Protein Alignment INPPL1 and kap123

DIOPT Version :10

• Sequence 1: NP_001427363.1
• Gene: INPPL1 / 3636
• HGNCID: 6080
• Length: 1280
• Species: Homo sapiens
• Sequence 2: NP_596729.1
• Gene: kap123 / 2539863
• PomBaseID: SPBC14F5.03C
• Length: 1067
• Species: Schizosaccharomyces pombe
• Alignment Length: 1072
• Identity: 196/1072 - (18%)
• Similarity: 335/1072 - (31%)
• Gaps: 355/1072 - (33%)

Human   207 YLK--GSYGLDLEAVRGGASHLPHLTRTLATSCRRL-H---SEVDKVLSGLEILSKVFD------ 259
            |||  ||. |.|..:.|...: |.:.:..|...|:| |   |.||..:.. :|.|.:.|
pombe    35 YLKEPGSL-LSLFHIMGTCEN-PQVRQLAAIEARKLCHKYWSSVDADVQN-QIRSNLLDITLKEP 96

Human   260 ----QQSSPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKAL--------------K 306
                :.:...|...|.:.:||:....||.:.:::.::  |....|::.|:              |
pombe    97 ESIVRHAFGRVIAALAKLDLPEGKWNELSAFLVQATM--DQNDSIREMAVYVLYSIAETVDLDNK 159

Human   307 ALQDMSSTAPPAPQPSTRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLR-- 369
            .|.|..:........|:|..:...||......:|...|..|:..:.:.||.     |.|::|:
pombe   160 LLLDFVNLFSQTITDSSRTVRVTSVQGLGAIAEVLESDDKKLLHAYRATLP-----GMLLVLQDV 219

Human   370 -------RQRDSQEDWTTFTHDRIRQLIKSQRVQNK-LGVVFE--------KEKD---RTQRKDF 415
                   ..:...:.:.||       ||.|..:.:| ||.:.|        |:.|   |.....|
pombe   220 VQVGDVDASKQVFDVFNTF-------LIASGAIISKALGNIIEIITGIANSKQVDDEIRCMALSF 277

Human   416 IFVSARKREAFCQLLQLMK--------------NKHSKQDEP--------DMIS----------- 447
            |....|.:....|.|:|.|              .....:|.|        |::|
pombe   278 IISCIRFKSRKLQALKLGKPLVLTLMEVATEETTDDIDEDCPARLALRSIDLLSTHLSPSQVFYP 342

Human   448 VFIGTWNMGSVPPPKNVTSWFTSKGLG-----------------------------------KTL 477
            :|.........|......:...|.|:.                                   ..|
pombe   343 MFEAACAFSQSPQASYRKAALLSIGVAVEGSSESVAGNLPNIFPIIINGLCDNDMDVRQAALLAL 407

Human   478 DEVTVTIPHDI---------YVF---GTQENSVGDR--EWLDLLRGGLKELTDLDYRPIAMQSLW 528
            .::.|.||.::         .||   .||...||..  ..:|.|..||.:.....|.|:.|:.|.
pombe   408 SQIAVEIPTEVSKHHAQLLPLVFELMSTQGVKVGKSACNCIDALLEGLDKSEISGYLPMLMERLV 472

Human   529 NIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKG-AVGVSFM--FNGTSFGFVNCHLTSGNEK 590
            .:             :....|..:|:.:|..:|:.. |....|:  |..|......|..|:.:::
pombe   473 GL-------------LEFSDTPDIKSCVAAAIGSAAFAAQDDFIPYFERTMASLSQCLHTTDDDE 524

Human   591 TARRNQNYLDILRLL--SLGDR----------QLNAFDISLRFTHL----FWFGDLNYRLDMDIQ 639
            ........:|.|..:  ::|.:          ||....|.:..:.|    |.|           .
pombe   525 GYELRGTVMDTLGAIANAVGKQAFLPYTEQLIQLAYEGIQIDHSRLRECSFCF-----------Y 578

