DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8834 and CG18586

DIOPT Version :9

Sequence 1:	NP_610779.1	Gene:	CG8834 / 36356	FlyBaseID:	FBgn0033733	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	208/526 - (39%)
Similarity:	317/526 - (60%)	Gaps:	6/526 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TYNEKDNIWSGAKRNSIYNYDTSVGKIIFNNMKNWPKNVCQICDVDGVTVTFEQGLTWSIRIAQY 71
            ||::|..||||.:..|:::.:.|:|:|||.:|.|.||.:.||...:.:.:|.|.....::|:|.|
  Fly    16 TYDDKLKIWSGREAPSLFSPNLSIGEIIFGDMVNNPKLIAQISITEDIVLTREDLHMNAMRVASY 80

  Fly    72 LKKRGLNHKDVIGIAAKNSTYVMPLGVACLMNGTPFHSVNPVLDDATLTHVFSITKPTLIFCDGQ 136
            ::..||...|::|:..:::|:...:..||..||||.|:::...::|.:..:|.||||.||||||.
  Fly    81 MRNMGLGQTDIVGVMGRHTTHQSAVAYACFFNGTPLHALHNAYEEACIAKLFGITKPRLIFCDGD 145

  Fly   137 EYDKVHKATVGWHPEILTLTDHVEGVQGIETLLDPTTTEKIYQPEVLKEGGDQTVAILCSSGTTG 201
            ||:||..||......|:|:.:|..|...|:.:| .|...:.:||..||:|.|.|:|||.||||:|
  Fly   146 EYEKVKSATKDLQVTIVTMRNHPRGSVRIQDVL-TTPVMQNFQPLRLKDGIDHTLAILSSSGTSG 209

  Fly   202 LPKAVCISNS-ILIQDSMLITSQSVIYVGSCLDWITGLWAFVFSTVFGCTRIISNKAFTPEYFVG 265
            .||||.|||| .:|.|.|.|.:.::.|..|.|||.:||...:.|.||..|.||::..|.|..|..
  Fly   210 FPKAVTISNSHKIIVDYMAINNSNIQYTSSTLDWCSGLSMAITSGVFSTTSIIADCDFDPGLFCR 274

  Fly   266 LVKKYKINYAVLPPRHLSALITCPDAKPDALAPITHLNYGGGSISLATLQRSQELCKTAMFNSGY 330
            .:.||:|:..:|...:|:....||:.:...|:.:.::.:||.|.||...::.:........|..|
  Fly   275 AIGKYRISMVLLSSSYLAIFANCPEFESADLSSLNYVIFGGSSCSLEVQRKVRSRLSHDCLNFCY 339

  Fly   331 GMTEV---GAITINIGISNVSSAGRPVPGIKIRIVDEDGKSLGYNQVGEIYVHTGQAWNGYYGNP 392
            |:||:   |::.:|.. ...:|.||.:.||||:::||.|::...|.||||..|..|.|.|||.||
  Fly   340 GLTELNSAGSVNLNFD-EKPNSVGRAIRGIKIKVIDEQGEAQEPNVVGEICFHNSQKWAGYYKNP 403

  Fly   393 VETRRMQDFEGWFHTGDLGYFDEQNFLYIVDRKKEILKYNGLHYWPTEIETVIAELSQVQDVCVV 457
            .|||::||.|.|.|||||||.|:..:|:::||.|::|||..:.|:|:|||.||||:..|.:.||.
  Fly   404 DETRQIQDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIAEMPNVLEACVF 468

  Fly   458 GIYDEREGDAAGALVVKSKGATISAKEIVEHVAKRLPATQKQLRAGVQFTDKLPANVNGKTMRKT 522
            ||:|...||.|.|.:||..|..:.|:::||:|.||:.|..|||..|....|::..:.|.||.|..
  Fly   469 GIWDPVNGDEAAASLVKKPGTQLEAQDVVEYVRKRITAKFKQLNGGALIVDQIVRSGNRKTNRSA 533

  Fly   523 ARDVFV 528
            .::.|:
  Fly   534 VKEHFL 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8834	NP_610779.1	CaiC	20..529	CDD:223395	201/513 (39%)
CG8834	NP_610779.1	AFD_class_I	46..519	CDD:302604	188/476 (39%)
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	200/507 (39%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	188/476 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471322
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	9	8.960