DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8520 and AFG1L

DIOPT Version :9

Sequence 1:	NP_001188911.1	Gene:	CG8520 / 36357	FlyBaseID:	FBgn0033734	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_660358.2	Gene:	AFG1L / 246269	HGNCID:	16411	Length:	481	Species:	Homo sapiens

Alignment Length:	439	Identity:	195/439 - (44%)
Similarity:	268/439 - (61%)	Gaps:	45/439 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CHMSGLSPLKEYEKRVSSGQLMTDNRQLQTMKELDALYHKIQGYKPSYRAGGGGGGFFSSIFGRK 89
            ||    .||..|:..:.:.:|..|..|.:.::.|..|:..::||...      ..|.||.:|.|
Human    72 CH----GPLDHYDFLIKAHELKDDEHQRRVIQCLQKLHEDLKGYNIE------AEGLFSKLFSR- 125

  Fly    90 SSTEDDDQDDPNAGSHAPQGLYLYGSVGVGKTTLMDLFFDCCTQIHRKQRVHFTSFMNTVHTRIH 154
                          |..|:|||:||.||.|||.:||:|: ...::.||:||||..||..||.|||
Human   126 --------------SKPPRGLYVYGDVGTGKTMVMDMFY-AYVEMKRKKRVHFHGFMLDVHKRIH 175

  Fly   155 EAKQRQGPVDRAFNSEKPA----PFDPTKPVADLIASESWLICFDEFQVTDIADAMVLKRLFTHL 215
            ..||       :....||.    .:||..|:|:.|:.|:.|:||||||||||||||:||:||.:|
Human   176 RLKQ-------SLPKRKPGFMAKSYDPIAPIAEEISEEACLLCFDEFQVTDIADAMILKQLFENL 233

  Fly   216 FRHGIVVVATSNRHPEDLYKNGLQRTNFLPFIALLQRRCKVSQLDS-IDYRR--IAQSGDTNYFV 277
            |::|:||||||||.|||||||||||.||:||||:|:..|...|||| ||||:  :..:|.. |::
Human   234 FKNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCNTVQLDSGIDYRKRELPAAGKL-YYL 297

  Fly   278 KGQTDADGSMNRMFKILCAEENDIIRPRTLTHFGRDLTFNRTCGQVLDSTFSELCDRPLAGSDFL 342
            ..:.|.:..|:::|..|..::||:.|||.|...||:|..|:.||.|.|.||.|||:|||..||:|
Human   298 TSEADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRLNKACGTVADCTFEELCERPLGASDYL 362

  Fly   343 QISQFFHTVLIRDVPQLTLDVKAQMRRFITLIDTLYNNRVRVVISSDVALENLFSFTGGSKTLSD 407
            ::|:.|.|:.:|::||.||..:.|.||||||||..|:.:||::.|:...:.:||........|..
Human   363 ELSKNFDTIFLRNIPQFTLANRTQGRRFITLIDNFYDLKVRIICSASTPISSLFLHQHHDSELEQ 427

  Fly   408 SERTLMDDLNIKESKA---SFFTGEEELFAFDRTLSRLYEMQKREYWEQ 453
            | |.|||||.:.:..|   |.||||||:|||.||:|||.|||..:||.:
Human   428 S-RILMDDLGLSQDSAEGLSMFTGEEEIFAFQRTISRLTEMQTEQYWNE 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8520	NP_001188911.1	YhcM	22..450	CDD:224402	193/434 (44%)
CG8520	NP_001188911.1	P-loop_NTPase	31..450	CDD:304359	191/428 (45%)
AFG1L	NP_660358.2	YhcM	73..472	CDD:224402	192/433 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160197
Domainoid	1	1.000	301	1.000	Domainoid score	I1417
eggNOG	1	0.900	-	-		E1_COG1485
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5782
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2264
Isobase	1	0.950	-	0	Normalized mean entropy	S1327
OMA	1	1.010	-	-		QHG54198
OrthoDB	1	1.010	-	-		D263573at33208
OrthoFinder	1	1.000	-	-		FOG0003120
OrthoInspector	1	1.000	-	-		oto88374
orthoMCL	1	0.900	-	-		OOG6_101377
Panther	1	1.100	-	-	LDO	PTHR12169
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4204
SonicParanoid	1	1.000	-	-		X2090
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.840