Protein Alignment Nup54 and npp-1

DIOPT Version :10

• Sequence 1: NP_610783.1
• Gene: Nup54 / 36360
• FlyBaseID: FBgn0033737
• Length: 610
• Species: Drosophila melanogaster
• Sequence 2: NP_501770.1
• Gene: npp-1 / 177836
• WormBaseID: WBGene00003787
• Length: 639
• Species: Caenorhabditis elegans
• Alignment Length: 701
• Identity: 194/701 - (27%)
• Similarity: 288/701 - (41%)
• Gaps: 175/701 - (24%)

  Fly     1 MSFFGSNT------SLGATSTPAKTTGGLFGSP------FGGTAATSQPAPAFGAQATSTPAFGA 53
            ||.|||:|      :....:.|..::|.||||.      ||.||..|.....||...||||
 Worm     1 MSLFGSSTPQKQAFTFPTPNAPTTSSGTLFGSTTPSKPLFGSTAQASSTPSLFGTTNTSTP---- 61

  Fly    54 QPATSAFGAGSAFGATAAAPAFGAATGTSAFGGSAFGSTPA--------FGAATTTTAGT-GLGG 109
                    :|..||.|      |.:|.|::..|:.||:.|.        |||:||...|| ....
 Worm    62 --------SGGLFGKT------GTSTTTTSTAGTLFGAAPTTSTATPSLFGASTTGLFGTSSTTS 112

  Fly   110 GGFGGFGAAPATS-----------QAGLFGA-------PATSAAPPAFSGFGQQAAASTAPASGF 156
            ||.||.|:...|:           ::|..||       |.:.|.|.|..|       :.||.|.|
 Worm   113 GGLGGIGSTQQTAKSPVATRLAAFKSGTLGAGSLSGNTPTSFATPSALPG-------TNAPQSSF 170

  Fly   157 SGFGTTTTSAPA--------FGG---FGTSQSTGFGGGA--FGSTFGKPANTTVTPGFGG--FGG 206
            .........|||        |||   ||.: |||...|:  |||:..|||    |.||.|  .|.
 Worm   171 LSPANNLNVAPAAYRPPYSTFGGSTPFGAA-STGTAAGSTLFGSSTAKPA----TGGFFGSSSGS 230

  Fly   207 TSFMLGQPQQQPAPISADE-------AFAQSILNVSIFGDERDKIVAKWNYLQATWGTGKMFYSQ 264
            |...||..|||..|:...:       .|.:::.:..:||::.|.:|||.|.:.|..|.||..|..
 Worm   231 TLGGLGATQQQQQPVVQQQQVIQQYHPFVKAVGDPKLFGNDNDGVVAKLNQVAAGLGVGKAPYKD 295

  Fly   265 SAAPVDITPE-NVMCRFKAIGYSRMPGKDNKLGLVALNFCRELSAVKPHQQ--QVIQTLHSLFGS 326
            ....:..:.| |:..||..|||:|:..:.:..|.|.|.....::.:...::  ::::.:.::.|.
 Worm   296 GNQLLSFSMEGNLFERFVGIGYNRISERTDDEGFVTLVLRHPITNLNTEERRDKILEIIKAILGG 360

  Fly   327 KPNMLVHIDSIKELENKKCQIVIYVEEKLQHAPNESKRIL-------------------ATELSN 372
            .||:                       ::::||..|.|.|                   |.:|:.
 Worm   361 GPNV-----------------------EVRYAPGTSMRTLSDGCTEICIIAKEGGFVAGAIKLAQ 402

  Fly   373 YLNQATLKPQLNNLGVVEALALVLP----DEDQLREYLENPPRGVDPRMWRQANSDNPDPTLYIP 433
            .||.|....||.:...|:. ..|||    .:.|...|||..|.|:|.|:||||..:||.|...:|
 Worm   403 ILNDAPKMTQLESQLQVDK-TRVLPKVGMSKAQRDRYLETVPDGIDERIWRQAIKENPAPNKLLP 466

  Fly   434 VPMVGFNDLKWRVKCQEQETDTHALYIKKVESELTELKKRHATATAK--ILEHKRKLAELSHRIL 496
            ||:.|:..|:.|.|.|..|:......|..:.:.:.|....||.|..|  |:.::.|  .||:||:
 Worm   467 VPVRGWEALRDRQKAQVGESKLFHEAINALGNRVEEANHEHADAVVKMEIIRNRHK--TLSYRIV 529

  Fly   497 RIIVKQECTRKVGTSLTPEEEALRTKLQNMLAVVSAPTQFK---GRLSELLSQMRMQRNQFAANG 558
            |:::.|....:....:..:|:.:..|...:||.::...|.|   .:..|:|
 Worm   530 RVMLAQWIVSRYSRQIDTDEDVIEAKADTLLAQMNRHNQVKFYVDKFYEIL-------------- 580

  Fly   559 GAEYALDKEAEDEMKTF-LTMQQR--AMEVLSDTVNKDLRALDVIIKGLPE 606
              |...||..|...|.| :|::..  |..||:..||        |..||.|
 Worm   581 --ESKPDKLQESMWKMFDMTIEDEHYARRVLTKFVN--------ICSGLYE 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup54	NP_610783.1	Nucleoporin_FG	2..91	CDD:463941	31/100 (31%)
		Nucleoporin_FG	125..220	CDD:463941	41/116 (35%)
		Nup54	409..546	CDD:464011	42/141 (30%)
		Nup54_C	562..600	CDD:465767	11/40 (28%)
npp-1	NP_501770.1	Nucleoporin_FG	2..106	CDD:463941	38/121 (31%)
		Nucleoporin_FG2	5..>216	CDD:435043	71/236 (30%)
		Nup54	443..577	CDD:464011	40/135 (30%)