Protein Alignment INPPL1 and unc-26

DIOPT Version :10

• Sequence 1: NP_001427363.1
• Gene: INPPL1 / 3636
• HGNCID: 6080
• Length: 1280
• Species: Homo sapiens
• Sequence 2: NP_001023266.1
• Gene: unc-26 / 178284
• WormBaseID: WBGene00006763
• Length: 1119
• Species: Caenorhabditis elegans
• Alignment Length: 1302
• Identity: 287/1302 - (22%)
• Similarity: 455/1302 - (34%)
• Gaps: 391/1302 - (30%)

Human    21 WYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALC---------VLYQKHVHTYRIL---- 72
            |...| :|.....|:.:.|.|||.|.:     .||.|..         ..|||.|..|.||
 Worm     9 WRRND-ARFQPSILVEKNGLDGSLLFQ-----GGAIATLDSDSTDVERRSYQKIVDAYGILGVLA 67

Human    73 --PD-----------------GEDFLAVQTSQGVPVRRFQTL----GELIGLY-AQPNQGLVCAL 113
              .|                 |.|.|.:...:.:.:|.|.::    ..:|.|. ...:|....:.
 Worm    68 ITKDEAVLVAVTGVLSVGQLYGADILKITNVEFISLRTFGSVENVDSRIIDLQRLLSSQMFYFSS 132

Human   114 LLPVEGEREPDPPDDRDASDG-----------------EDEKPPLPPRSGS-----TSISAPTGP 156
            |...:..|.....|..|.||.                 :.:...|...:||     ..:.|.||.
 Worm   133 LQSYDLTRSAQHRDSHDCSDARFFWNRSLHFSFQRYGIDTDNWLLKCMAGSVLVRVVYVGANTGR 197

Human   157 SSPLPAPETPTAPAAER-------DGAEVLGQVSRTSTDFLTPPQSAPNGLSTVSHDYLKGSYGL 214
            .:.:      :..:.||       .||..||.|:    :|:...|.........|...::||..|
 Worm   198 VALI------SRLSCERVGTRFNVRGANYLGNVA----NFVETEQLLLFDEKECSLLQIRGSIPL 252

Human   215 DLE--AVRGGASHLPHLTRTLATSCRRLHSEVDKV---------------LSGLEILSKVFDQQS 262
            ..|  .|..| ||...| |...||....|..:.::               ..|..:|...|..|.
 Worm   253 FWEQPGVNVG-SHKVKL-RAFETSLPAYHRHLSQLQHRYGEFAIVNLLGRKEGERVLGDAFKTQH 315

Human   263 -----SPMVTRL-LQQQNLPQTGEQELESLVLKLS---VLKDFLSGIQKKALKALQDMSSTAPPA 318
                 :|:|..: .......:..::.:..|..|:|   ....|...:.|:.:|
 Worm   316 KSSHFAPLVDFIDFDYHAQMKISKEAIVQLKKKMSPHMTKHGFFYSMGKEIVK------------ 368

Human   319 PQPSTRKAKTIPVQAFEVKLDVTLGDLTKIG--KSQKFTLSVDVEGGRLVLLRR---------QR 372
                 |:...|.....:. ||.|....|.||  .|......:::..|::.:.:|         |:
 Worm   369 -----RQTGVIRTNCLDC-LDRTNAVQTAIGLQMSHDQVAFLNLNAGKVNVEQRVEEILRDLWQK 427

Human   373 DSQEDWTTFT-----------HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDF-IFVSA----- 420
            :..:..|.:.           .|..|.|.::  :||.|       .|..:::.| :|::.
 Worm   428 NGDQCSTIYAGTGALDGKSKLKDASRSLART--IQNNL-------MDGAKQESFDLFLTGAAYDP 483

Human   421 RKREAFCQLL--QLMKNK---HSKQD-------------EPDMISVFIGTWNMGSVPPPKNVTSW 467
            |..:..|.:|  .|::..   |...|             ||..|.:|:||||:..
 Worm   484 RLFDRACNILPPSLIQESYYYHEYADAVSQLVERSPEIAEPQSIKIFVGTWNVNG---------- 538

