DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8520 and AFG1

DIOPT Version :9

Sequence 1:	NP_001188911.1	Gene:	CG8520 / 36357	FlyBaseID:	FBgn0033734	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_010862.1	Gene:	AFG1 / 856658	SGDID:	S000000778	Length:	509	Species:	Saccharomyces cerevisiae

Alignment Length:	483	Identity:	159/483 - (32%)
Similarity:	235/483 - (48%)	Gaps:	75/483 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LSPLKEYEKRVSSGQLMTDNRQLQTMKELDALYHKIQGYKPSY--------RAGGGGGGFFSSIF 86
            |:||:||::.|..|:|..|..|...:..|..||..:..|.|..        :.||...| ..|:|
Yeast    34 LTPLQEYDRLVKLGKLRDDTYQRGIISSLGDLYDSLVKYVPPVVKTPNAVDQVGGWLNG-LKSVF 97

  Fly    87 GR-KSSTEDDDQDDPNAGSHAPQGLYLYGSVGVGKTTLMDLFFDCCTQIHRKQRVHFTSFMNTVH 150
            .| |........|....|:..|:|:||||.||.|||.|||||:........|:|:||..||..||
Yeast    98 SRGKPKNIGAYVDVSKIGNSIPRGVYLYGDVGCGKTMLMDLFYTTIPNHLTKKRIHFHQFMQYVH 162

  Fly   151 TRIHEAKQRQGPVDRAFNSEKPAPFDPTKPVADLIASESWLICFDEFQVTDIADAMVLKRLFTHL 215
            .|.||..:.|..  :.....|....|....:|..||:.|.::|||||||||:||||:|:||.|.|
Yeast   163 KRSHEIVREQNL--KELGDAKGKEIDTVPFLAAEIANNSHVLCFDEFQVTDVADAMILRRLMTAL 225

  Fly   216 FR--HGIVVVATSNRHPEDLYKNGLQRTNFLPFIALLQRRCKVSQLDS-IDYRRIAQ-------- 269
            ..  :|:|:.|||||||::||.||:||.:|:|.|.|::.|.||..|:| .|||:|.:
Yeast   226 LSDDYGVVLFATSNRHPDELYINGVQRQSFIPCIELIKHRTKVIFLNSPTDYRKIPRPVSSVYYF 290

  Fly   270 SGDT---------------------NYFVK-GQTDADGSMNRMFKILCAEENDIIRPRTLTHFGR 312
            ..||                     |||.: ..||.....:.:.|        ......||.:||
Yeast   291 PSDTSIKYASKECKTRRETHIKEWYNYFAQASHTDDSTDSHTVHK--------TFYDYPLTIWGR 347

  Fly   313 DLTFNR-TCGQVLDSTFSELCDRPLAGSDFLQISQFFHTVLIRDVPQLTLDVKAQMRRFITLIDT 376
            :....: |..:|...||.:||..|||..|:|.:::.|...::.|:|.|::.|:.::|||||.:|.
Yeast   348 EFKVPKCTPPRVAQFTFKQLCGEPLAAGDYLTLAKNFEAFIVTDIPYLSIYVRDEVRRFITFLDA 412

  Fly   377 LYNNRVRVVISSDVALENLFSFTGGSKTLSDSE------------RTLMDDLNIKE-------SK 422
            :|::..::..:......:|  |....:.|:|.|            ..::|::..|.       .|
Yeast   413 VYDSGGKLATTGAADFSSL--FVEPEQILNDFELRPTTKEPDSVDTGMVDEMVEKHGFSKEIAKK 475

  Fly   423 ASFFTGEEELFAFDRTLSRLYEMQKREY 450
            :..|..:||.|||.|.||||.:|...::
Yeast   476 SQMFALDEERFAFARALSRLSQMSSTDW 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8520	NP_001188911.1	YhcM	22..450	CDD:224402	159/481 (33%)
CG8520	NP_001188911.1	P-loop_NTPase	31..450	CDD:304359	158/480 (33%)
AFG1	NP_010862.1	YhcM	35..509	CDD:224402	158/482 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346706
Domainoid	1	1.000	189	1.000	Domainoid score	I646
eggNOG	1	0.900	-	-		E1_COG1485
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5782
Inparanoid	1	1.050	217	1.000	Inparanoid score	I780
Isobase	1	0.950	-	0	Normalized mean entropy	S1327
OMA	1	1.010	-	-		QHG54198
OrthoFinder	1	1.000	-	-		FOG0003120
OrthoInspector	1	1.000	-	-		oto98962
orthoMCL	1	0.900	-	-		OOG6_101377
Panther	1	1.100	-	-	LDO	PTHR12169
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4204
SonicParanoid	1	1.000	-	-		X2090
TreeFam	1	0.960	-	-
	15	14.830