DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8834 and CG5568

DIOPT Version :9

Sequence 1:	NP_610779.1	Gene:	CG8834 / 36356	FlyBaseID:	FBgn0033733	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_647992.1	Gene:	CG5568 / 38658	FlyBaseID:	FBgn0035641	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	214/533 - (40%)
Similarity:	317/533 - (59%)	Gaps:	8/533 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TYNEKDNIWSGAKRNSIYNYDTSVGKIIFNNMKNWPKNVCQICDVDGVTVTFEQGLTWSIRIAQY 71
            |::|...||||.::.|:::.|.|:|:|||..|:.......||...:...:|::...|.::::|.|
  Fly    16 TFDENLKIWSGGEKRSLFSPDLSIGEIIFQQMERNAMLTAQISVTENTELTWKDIQTNAMKVASY 80

  Fly    72 LKKRGLNHKDVIGIAAKNSTYVMPLGVACLMNGTPFHSVNPVLDDATLTHVFSITKPTLIFCDGQ 136
            ::|.||...|.:|:..:.:|::..|..||..||||:|:::...:.:.:..:|.||||.||||||.
  Fly    81 MRKLGLEQGDFVGVIGRLTTHLTALAYACFFNGTPYHALHTEYEQSAIERLFGITKPRLIFCDGD 145

  Fly   137 EYDKVHKATVGWHPEILTLTDHVEGVQGIETLLDPTTTEKIYQPEVLKEGGDQTVAILCSSGTTG 201
            |::||..||.|...:|:|:.:|..|:..|:.:| .|..|..::|..||:|.||.:|||.||||:|
  Fly   146 EFEKVQAATKGLQVQIVTMRNHPAGILRIQDIL-TTPVEMNFRPVRLKDGTDQLLAILSSSGTSG 209

  Fly   202 LPKAVCISNSILIQDSMLITSQSVI-YVGSCLDWITGLWAFVFSTVFGCTRIISNKAFTPEYFVG 265
            |||||.||||..|..|.|....|:| |..:.|||.:|:...:.:.||..|.||.:..|.|....|
  Fly   210 LPKAVTISNSHQIIGSFLPVDSSIIQYNPNTLDWASGITMTINAAVFSLTSIIEDCDFDPANLCG 274

  Fly   266 LVKKYKINYAVLPPRHLSALITCPDAKPDALAPITHLNYGGGSISLATLQRSQELCKTAMFNSGY 330
            |::||:|:...:....|:.|..||:.....|:.:.:..|||.:.||....:.:........|..|
  Fly   275 LIEKYRISMVFVSSSQLAMLSNCPEFYAADLSSVKYFFYGGSNCSLEVQNKIRSRLSNECVNFSY 339

  Fly   331 GMTEV---GAITINIGISNVSSAGRPVPGIKIRIVDEDGKSLGYNQVGEIYVHTGQAWNGYYGNP 392
            .:||:   |.:..|.. ...:|.||||.||:|:||:|.|::.|.|.||||..:.||.|.|||.||
  Fly   340 TLTELNSPGCLNFNFD-EKPNSVGRPVRGIQIKIVNELGEAQGPNVVGEICFNNGQKWPGYYKNP 403

  Fly   393 VETRRMQDFEGWFHTGDLGYFDEQNFLYIVDRKKEILKYNGLHYWPTEIETVIAELSQVQDVCVV 457
            .||::|||.|.|||||||||.||..:|:|:||.|::|||..:.|:|:|||:||||:..|.:.||.
  Fly   404 EETKKMQDSENWFHTGDLGYMDEDGYLFIIDRLKDMLKYQTIMYYPSEIESVIAEMPNVVEACVF 468

  Fly   458 GIYDEREGDAAGALVVKSKGATISAKEIVEHVAKRLPATQKQLRAGVQFTDKLPANVNGKTMRKT 522
            ||:|...||.|.|.|||.:|..:.|:::||:|.||:||..|||..|....|.:..:.|.|..|..
  Fly   469 GIWDPVYGDKAAASVVKKQGTQLEAQDVVEYVRKRIPAKFKQLNGGALIVDHIIQSGNRKANRAA 533

  Fly   523 ARDVFVALRVSGK 535
            .:..|  ||:..|
  Fly   534 TKAEF--LRIMEK 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8834	NP_610779.1	CaiC	20..529	CDD:223395	205/512 (40%)
CG8834	NP_610779.1	AFD_class_I	46..519	CDD:302604	195/476 (41%)
CG5568	NP_647992.1	CaiC	35..540	CDD:223395	204/508 (40%)
CG5568	NP_647992.1	Firefly_Luc_like	55..530	CDD:213279	195/476 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471320
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	9	8.960