DRSC/TRiP Functional Genomics Resources

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Protein Alignment INPP5D and inpp-5K

DIOPT Version :10

Sequence 1:NP_001017915.1 Gene:INPP5D / 3635 HGNCID:6079 Length:1189 Species:Homo sapiens
Sequence 2:NP_498783.1 Gene:inpp-5K / 183643 WormBaseID:WBGene00086546 Length:398 Species:Caenorhabditis elegans


Alignment Length:334 Identity:95/334 - (28%)
Similarity:139/334 - (41%) Gaps:68/334 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   404 ITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEWLEILKHS 468
            ||||  |:|:.......:.....|:   |...|.:      .:..||.||...||.....:|   
 Worm     5 ITIF--TYNLAMKASDSEAVHNMLN---GMIDDHT------HLVAIGLQEVAHSETIGGAVL--- 55

Human   469 LQEITSVTFKTVAIHTLWNIRIVVLAKPEHE----------------NRISHICTDNVKTGIANT 517
                |..|  |:|.....|.|:|:|||....                .||.:....|...|:.  
 Worm    56 ----TWAT--TIASWMNTNGRMVLLAKTFQATNQVLIFGRKQLIGQIKRIDYRFQRNTMGGLT-- 112

Human   518 LGNKGAVGVSF-MFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTH 581
             |:||::||.. :.:..|:.||:||...|.|...:|.:.|..........||.:..         
 Worm   113 -GHKGSIGVRLQLASPYSIVFVDSHFIHGPENYGKRVEQYHTNRNCSFPEDKSVRA--------- 167

Human   582 LFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLL-SHDQLLTERREQKVFLHFEEEEITFAPTYR 645
            .|||||.|:||:   .:..|:|:|||...:.:|| :.:||.....|:..|:.|.|:.:||.||||
 Worm   168 AFWFGDFNFRVE---EDVNTVIRKIKNGTHLELLDTREQLKRALVERDAFIGFHEQPVTFEPTYR 229

Human   646 FERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEA 710
            ....|      |:|...    .:|||.||:|:|...:..:   ||.:....:.|||.||.|.|. 
 Worm   230 VTVGT------TEQDGK----RVPSWTDRILYKGDGITGL---SYTNNKKAVASDHLPVVAMFR- 280

Human   711 GVTSQFVSK 719
             ||:....|
 Worm   281 -VTAPAAPK 288

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INPP5DNP_001017915.1 SH2_SHIP 1..102 CDD:198206
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 103..132
SH3-binding 1 124..129
INPP5c_SHIP1-INPP5D 404..710 CDD:197334 92/323 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 870..906
PHA03307 899..>1127 CDD:223039
NPXY motif 1 912..915
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 922..1189
SH3-binding 2 969..974
Interaction with DAB2. /evidence=ECO:0000250 1016..1030
NPXY motif 2 1019..1022
SH3-binding 3 1040..1051
inpp-5KNP_498783.1 IPPc 1..284 CDD:214525 94/328 (29%)
SKICH 293..394 CDD:465482
Blue background indicates that the domain is not in the aligned region.

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