Protein Alignment INPPL1 and INP54

DIOPT Version :10

• Sequence 1: NP_001427363.1
• Gene: INPPL1 / 3636
• HGNCID: 6080
• Length: 1280
• Species: Homo sapiens
• Sequence 2: NP_014576.1
• Gene: INP54 / 854089
• SGDID: S000005426
• Length: 384
• Species: Saccharomyces cerevisiae
• Alignment Length: 345
• Identity: 96/345 - (27%)
• Similarity: 140/345 - (40%)
• Gaps: 85/345 - (24%)

Human   448 VFIGTWNMGSVPPPKNVTSWFTSKGLGKTL-----DEVTVTIPHDIYVFGTQE------------ 495
            |.:.|:|.|...|.:|      ||.:.|.|     |.::.....|:||.|.||
Yeast     8 VSVTTFNCGKEFPVEN------SKAIVKQLLFPYDDGISQLELQDLYVLGFQEVVPIWQGSFPAV 66

Human   496 -NSVGDR----------EWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVST 549
             ..:.||          |.:...:|      |..|..:.:.||..|.:.||    :.|....|..
Yeast    67 NRDLIDRITTTAVNCLNEKVSATQG------DEQYSCLGVNSLGAITIIVL----YNNNALKVKD 121

Human   550 SSVK-TGIANTLGN--KGAVGVSFMF------NGTSFGFVNCHLTSGNEKTARRNQNYLDILRLL 605
            ..:| .|.....|.  ||...:||..      |...|.::..|| :.||....|||...|..|::
Yeast   122 DILKRNGKCGWFGTHLKGGTLISFQMTRNGEENWERFSYICAHL-NANEGVNNRNQRIDDYKRIM 185

Human   606 S-LGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRKEFEPLL-RVDQLNLER--EKH 666
            | :.|.::...|      |.|:.||||:|:........||.|......|| ..::|||.|  |..
Yeast   186 SEVCDSEVAKSD------HFFFLGDLNFRVTSTYDPTTNYSSTTTLRRLLENHEELNLLRKGEDE 244

Human   667 KVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYP--------ETH 723
            .:...|.|.:|:|||||:::...::||...:         :||||||||:|||.        ..|
Yeast   245 PLCKGFQELKITFPPTYKFKLFEKETYNTKR---------IPSWCDRILYKSYAVPTFAQEGTYH 300

Human   724 IICNSYGCTDDIVTSDHSPV 743
            .:..|    :.::.|||.||
Yeast   301 SVPRS----NALLFSDHQPV 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPPL1	NP_001427363.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	919..1140
		SH3-binding	966..971
		NPXY motif	1005..1008
INP54	NP_014576.1	COG5411	1..371	CDD:227698	96/345 (28%)