Protein Alignment INPP5D and Inpp5d

DIOPT Version :10

• Sequence 1: NP_001017915.1
• Gene: INPP5D / 3635
• HGNCID: 6079
• Length: 1189
• Species: Homo sapiens
• Sequence 2: NP_062184.2
• Gene: Inpp5d / 54259
• RGDID: 2914
• Length: 1190
• Species: Rattus norvegicus
• Alignment Length: 1195
• Identity: 1046/1195 - (87%)
• Similarity: 1096/1195 - (91%)
• Gaps: 14/1195 - (1%)

Human     1 MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTV 65
            |||.|||||||||||||||||.||||||||||||||.||||||||:|||||||||||||||||||
  Rat     4 MVPGWNHGNITRSKAEELLSRAGKDGSFLVRASESIPRAYALCVLFRNCVYTYRILPNEDDKFTV 68

Human    66 QASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESVVSPPELPPRN 130
            ||||||.||||||||||||||||||||||||||:||||||||..|:||||| |||:|||||||||
  Rat    69 QASEGVPMRFFTKLDQLIEFYKKENMGLVTHLQFPVPLEEEDAIDEPEEDT-ESVMSPPELPPRN 132

Human   131 IPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLAQD 195
            ||::|..||||::|...|||||.|.:|.||||||||||||||||||||||||||||||||||..|
  Rat   133 IPVSAGPCEAKDLPLPTENPRAPEVTRLSLSETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLMLD 197

Human   196 SEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQQLSPGLRPRPQVPGEANPIN 260
            |:|:|||||:||||||||:||||||:||||||||||||||||||||||||||||||||||||||.
  Rat   198 SDFLKTGSSNLPHLKKLTSLLCKELHGEVIRTLPSLESLQRLFDQQLSPGLRPRPQVPGEANPIT 262

Human   261 MVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKL 325
            ||:|||||||||||||||||||||||.||.:|.|||||||||||:|||||||||.||||||||||
  Rat   263 MVAKLSQLTSLLSSIEDKVKALLHEGSESTNRRSLIPPVTFEVKSESLGIPQKMHLKVDVESGKL 327

Human   326 IIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQ 390
            |||||:||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
  Rat   328 IIKKSRDGSEDKFYSHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFSDSKKREGFCQLLQQ 392

Human   391 MKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDP 455
            ||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   393 MKNKHSEQSEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDP 457

Human   456 LSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGN 520
            |.||||||||:|||||:||:|||||||||||||||||||||||||||||||||||||||||||||
  Rat   458 LGEKEWLEILRHSLQEVTSMTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGN 522

Human   521 KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWF 585
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.
  Rat   523 KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWL 587

Human   586 GDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLT 650
            |||||||:|||||||.||||||||||:|||:|||||.||:|||||||||||||||||||||||||
  Rat   588 GDLNYRVELPTWEAEAIIQKIKQQQYSDLLAHDQLLLERKEQKVFLHFEEEEITFAPTYRFERLT 652

Human   651 RDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQ 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   653 RDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQ 717

Human   716 FVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGELVVKF 780
            ||||||||.||||||||||.||||||||||||||||.|||||||||||||||||||.||||||:|
  Rat   718 FVSKNGPGAVDSQGQIEFLACYATLKTKSQTKFYLELHSSCLESFVKSQEGENEEGDEGELVVRF 782

Human   781 GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHHGELTG 845
            |||||||||||||||||||||||||||||||||||||||||||||.||:|||||||||||||:||
  Rat   783 GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLETTESQLPIYTPLTHHGEMTG 847

Human   846 HFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEI 910
            ||:||||||||:||.|||||||||||||||||.|.||:|||||||:|||...|.|.|..||:.||
  Rat   848 HFRGEIKLQTSEGKMREKLYDFVKTERDESSGMKCLKNLTSHDPMRQWEPAGRVPACGISSLNEI 912

Human   911 INPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPISPKKF 975
            |||||:|:||||  .|||.|.|||||||.|||||||.||||.|||.|||.|||||.|||:|||||
  Rat   913 INPNYIGMGPFG--QPLHGKSTLSPDQQLTAWSYDQLPKDSSLGPGRGEGPPTPPSQPPLSPKKF 975

Human   976 LPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESP 1040
            ..||||||..||.||:||.||||  .:.|||||||||||||||||||||:|.|||..|||:||||
  Rat   976 SSSTANRGSCPRVQETRPGDLGK--VEALPQEDLPLTKPEMFENPLYGSVSPFPKLVPRKEQESP 1038

Human  1041 KMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQV------PAPRLRSFTCSSSAEGRAAGG 1099
            ||.||||||||:||:.||||:|.||||.:..:|..||.      |.||:||||||||||||...|
  Rat  1039 KMMRKEPPPCPDPGVSSPSIMLPKAQEVENVKGTSKQAPVPVFGPTPRIRSFTCSSSAEGRMPSG 1103

Human  1100 DKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDYRDN 1164
            ||||||||.|.|||||||.|||:||||||::|||.|.|.|||||||||||||.||||||||||||
  Rat  1104 DKSQGKPKAPASSQAPVPVKRPVKPSRSEMSQQTTPIPAPRPPLPVKSPAVLQLQHSKGRDYRDN 1168

Human  1165 TELPHHGKHRPEEGPPGPLGRTAMQ 1189
            ||||||||||.||   ..|||||||
  Rat  1169 TELPHHGKHRQEE---SLLGRTAMQ 1190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5D	NP_001017915.1	SH2_SHIP	1..102	CDD:198206	94/100 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..132		23/28 (82%)
		SH3-binding 1	124..129		4/4 (100%)
		INPP5c_SHIP1-INPP5D	404..710	CDD:197334	294/305 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	870..906		24/35 (69%)
		PHA03307	899..>1127	CDD:223039	167/233 (72%)
		NPXY motif 1	912..915		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	922..1189		202/272 (74%)
		SH3-binding 2	969..974		3/4 (75%)
		Interaction with DAB2. /evidence=ECO:0000250	1016..1030		11/13 (85%)
		NPXY motif 2	1019..1022		2/2 (100%)
		SH3-binding 3	1040..1051		9/10 (90%)
Inpp5d	NP_062184.2	SH2_SHIP	4..105	CDD:198206	94/100 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..130		14/19 (74%)
		SH3-binding 1	126..131		4/4 (100%)
		INPP5c_SHIP1-INPP5D	406..712	CDD:197334	294/305 (96%)
		NPXY motif 1	914..917		2/2 (100%)
		PTZ00449	<930..>1132	CDD:185628	149/203 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	946..1190		184/248 (74%)
		SH3-binding 2	969..974		3/4 (75%)
		Interaction with DAB2. /evidence=ECO:0000250	1014..1028		11/13 (85%)
		NPXY motif 2	1017..1020		2/2 (100%)
		SH3-binding 3	1038..1049		9/10 (90%)