DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8520 and afg1lb

DIOPT Version :9

Sequence 1:	NP_001188911.1	Gene:	CG8520 / 36357	FlyBaseID:	FBgn0033734	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001020653.2	Gene:	afg1lb / 555926	ZFINID:	ZDB-GENE-041014-178	Length:	503	Species:	Danio rerio

Alignment Length:	463	Identity:	193/463 - (41%)
Similarity:	270/463 - (58%)	Gaps:	49/463 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 HMSGLSP-------LKEYEKRVSSGQLMTDNRQLQTMKELDALYHKIQGY--------------- 68
            |.|..:|       :..|:..|.||.|..|.:|...:.:|:.|...:..|
Zfish    45 HTSTSAPWPVYGRLVTHYDSLVHSGSLQKDPQQRTALLQLEELTRVLTDYTNIPILLPQPKDCLQ 109

  Fly    69 -KPSYRAGGGGGGFFSSIFGRKS---STEDDDQDDPNAGSHAPQGLYLYGSVGVGKTTLMDLFFD 129
             :|:.......|...:....|..   |.|.:||.:.::..|.|||.|:||:||.|||.|||||:.
Zfish   110 NQPTSELQDKVGSRETVNICRPDENVSNEKEDQQEESSKPHPPQGYYIYGNVGTGKTMLMDLFYS 174

  Fly   130 CCTQIHRKQRVHFTSFMNTVHTRIHEAKQ-----RQGPVDRAFNSEKPAPFDPTKPVADLIASES 189
             ..:..||:||||..||..||.|||:.||     |.|         |...:||..|||..||.|:
Zfish   175 -FVENRRKKRVHFNGFMLEVHRRIHKLKQSLPKRRIG---------KMTMYDPIFPVAMEIAEET 229

  Fly   190 WLICFDEFQVTDIADAMVLKRLFTHLFRHGIVVVATSNRHPEDLYKNGLQRTNFLPFIALLQRRC 254
            .|||||||||.||||||:||:||..||:.|:||||||||.||:||||||||..|:|||.:|:..|
Zfish   230 CLICFDEFQVVDIADAMILKQLFEGLFKCGVVVVATSNRPPEELYKNGLQRAAFVPFIGVLKEYC 294

  Fly   255 KVSQLDS-IDYR-RIAQSGDTNYFVKGQTDADGSMNRMFKILCAEENDIIRPRTLTHFGRDLTFN 317
            :...||: |||| |..:.....|::..:.||:.::|.:|:.|...:||:.|||.|...||::|.:
Zfish   295 RNVSLDTGIDYRTREMKPAGRLYYISSEPDAENAVNALFEELAFRQNDVTRPRVLNVQGREVTLS 359

  Fly   318 RTCGQVLDSTFSELCDRPLAGSDFLQISQFFHTVLIRDVPQLTLDVKAQMRRFITLIDTLYNNRV 382
            ||||.:.|.:|.|||::||...|:|:|::.|.||:||:||.|.|.:|.|.|||.||||..|:.:|
Zfish   360 RTCGTIADCSFQELCEQPLGAGDYLEIARCFDTVIIRNVPYLQLGMKDQARRFTTLIDNFYDQKV 424

  Fly   383 RVVISSDVALENLFSFTGGSKTLSDS-ERTLMDDLNIKE---SKASFFTGEEELFAFDRTLSRLY 443
            |||:.:|..|:.|..  .|..|..:: :|.::|:|.:.:   .:.:.||.:||:|||.||:|||.
Zfish   425 RVVMLADAPLDRLLD--QGQMTGEEARDRLMLDELGLTDEASKRMTLFTADEEIFAFQRTVSRLA 487

  Fly   444 EMQKREYW 451
            |||..:||
Zfish   488 EMQTEQYW 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8520	NP_001188911.1	YhcM	22..450	CDD:224402	191/460 (42%)
CG8520	NP_001188911.1	P-loop_NTPase	31..450	CDD:304359	189/455 (42%)
afg1lb	NP_001020653.2	P-loop_NTPase	58..494	CDD:304359	188/447 (42%)
		YhcM	59..494	CDD:224402	188/446 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..155		10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596547
Domainoid	1	1.000	308	1.000	Domainoid score	I1317
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2224
OMA	1	1.010	-	-		QHG54198
OrthoDB	1	1.010	-	-		D263573at33208
OrthoFinder	1	1.000	-	-		FOG0003120
OrthoInspector	1	1.000	-	-		otm26307
orthoMCL	1	0.900	-	-		OOG6_101377
Panther	1	1.100	-	-	O	PTHR12169
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4204
SonicParanoid	1	1.000	-	-		X2090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.030