Protein Alignment INPPL1 and ocrl-1

DIOPT Version :10

• Sequence 1: NP_001427363.1
• Gene: INPPL1 / 3636
• HGNCID: 6080
• Length: 1280
• Species: Homo sapiens
• Sequence 2: NP_001361846.1
• Gene: ocrl-1 / 172822
• WormBaseID: WBGene00007620
• Length: 712
• Species: Caenorhabditis elegans
• Alignment Length: 519
• Identity: 141/519 - (27%)
• Similarity: 206/519 - (39%)
• Gaps: 128/519 - (24%)

Human   446 ISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDI---YVFGTQEN--SVGD----- 500
            :.:.:.|:|:....|.....:||:.|             |.||   |..|.||.  |||.
 Worm    39 VKICVSTFNVNGRSPLSVFPTWFSQK-------------PEDIAEFYAVGLQEMDLSVGTYIIDN 90

Human   501 ----REWLDL----LRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIA 557
                ..|:|.    |.||..:     :..:....|..|.|.|......:.|:|.|:...|.|||:
 Worm    91 TKKMEGWVDAIHCSLPGGRTQ-----FNVVGSMRLVGIFVIVFQAVNSKVRVSDVNVKYVATGIS 150

Human   558 ---NTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLL---------SLGDR 610
               |.|||||...||...|.|...|||.|..:||.:..||||::.||...:         .|.||
 Worm   151 VLVNKLGNKGGTAVSMKMNDTWVCFVNAHFAAGNNELERRNQDFRDIYNDMVFYPRSQQEGLRDR 215

Human   611 QLNAFDISLRFTH--LFWFGDLNYRLDMDI-----QEILNYISRKEFEPLLRVDQLNLEREKHKV 668
            .|.. .|...:.|  :||||||||||:.|:     .|:....|..:|..||:..||..:..:..|
 Worm   216 PLEV-PIMCLYDHDVVFWFGDLNYRLNTDMYGISNDEVRRIASSDKFADLLQHCQLREQMARGTV 279

Human   669 FLRFSE-EEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRIL-WKSYPETHI-ICNSYG 730
            |..|.| ..:.|.|||:|:.|   |..|    .|..:..||:|.|||| :|.||:..: ......
 Worm   280 FKDFEEPSTLPFRPTYKYDCG---TNTW----DTSEKGRVPAWTDRILTFKKYPQVGLESIRPMV 337

Human   731 CTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQA--------------------------- 768
            ..|.|..|||.||...|.:.|..  |::.|.:...::|
 Worm   338 SIDTITISDHKPVRAMFNLKVKK--INESGANNVYEEAIREADRRANEELPQVQLSLNEVDFGIV 400

Human   769 -YIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNI--NFLKV--------QWSS 822
             |:|.::...||:...::|....|          ....:|:::..|  .:|.|        |.||
 Worm   401 NYLEPKTRSVIVQNVGKSKVRFSF----------KVRPNARNNQEICEKWLMVTPTHYQIPQGSS 455

Human   823 RQLPTLKPILADI-EYLQD-------QHLLLTVKSMDGYESYGECVVAL--KSMIGSTAQQFLT 876
            .::.....|..|| ..:||       |.:|  |..::....|...:.|:  .|..|||.::.|:
 Worm   456 MEISLTVSISTDIVRRIQDLIRNGQLQEIL--VLHLENGRDYFIPITAVYNNSCFGSTLEKLLS 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPPL1	NP_001427363.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	919..1140
		SH3-binding	966..971
		NPXY motif	1005..1008
ocrl-1	NP_001361846.1	INPP5c	39..356	CDD:197308	109/342 (32%)
		RhoGAP_OCRL1	496..705	CDD:239845	6/22 (27%)