Human   468 FTSKGLGKTLDEVTV----TIPHDIYVFG-TQENSVGDREWLDLLRGGLKELTDLD--------- 518
                  ||.:..|..    ::.|.|:... |:..||.|.:..|::..|::||.||:
 Worm   539 ------GKNIHNVAFRNESSLSHWIFANSMTRLVSVEDEQLADIVAIGVEELVDLNASNMVKAST 597

Human   519 -------------------YRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKG 564
                               :..|..:.|..:.:.:..:|.....:...:.:|||||:....||||
 Worm   598 TNQRMWCESIRKTLSEKAPFVLIGSEQLVGVCLFLFARPRVSPYLKDFAVASVKTGMGGATGNKG 662

Human   565 AVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLL--SLGDRQLNAFDISLRFTHLFWF 627
            :|....:...||..|:..|..:|..:...||:::...|:.:  .|| |::::.|:      :||.
 Worm   663 SVAFRIVVFSTSICFICSHFAAGQNEIRDRNEDFATTLKKIRFPLG-REIDSHDV------IFWL 720

Human   628 GDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDT 692
            ||.|||:::...|:.|.:...::..|:..|||..::...:.|:.|:|.:::|.|||:|:..| |.
 Worm   721 GDFNYRINLSGDEVKNAVRNGDYAKLVENDQLTQQKALGQTFVGFNEGQLTFAPTYKYDTFS-DD 784

Human   693 YAWHKQKPTGVRTNVPSWCDRILWKSY---PETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQ 754
            |      .|..:...|:|.||||||..   .:|.::  ||. ..::.||||.||...|:| .|.:
 Worm   785 Y------DTSEKCRAPAWTDRILWKDQRKKGKTQLL--SYD-RSELKTSDHRPVGAVFKV-ETFK 839

Human   755 FISKKGLSKTSDQAYIEFESI-----EAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNIN 814
            ...:|.:....|..    ||:     ..||..|.:.:|..:.:....|:.|   |..||
 Worm   840 VGGRKCVELIEDVV----ESMGPPDGTIIVSIAGKPRFPPQMFPPIHEKLK---ELGAQ------ 891

Human   815 FLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLS 879
               ||.|......|..:|...|      :.|...||||.:..|...:.:|......|......||
 Worm   892 ---VQLSKFDDGDLWIVLNSGE------MALAALSMDGLKIGGTDQINVKLKSPDWAYALKPHLS 947

Human   880 HRGEETGNIRGSMKVRVPTERL--GTRERLYEWISIDKDEAGAKSKAPSVS----RGSQEPRSGS 938
            ....|      |.:|....|.|  ||...::|:...|:|       |.|||    .||...|  .
 Worm   948 DFDLE------SFEVTAEEEALLGGTDGAVFEFADEDED-------AISVSSLTLTGSAPDR--P 997

Human   939 RKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPRE----------EPLTPRLKPEGAPEPEG 993
            |.|:....:..:::| |.|.:.|.......|.||:...          .||.|       |:...
 Worm   998 RPPSARSEAISVAKL-EWPTEQPNVLSTSMPTRASSASLANSSWYEHVPPLAP-------PQSNN 1054

Human   994 VAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGE 1058
            ..:||....||               |....:|:.||.||        |:|.|..   |...||.
 Worm  1055 NKSPPQACLFN---------------PFTQSAPSPAPPPS--------TIPLPPT---RGASVGP 1093

Human  1059 GSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPP 1123
            |                 ||.:|                 ||       :.||||   |||.:||
 Worm  1094 G-----------------PPAVP-----------------VR-------KAPPPP---PRPVIPP 1114

Human  1124 GP 1125
            .|
 Worm  1115 RP 1116

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPPL1	NP_001427363.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	919..1140		52/221 (24%)
		SH3-binding	966..971		1/4 (25%)
		NPXY motif	1005..1008		0/2 (0%)
unc-26	NP_001023266.1	COG5329	50..484	CDD:227637	85/472 (18%)
		INPP5c_Synj	527..835	CDD:197323	89/340 (26%)
		RRM_SF	850..978	CDD:473069	36/155 (23%)