 589
                  :.:.|......|.||.|....|..| |.          :...||::.:|   ..:..::
Worm  1927 ------KLELPPLFQNRFFGKYSYEKICYGC-WH----------RYKSPDEEFNCISLALSGDNL 1974

  Fly   590 QDLIEYYCSPEKLDGDNQYFCPQCKKLCDAERHIGVTQAPKNLILTLKQFKYD----------QK 644
            ::.:|.:.:...::|:|.|.|.:|.:...........:.|..:.:.||:|.||          |.
Worm  1975 EEALENFLAAHVMEGENAYHCEKCDEKKTTLNRTSFLELPSTMTIQLKRFTYDLVNNMIRKDNQL 2039

  Fly   645 YHF---------RTKLMH----------------------------------------------- 653
            :.|         .|...|
Worm  2040 FRFPFEIDMTPYMTTSRHVPDEHVQDLFDEMLYGNGEADEAPSPPHKNGVAEKPNLGSGSASTPS 2104

  Fly   654 ------KVF-HDESVTVKMSAK-------DSLQEMSTVHYDLYAGVVHAGYSMDSGHYFTFAADQ 704
                  |:| ...|.|:::|..       |:..:...:.|:|...:.|:|.: .:|||::|..::
Worm  2105 LESAQKKMFRRHRSSTMRLSQSFANTSGFDTPSQQKPLIYELVGVLAHSGIA-TAGHYYSFIKER 2168

  Fly   705 AK---------NWYKFNDNVVTHSKPEEMHNLTSPNT------------------PYILFYKMCG 742
            .:         .|:..||.:|:......:.:|....|                  .|:|||:
Worm  2169 REEFRDSPHYNKWHHINDMIVSPMSFNNIEDLWYGGTFTQEGVFIGLDERVRHWNAYVLFYE--- 2230

  Fly   743 HSNESNSVTASCSSSMVSGSNDQVVSVPLSPPLKL----EELPRRLRDYVRKDN--------HVY 795
              .:.:..||.....::...||....|......::    |:..:.::|.::||.        .::
Worm  2231 --KKRDEPTALIPRHIIDRLNDVKPKVTFDVSDEIMDDGEDKMKAVQDALKKDMSEARKLRIRMF 2293

  Fly   796 NE-ELKMQRF 804
            |. :|||::|
Worm  2294 NSMDLKMKKF 2303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUBAI	NP_610784.1	UCH	358..738	CDD:278850	80/502 (16%)
DUBAI	NP_610784.1	Peptidase_C19H	359..739	CDD:239129	80/502 (16%)
T24B8.7	NP_495931.4	UBA	133..168	CDD:197551
		peptidase_C19C	1819..2234	CDD:239124	82/512 (16%)
		UCH	1819..2229	CDD:278850	80/502 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166324
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840