Human   640 EILNYISRKEFEPLLR---------VDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAW 695
            .:|..:.::||.|.|.         :||...:....::....:||......:........|.
pombe   579 AVLARVYKEEFAPFLEHIVPALFKSIDQDESDILSERIGAPTAEEISQLLDSVETNEEENDE--- 640

Human   696 HKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVF-GTFE--VGVTSQF-- 755
            ..:|..||.:.:..           |..|..::.|.....|.:..:|.. .|.|  |..|:.|
pombe   641 ELEKAMGVNSAIAM-----------EKEIAADALGEICMYVGAPFTPYLEPTVEKLVACTTHFYE 694

Human   756 -ISKKGLSKTSDQAYIEF-------------------ESIEAIVKTASRTKFFIEFYSTCLEEYK 800
             :.|..||.....|...:                   ::::.|.:...:..|     .|..|||:
pombe   695 GVRKSALSSLWRCATTYYKVCNVPQWQPGLPLKVPVPDTVKNIFEAVRKCTF-----DTLEEEYE 754

Human   801 KSFENDAQSSDNINFLKVQWSSRQLPTLKP-ILAD---------IEYLQDQHL------------ 843
            |:...|...    ||      :..:.|..| :|.|         :|.||.||:
pombe   755 KTVATDILR----NF------AESIKTCGPVVLGDDYEKLCEVVMEVLQKQHIVQAGDVFDDDFE 809

Human   844 ---LLTVKSMDGYE-------SYGECVVALK-SMIGSTAQQFLTF--------LSHRGEE----- 884
               :::.:.:|..|       |..:.|:||. ::.||.|..|..|        :|..|.|
pombe   810 EEDIVSNEEVDDTEQDALLIDSACDVVIALAVALGGSFADSFKVFYPQIVKYYMSKNGNERAMAV 874

Human   885 --TGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKSKAPSVSRG-----SQEPRSG----- 937
              .|.:.|.::..:..   .||:....:::..:|..|......:.|.|     |.|..|.
pombe   875 ACVGEVAGGIESAITP---FTRDVFSLFMAALEDSEGEVRSNAAYSMGLLCQFSTEDLSSEYLNI 936

Human   938 --SRKPAFTE----------ASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPE 990
              ..:|.||:          ..| :|||....:            .|.|.::.|
pombe   937 LQKLQPFFTQEVFRTALDNAIGC-ISRLILHNQ------------NAIPVDQVL----------- 977

Human   991 PEGVAAPPPKNSF--NNPAYYVLEGVPHQLLP 1020
            |...:..|.|..:  |.|.|:::..:..|..|
pombe   978 PIVFSKLPLKEDYLENAPLYHMILALYRQQNP 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPPL1	NP_001427363.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	919..1140		24/126 (19%)
		SH3-binding	966..971		0/4 (0%)
		NPXY motif	1005..1008		1/2 (50%)
kap123	NP_596729.1	HEAT repeat	42..67	CDD:293787	5/26 (19%)
		KAP95	54..687	CDD:227540	119/686 (17%)
		HEAT repeat	79..113	CDD:293787	5/34 (15%)
		HEAT repeat	123..153	CDD:293787	5/31 (16%)
		HEAT repeat	163..189	CDD:293787	5/25 (20%)
		HEAT repeat	340..371	CDD:293787	4/30 (13%)
		HEAT repeat	383..413	CDD:293787	1/29 (3%)
		HEAT repeat	424..450	CDD:293787	6/25 (24%)
		HEAT repeat	854..882	CDD:293787	5/27 (19%)
		HEAT_EZ	870..921	CDD:463906	8/53 (15%)
		HEAT repeat	894..924	CDD:293787	4/29 (14%)
		HEAT repeat	933..962	CDD:293787	4/29 (14%)