DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DUBAI and usp35

DIOPT Version :9

Sequence 1:	NP_610784.1	Gene:	DUBAI / 36361	FlyBaseID:	FBgn0033738	Length:	852	Species:	Drosophila melanogaster
Sequence 2:	XP_002936594.2	Gene:	usp35 / 100498476	XenbaseID:	XB-GENE-954095	Length:	997	Species:	Xenopus tropicalis

Alignment Length:	960	Identity:	241/960 - (25%)
Similarity:	395/960 - (41%)	Gaps:	301/960 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LLAYLQSIDMPEQGHNVMAICERVIVDLARLQIPRGASCPRLKEDVCQVGAFLATRNE------- 129
            |::|.|.|  |...|.|: .|:::|..:.:..      |....|:  .:..||...|.
Frog   151 LVSYPQCI--PAGKHQVL-FCQQLIRSIGQFH------CSSQAEE--YIVQFLDQVNRVCGLLQK 204

  Fly   130 --KFHQMFYLRVVYELI----TKSPFEPPPSCAVAIVFQLFDSTQILEAVHSLL--EQNVQDSSI 186
              .|.....|..:.||.    :...:|.|.:|..::|  .:...:::|.|...|  ..:|.|..|
Frog   205 IWSFQTSLVLPCLKELFAIISSTDEYEAPSNCLASVV--QYIPLELMEGVVKNLANADSVSDIQI 267

  Fly   187 KKTVNLLCDWITYCTFCSTLNLWVLALLKGLRDQGKMALLDEIAMDNIEKLFHVMIFPALRQKAA 251
            ...::.:.||::: .....::.|::||||.|....|.::|.|:::..|:|:|..:::|.||..|.
Frog   268 MAAISRMIDWVSW-PLGKNIDKWIIALLKALAAVKKFSILIEVSLSKIQKVFSKLVYPVLRDGAL 331

  Fly   252 PVVFHMLSTINQTPEVFHKILPRIPRVLQYVKNQSTTMDEIGLETKKCLQQLVDLTSALMLRFYD 316
            .|:.:||.:...:||.||.|:|.||:::.::.|:::.      ....||:.:.:|...::.||..
Frog   332 SVLRYMLLSFQHSPEAFHLIIPHIPQLILHLSNENSN------SATNCLEHIAELIHCMIFRFSG 390

  Fly   317 QDELYVATKKALQTYEPSPNCVALAKAMHENAQPW-GRRN---------------ARVGLVNLGN 365
            ..:||....:|::.. |.||...:...:.:||  | .::|               .::||:||||
Frog   391 YPDLYEPIMEAVRKL-PVPNEERIKVLLGQNA--WTAQKNELAAYYPRLASKSDTGKIGLLNLGN 452

  Fly   366 TCYMNSVLQALAMTSDFSRQIL-LIECNS-VLLMKVQQQIALMHHSLRYELTPSRVLNATRPPSF 428
            ||||||:||||.|.|||...:| |.|.:| .|:||:|...|.:.||.|..::|:..|.:..||.|
Frog   453 TCYMNSILQALFMASDFRHAVLSLKETHSQPLMMKLQCLFAFLEHSQRPAISPANFLASFLPPWF 517

  Fly   429 TPGLQQDSSEFLGYLLDLLHEHEINSSSVTGHSVGPPKTGREVDDVPALLSEDILSSGVIPYNSK 493
            |||:|||.||:|.||||.|||.|              |||:.:            |..:...||
Frog   518 TPGVQQDCSEYLKYLLDRLHEEE--------------KTGKRI------------SQALAQTNS- 555

  Fly   494 DHELSSGSNSDNCNHKPTPTPPATPTKATNGLKQQGQQVDQAKPPSTIDKTFAGKLSTTYRCLNC 558
                |||......:|:                             :.:::.|.|:::|..|||.|
Frog   556 ----SSGVKKTMASHR-----------------------------TLLEQMFGGRITTKIRCLKC 587

  Fly   559 GWESRNEDSFRELQLSFP----------------------------------------------- 576
            ...|..|:.|.:|.|:||
Frog   588 HSVSSREEVFTDLSLAFPPTNEAAKQLPQPLSAGESGPQKSDLTCKVQEPQVTNSPETVRRQWRT 652

  Fly   577 ---------------------------DDKEDC---------GAT----------NYSVQDLIEY 595
                                       .|:.:|         .||          :.|:.|||.:
Frog   653 NDPPPGETSEFSRNVDKADPFISRLESQDENNCSIVRNKNLLSATLKEGTGGQRGSLSLSDLINH 717

  Fly   596 YCSPEKLDGDNQYFCPQCKKLCDAERHIGVTQAPKNLILTLKQFKYDQKYHFRTKLMHKVFHDES 660
            :..||.|..||:|.|..|..|.|||:.:.:|..|:.|||||.:|.:|.|...|.|::      ::
Frog   718 FLCPEMLTADNKYRCDTCVSLQDAEKVVELTTGPQYLILTLLRFSFDLKAMKRRKIL------DN 776

  Fly   661 VTVKMSAKDSLQ----EMSTVH---------------YDLYAGVVHAGYSMDSGHYFTFAADQAK 706
            |::.:..|..:|    |::..|               |||.:.:||:|.|.::|||:.:|.|..:
Frog   777 VSIPLVLKLPIQVAGTELNDAHFGKDSRCKATKESVTYDLCSVIVHSGLSSETGHYYCYARDCLE 841

  Fly   707 ------------------------NWYKFNDNVVTHSKPEEMHNLTS---PNTPYILFYK----M 740
                                    .||.|||..|:.|..|.:.|:||   .:|.|:||||    .
Frog   842 KDNRKPPSTGVKKLNPDKHLDLEIQWYLFNDTRVSFSSFESVSNVTSFFPKDTAYVLFYKHRPQQ 906

  Fly   741 CGHSNESNSVTASCSSSMVSGSNDQVVSVPLSPPLKLEELPRRLRDYVRKDNHVYNEELKMQRFK 805
            .|.|::..:..|.        |:.:|            .|.:.|.:.:.|||..|.:|.:.:...
Frog   907 AGPSSDLEAAVAL--------SHGEV------------SLSKELMEAISKDNIKYLQEQEKEARN 951

  Fly   806 RGNSGHGNAFVSR--------HNFDGDGDEDDKAPP--PPGGCGGNGLGM 845
            |      :|::|.        .::|.|.|:|..:..  |.||..|:..|:
Frog   952 R------SAYISPLLKSPLWWQDYDKDSDDDGSSGSLGPAGGGSGSFHGL 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DUBAI	NP_610784.1	UCH	358..738	CDD:278850	141/520 (27%)
DUBAI	NP_610784.1	Peptidase_C19H	359..739	CDD:239129	142/520 (27%)
usp35	XP_002936594.2	Peptidase_C19	446..901	CDD:351799	142/520 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I3731
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H35459
Inparanoid	1	1.050	259	1.000	Inparanoid score	I3046
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D431768at33208
OrthoFinder	1	1.000	-	-		FOG0004017
OrthoInspector	1	1.000	-	-		otm47982
Panther	1	1.100	-	-	O	PTHR24006
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3301
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160