DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8834 and Acsf2

DIOPT Version :9

Sequence 1:	NP_610779.1	Gene:	CG8834 / 36356	FlyBaseID:	FBgn0033733	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001030123.1	Gene:	Acsf2 / 619561	RGDID:	1562656	Length:	615	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	140/570 - (24%)
Similarity:	226/570 - (39%)	Gaps:	108/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SVGKIIFNNMKNWPKNVCQICDVDGVTVTFEQGLTWSIRIAQYLKKRGLNHKDVIGIAAKNSTYV 93
            :||:.:....:.:|.....:...:.:.:.|.|......|.|..|...||...|.:|:...||...
  Rat    73 TVGECLDATAQRFPNREALVIIHENIRLNFAQLKEEVDRAASGLLSIGLRKGDRLGMWGPNSYAW 137

  Fly    94 MPLGVACLMNGTPFHSVNPVLDDATLTHVFSITKPTLIFCDG---------QEYDKVHKATVGWH 149
            :.:.:|....|....||||....:.|.:|.     ..:.|.|         |:|..:.|...
  Rat   138 VLIQLATAQAGIILVSVNPAYQASELEYVL-----RKVGCKGIVFPKQFKTQQYYNILKQVC--- 194

  Fly   150 PEILTLTDHVEGVQGIETLLDPTTTEKIYQP--------EVLKEGG-DQTVAIL--------C-- 195
            ||   |.....|....|.|.|.||...:..|        ||:..|| :|.:|.|        |
  Rat   195 PE---LEKAQPGALKSERLPDLTTVISVDAPLPGTLLLDEVVAAGGKEQNLAQLRYHQGFLSCYD 256

  Fly   196 ------SSGTTGLPKAVCISNSILIQDSMLI---------TSQSV-------IYVGSCLDWITGL 238
                  :|||||.||...:|:..::.:|.||         |::.:       :|  .||..:.|.
  Rat   257 PINIQFTSGTTGNPKGATLSHHNIVNNSNLIGQRLKMPAKTAEELRMVLPCPLY--HCLGSVGGT 319

  Fly   239 WAFVFSTVFGCTRIISNKAFTPEYFVGLVKKYKINYAVLPPRHLSALITCPDAKPDALAPITHLN 303
               :.|.|.|.|.::|:.:|..:..:..:.:.|.......|.....::..||........|.
  Rat   320 ---MVSVVHGATLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTTIR--- 378

  Fly   304 YGG---GSISLATLQRS-------QELCKTAMFNSGYGMTEVGAIT-INIGISNV----SSAGRP 353
             ||   ||::...|.|:       :||...      ||.||...:| :|.....:    .|.||.
  Rat   379 -GGVIAGSLAPPELIRAIISKMNMKELVVV------YGTTENSPVTFMNFPEDTLEQKAGSVGRI 436

  Fly   354 VPGIKIRIVD-EDGKSLGYNQVGEIYVHTGQAWNGYYGNPVETRRMQDFEGWFHTGDLGYFDEQN 417
            :|..:.:||: |.|:....|..||:.:.......||:|.|.:|......:.|:.|||:...|||.
  Rat   437 MPHTEAQIVNMETGELTKLNMPGELCIRGYCVMQGYWGEPQKTFETVGQDRWYRTGDIASMDEQG 501

  Fly   418 FLYIVDRKKEILKYNGLHYWPTEIETVIAELSQVQDVCVVGIYDEREGDAAGALVVKSKGATISA 482
            |..||.|.|:::...|.:.:|.|:|....:..|||:..|||:.|:|.|:...|.:....|.|.:.
  Rat   502 FCRIVGRSKDMIIRGGENIYPAELEDFFHKHPQVQEAQVVGVKDDRMGEEICACIRLKSGETTTE 566

  Fly   483 KEI-------VEHVAKRLPATQKQLRAGVQFTDKLPANVNGKTMRKTARD 525
            :||       :.|.  ::|..       :.|.:..|..|:||..:...|:
  Rat   567 EEIKAFCKGKISHF--KIPRY-------IVFVEGYPLTVSGKIQKFKLRE 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8834	NP_610779.1	CaiC	20..529	CDD:223395	140/570 (25%)
CG8834	NP_610779.1	AFD_class_I	46..519	CDD:302604	136/545 (25%)
Acsf2	NP_001030123.1	PRK08315	57..615	CDD:236236	140/570 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386992at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920