DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8520 and SPBC115.02c

DIOPT Version :9

Sequence 1:	NP_001188911.1	Gene:	CG8520 / 36357	FlyBaseID:	FBgn0033734	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_595259.1	Gene:	SPBC115.02c / 2540093	PomBaseID:	SPBC115.02c	Length:	454	Species:	Schizosaccharomyces pombe

Alignment Length:	444	Identity:	153/444 - (34%)
Similarity:	237/444 - (53%)	Gaps:	52/444 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SPLKEYEKRVSSGQLMTDNRQLQTMKELDALYHKIQGY---------KPSYRAGGGGGGFFS--- 83
            :|::.|.|:|:.|....|..|...:|.::.||.:::.|         .|:.:     |...|
pombe    35 TPIEVYNKKVNDGVWKRDPYQETAVKAINRLYTELESYTQPPITQDSMPAEK-----GSILSWIS 94

  Fly    84 ---SIFGRKSSTEDDDQDDPNAGSH-----APQGLYLYGSVGVGKTTLMDLFF-DCCTQIHRKQR 139
               .:|.||.|        |...|.     .|:|:||||.||.|||.|||||: :....:.|.||
pombe    95 PLKKMFSRKKS--------PTLTSSLPVPGMPKGIYLYGDVGCGKTALMDLFYHNLPPNVTRSQR 151

  Fly   140 VHFTSFMNTVHTRIHEAKQRQGPVDRAFNSEKPAPFDPTKPVADLIASESWLICFDEFQVTDIAD 204
            :||.:||..||...|:.:.|.|           ...|....:|..||.|:.::||||.||||:||
pombe   152 IHFHAFMMQVHRTSHDLQDRYG-----------FEIDFIDHIASGIAKETTVLCFDELQVTDVAD 205

  Fly   205 AMVLKRLFTHLFRHGIVVVATSNRHPEDLYKNGLQRTNFLPFIALLQRRCKVSQLDS-IDYRRI- 267
            |::|:|||..|.::|:|:..||||.|.||||||:||.:|:|.|.||:.|.:|..||| .||||:
pombe   206 ALLLRRLFEALMKYGVVIFITSNRAPSDLYKNGIQRESFIPCIKLLEHRLQVICLDSPNDYRRLK 270

  Fly   268 AQSGDTNYFVKGQTDADGSMNRMFKILC-AEENDIIRPRTLTHFGRDLTFNRTCGQVLDSTFSEL 331
            :::.||..:.....:...::...|  || |:|.|......:..|||.:...:..|.|...||.:|
pombe   271 SKTEDTYLYPANSPEVKKALENWF--LCYADEKDPAHQDEVEVFGRKIIVPKASGNVAWFTFEQL 333

  Fly   332 CDRPLAGSDFLQISQFFHTVLIRDVPQLTLDVKAQMRRFITLIDTLYNNRVRVVISSDVALENLF 396
            |..|.:.:|:|.::..:|..::.|:|:|:::.|..:.||||.||.||:...::::||:|.::.::
pombe   334 CGEPKSAADYLSLASRYHVFIVSDIPKLSIESKDLIHRFITFIDALYDTHGKLILSSEVPVQEIY 398

  Fly   397 SFTGGSKTLSDSERTLMDDLNIKESKASFFTGEEELFAFDRTLSRLYEMQKREY 450
            . |..|:.||.:....... .|:......|.|.||:|.|.|.||||.||:|:.:
pombe   399 P-TAPSEVLSSTADPAAKG-KIESHYHGAFGGIEEVFTFTRCLSRLSEMKKQSW 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8520	NP_001188911.1	YhcM	22..450	CDD:224402	153/442 (35%)
CG8520	NP_001188911.1	P-loop_NTPase	31..450	CDD:304359	153/442 (35%)
SPBC115.02c	NP_595259.1	YhcM	29..454	CDD:224402	153/444 (34%)
SPBC115.02c	NP_595259.1	P-loop_NTPase	35..450	CDD:304359	153/442 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	219	1.000	Domainoid score	I556
eggNOG	1	0.900	-	-		E1_COG1485
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5782
Inparanoid	1	1.050	238	1.000	Inparanoid score	I825
OMA	1	1.010	-	-		QHG54198
OrthoFinder	1	1.000	-	-		FOG0003120
OrthoInspector	1	1.000	-	-		oto100439
orthoMCL	1	0.900	-	-		OOG6_101377
Panther	1	1.100	-	-	LDO	PTHR12169
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4204
SonicParanoid	1	1.000	-	-		X2090
TreeFam	1	0.960	-	-
	13	12.950