DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8834 and acs-2

DIOPT Version :9

Sequence 1:	NP_610779.1	Gene:	CG8834 / 36356	FlyBaseID:	FBgn0033733	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_506869.1	Gene:	acs-2 / 3565680	WormBaseID:	WBGene00009221	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	118/577 - (20%)
Similarity:	215/577 - (37%)	Gaps:	82/577 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PTTYNEKDNIWSGAKRNSIYNYDTSVGKIIFNNMKNWP-KNVCQICDVDGVTVTFEQGLTWSIRI 68
            |:.:.:..|.:.....|.....:| :|:.:.|..:..| |..| :.....:..|:|:......::
Worm    37 PSVHRQHTNSYIHGTSNIPLRNET-LGQTLRNTTERVPDKEFC-VFSKYPIRKTYEEFYHDVRQM 99

  Fly    69 AQYLKKRGLNHKDVIGIAAKNSTYVMPLGVACLMNGTPFHSVNPVLDDATLTHVFSITKPTLIFC 133
            |..|...||...|.:|:...|....:.|..||...|....:|||......|..|...|...::|.
Worm   100 AASLYTLGLEKGDRVGVWGPNYYEWVVLQYACAFAGVIQVNVNPHYLHEELRFVMRKTGMKVLFA 164

  Fly   134 DGQEYDKVHKATVGWHPEILTLTDHVEGVQGIETLLDPTTTE----KIYQPEVLKEGG------- 187
                 .|.||.:...|..:..:.:...|..|:..:......|    .:|..:|...|.
Worm   165 -----PKRHKHSNYVHTMLEAMPEMRRGQPGVGHIKSHDIPELRHIVLYGDDVPVHGAWVYSDLI 224

  Fly   188 --------------------DQTVAILCSSGTTGLPKAVCISNSILIQDSMLITSQSVIYVGSCL 232
                                |:.|.:..:|||||.||...:::..|        :.:..:.|..|
Worm   225 HAAGSAERAKLEDMDRKLRPDEPVNMQFTSGTTGHPKGATLTHFGL--------NNNAYFAGIRL 281

  Fly   233 DW---------------ITGLWAFVFSTV-FGCTRIISNKAF-TPEYFVGLVKKYKINYAVLPPR 280
            .|               ..|....|.:.| .|.|.:..:|:: .|:.|.. ::..|.......|.
Worm   282 GWDREDHRICIPNPLYHCFGCAVGVINAVNHGQTVVFPSKSYHVPDIFEA-IQNEKCTTMFGTPT 345

  Fly   281 HLSALITCPDAKPDALAPITHLNYGGGSISLATLQRSQELCKTAMFNSGYGMTEVGAIT----IN 341
            ....::..|..|...::.:.....||....:|..::..:..:...|:..||.||...:.    ::
Worm   346 MFIDVLKSPLMKQFDISSLRGGVIGGAPCPMALCEKMVKEMRMTDFSVIYGSTETSPLVTMSELH 410

  Fly   342 IG-ISNVSSAGRPVPGIKIRIVDEDGKSLGYNQVGEIYVHTGQAWNGYYGNPVETRRMQDFEGWF 405
            :. ...:.|.|..:|..::.||||.|..:.....||::........||:.:..:|......:.|:
Worm   411 VDPFERIKSVGSVMPHQELAIVDEFGVPVPTGAKGELWSRGYSTMLGYWADHDKTNLAITRDRWY 475

  Fly   406 HTGDLGYFDEQNFLYIVDRKKEILKYNGLHYWPTEIETVIAELSQVQDVCVVGIYDEREGDAAGA 470
            .:||....:|...:.||.|.::::...|.:.:|||||..:.:|..|.|..|||:.|:|.|:...|
Worm   476 KSGDTATMNEDGTINIVGRTRDMIVKGGENVYPTEIEQFLHKLDYVADAHVVGVPDDRYGENICA 540

  Fly   471 LV---VKSKGATISAKEIVEHVAKRLPATQKQLRAG----VQFTDKLPANVNGKTMR 520
            .|   |:.:|     |...||:.|.........:..    ::...:.|..::||..:
Worm   541 WVRLRVEDEG-----KITAEHIKKACKRGMAHYKVPKYVLIKKESEFPLTISGKVKK 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8834	NP_610779.1	CaiC	20..529	CDD:223395	116/562 (21%)
CG8834	NP_610779.1	AFD_class_I	46..519	CDD:302604	110/532 (21%)
acs-2	NP_506869.1	PRK08315	46..609	CDD:236236	116/568 (20%)
acs-2	NP_506869.1	FACL_like_2	244..595	CDD:213284	79/363 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386992at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920