DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8520 and Afg1l

DIOPT Version :9

Sequence 1:	NP_001188911.1	Gene:	CG8520 / 36357	FlyBaseID:	FBgn0033734	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_665686.2	Gene:	Afg1l / 215951	MGIID:	2148801	Length:	480	Species:	Mus musculus

Alignment Length:	451	Identity:	199/451 - (44%)
Similarity:	276/451 - (61%)	Gaps:	40/451 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ARQKPLLLWAPACHMSGLSPLKEYEKRVSSGQLMTDNRQLQTMKELDALYHKIQGYKPSYRAGGG 77
            ||.|.|.:    ||    .||..|:..:.|.:|..|..|.:.::.|..|...::||...
Mouse    64 ARLKALAV----CH----GPLDHYDFLIKSQELREDEHQRRVVQCLQKLQEDLKGYSIE------ 114

  Fly    78 GGGFFSSIFGRKSSTEDDDQDDPNAGSHAPQGLYLYGSVGVGKTTLMDLFFDCCTQIHRKQRVHF 142
            .||.||.:|.|               :..|:|||:||.||.|||.:||:|: ...:..||:||||
Mouse   115 EGGLFSKLFSR---------------NKPPKGLYVYGDVGTGKTMVMDMFY-AYVETKRKKRVHF 163

  Fly   143 TSFMNTVHTRIHEAKQRQGPVDRAFNSEKPAPFDPTKPVADLIASESWLICFDEFQVTDIADAMV 207
            ..||..||.|||..||........|.::.   :||..|:|:.|:.|:.|:||||||||||||||:
Mouse   164 HGFMLDVHRRIHHLKQSLPKRKAGFMAKS---YDPIAPIAEEISQETSLLCFDEFQVTDIADAMI 225

  Fly   208 LKRLFTHLFRHGIVVVATSNRHPEDLYKNGLQRTNFLPFIALLQRRCKVSQLDS-IDYRR--IAQ 269
            ||:||.:||::|:||||||||.|||||||||||.||:||||:|:..|...|||| :|||:  :|.
Mouse   226 LKQLFENLFKNGVVVVATSNRPPEDLYKNGLQRANFVPFIAVLKEYCDTLQLDSGVDYRKRELAP 290

  Fly   270 SGDTNYFVKGQTDADGSMNRMFKILCAEENDIIRPRTLTHFGRDLTFNRTCGQVLDSTFSELCDR 334
            :|.. |::..:.|.:..::::|..|..::||:..||.|...||:|..|:.||.|.|.||.|||:|
Mouse   291 AGKL-YYLTSEADVEAVVDKLFDELAQKQNDLTSPRILKVQGRELRLNKACGSVADCTFEELCER 354

  Fly   335 PLAGSDFLQISQFFHTVLIRDVPQLTLDVKAQMRRFITLIDTLYNNRVRVVISSDVALENLFSFT 399
            ||..||:|::|:.|.||:||::||.:|..:.|.||||||||..|:.:||::.|:...:.:|| ..
Mouse   355 PLGASDYLELSKNFDTVIIRNIPQFSLAKRTQARRFITLIDNFYDFKVRIICSASAPISSLF-LH 418

  Fly   400 GGSKTLSDSERTLMDDLNIKESKA--SFFTGEEELFAFDRTLSRLYEMQKREYWEQWAKHR 458
            ....:.||..|.|||||.:.:..|  |.||||||:|||.||:|||.|||..:||.:..:.|
Mouse   419 QHQDSESDQSRILMDDLGLSQDSAGLSMFTGEEEIFAFQRTISRLTEMQTEQYWIEGDRSR 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8520	NP_001188911.1	YhcM	22..450	CDD:224402	192/432 (44%)
CG8520	NP_001188911.1	P-loop_NTPase	31..450	CDD:304359	190/423 (45%)
Afg1l	NP_665686.2	YhcM	73..471	CDD:224402	191/428 (45%)
Afg1l	NP_665686.2	P-loop_NTPase	75..471	CDD:304359	190/422 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850571
Domainoid	1	1.000	300	1.000	Domainoid score	I1428
eggNOG	1	0.900	-	-		E1_COG1485
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5782
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2251
Isobase	1	0.950	-	0	Normalized mean entropy	S1327
OMA	1	1.010	-	-		QHG54198
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003120
OrthoInspector	1	1.000	-	-		oto91945
orthoMCL	1	0.900	-	-		OOG6_101377
Panther	1	1.100	-	-	LDO	PTHR12169
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2090
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.800