DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8834 and CG17999

DIOPT Version :9

Sequence 1:	NP_610779.1	Gene:	CG8834 / 36356	FlyBaseID:	FBgn0033733	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_611517.1	Gene:	CG17999 / 37357	FlyBaseID:	FBgn0034552	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	180/537 - (33%)
Similarity:	274/537 - (51%)	Gaps:	35/537 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 YNEKDNIWSGAKRNSIYNYDTSVGKIIFNNMKNWPKNVCQICDVDGVTVTFEQGLTWSIRIAQYL 72
            |:.....|.|.:....|..:.::|::|...::.....|.||||..|..:|..|....|.||||..
  Fly     7 YDAASRTWFGPRGKDFYGPEMTLGEVIMRVLQINADQVMQICDTTGQELTGAQLAQQSARIAQAF 71

  Fly    73 KKRGLNHKDVIGIAAKNSTYVMPLGVACLMNGTPFHSVNPVLDDATLTHVFSITKPTLIFCDGQE 137
            |:.||...||:||:|.||||:..:.:|.|:.|.|.:.::|...:.|:.:::.||:|.:||||.:.
  Fly    72 KRLGLRRGDVVGISANNSTYLTSVIIAALLRGIPINPLHPEFTEETVKYMYDITEPKVIFCDVEN 136

  Fly   138 YDKVHKATVG--WHP-EILTLTDHVEGVQGIETLL--DPTTTEKIYQPEVLKEGGDQTVAILCSS 197
            | .:.|...|  .:| :|..:...:|||..|..:|  :.:.|...|.| ..|..||.|..|:|||
  Fly   137 Y-HIIKTVNGKLQNPAKIYLVNGKLEGVLDISEMLNDEDSITAAAYVP-CPKLHGDHTAFIVCSS 199

  Fly   198 GTTGLPKAVCISNSILI---QDSMLITSQSVIYVGSCLDWITGLWAFVFSTVFGCTRIISNKAFT 259
            ||||:||.|..|:..|:   ::....|..||:...|.|.||:|....:.|.:.||.|||:|:.::
  Fly   200 GTTGMPKGVTRSHRSLLCNCKNPNTYTRDSVLLSFSPLYWISGTIILLASLLNGCRRIITNRPYS 264

  Fly   260 PEYFVGLVKKYKINYAVLPPRHLSALITCPDAKPDA--------LAPITHLNYGGGSISLATLQR 316
            .||.:.||.::|:.:..|....::.|     :|.|:        |..|..|...|..:..|..:|
  Fly   265 VEYLLQLVARHKVTFLFLASHQIALL-----SKHDSDVMELKAQLQSIRVLIGAGSKVCKAVCRR 324

  Fly   317 SQELCKTAMFNSGYGMTEVGAITINIGISNVSSAGRPVPGIKIRIVDEDGKSLGYNQVGEIYVHT 381
            ..||.....|..|||::|:|.::.|:| ..|...|:.:..:::|::|:....||.|:||.||...
  Fly   325 MYELIGNQRFVVGYGLSEMGGLSKNVG-GPVGCEGKVMRNVELRVLDKLKMPLGINEVGIIYARL 388

  Fly   382 GQAWNGYYGNPVETRRMQDFEG-WFHTGDLGYFDEQNFLYIVDRKKEILKYNGLHYWPTEIETVI 445
            ...|.|||.||..|||....:| ||.|||:||.|.:.:|||..|..::.|:|....:|.:||..|
  Fly   389 RFKWAGYYRNPEATRRALSSDGMWFRTGDIGYLDSEGYLYIQTRDTDVFKFNNFQIYPEQIEEFI 453

  Fly   446 AELSQVQDVCVVGIYDEREGDAAGALVVKSK---GATISA---KEIVEHVAKRLPATQKQLRAGV 504
            ..|..|.:.||.||.|....:.....||::|   |..::|   :.||||   .|.... .:|.||
  Fly   454 LRLPGVSEACVFGIPDAVSTNLTACAVVRTKSPEGERLTADHIRNIVEH---HLSGAY-HIRGGV 514

  Fly   505 QFTDKLPANVNGKTMRK 521
            .|.|.||...|.|..|:
  Fly   515 YFIDSLPKTPNDKLQRR 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8834	NP_610779.1	CaiC	20..529	CDD:223395	177/525 (34%)
CG8834	NP_610779.1	AFD_class_I	46..519	CDD:302604	172/495 (35%)
CG17999	NP_611517.1	CaiC	25..545	CDD:223395	176/519 (34%)
CG17999	NP_611517.1	AFD_class_I	38..529	CDD:302604	173/502 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471343
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	7	6.960