DRSC/TRiP Functional Genomics Resources

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Protein Alignment INPP5D and sac-2

DIOPT Version :10

Sequence 1:NP_001017915.1 Gene:INPP5D / 3635 HGNCID:6079 Length:1189 Species:Homo sapiens
Sequence 2:NP_001252206.1 Gene:sac-2 / 173236 WormBaseID:WBGene00012353 Length:783 Species:Caenorhabditis elegans


Alignment Length:581 Identity:107/581 - (18%)
Similarity:179/581 - (30%) Gaps:226/581 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   436 DDSADYIPHDIYVIGTQEDPLSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHE- 499
            ::|.:.:..|:.:.|..|..:.:..:.|  :|.|..:  |....||.:.      ...|:..|. 
 Worm    33 EESLEILDQDVVLCGNVEFLIGKISFDE--QHFLFFV--VDSSVVACYR------GTSAESSHSI 87

Human   500 NRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFL- 563
            .||..:...|||        :.|:|             :.|.:|.||..||:  |....|::|. 
 Worm    88 RRIERVIAINVK--------SDGSV-------------IKSQITPGSGTKLK--QGTEKIMKFFA 129

Human   564 ----------ALGDKKLSPFNITHRF--------------------TH-----LFWFGDLNYRVD 593
                      ||.|..|..||.:..|                    .|     .||    |.|:.
 Worm   130 EKVTKAEPRPALLDDVLKLFNDSKDFYFCRSRDVTISSQKYFEKREAHTSEDSFFW----NKRMV 190

Human   594 LPTWEAETIIQKIK---QQQY---ADLLSHDQL-------LTERR-------------------- 625
            ....||: |..|..   .|.|   :.|...||:       :..||                    
 Worm   191 GNLGEAK-ISDKFTCPIMQGYVATSQLEITDQINAYLTITIISRRSTRRAGARYLRRGIDEASNV 254

Human   626 ----EQKVFLHFEEEEITFA------PTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSY 680
                |.::.|:..|.|::|.      |.:..:|              |.||..|.          
 Worm   255 ANFVETELILNIFEHELSFVQCRGSIPVFWSQR--------------GFKYRPPL---------- 295

Human   681 PLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQFVSKNGPGTVDSQGQ-----IEFLRCYATL 740
                ::.:|...|..:.| :|   |...:|...:..|:.:   .||.:|:     ..||......
 Worm   296 ----IINRSVEETHGVFT-EH---FKRLKAHYDTPLVAVS---LVDQRGRELPLAQRFLEHCVKA 349

Human   741 KTKSQTKFYLEFHSSC-------LESFVKSQE--------------GENEEGSEGE--------- 775
            .....|.|..:.|..|       |::.:.|.|              ||..:..:|.         
 Worm   350 DDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCWVDKTGEVVQSQKGVVRTNCIDCL 414

Human   776 -------------LVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEAT 827
                         :|::..:.|....|:...||.|:.....:...:.|...:...|..||:.:  
 Worm   415 DRTNLVQGQISLFVVLQQAQRLGIFGPLCEPPEVLVQTMQTMWADNGDVISTQYAGTAALKGD-- 477

Human   828 ETQLPIYTPLTHHGELTGHFQGEIK----------LQTSQGKTREKLYDFV--KTERDESS 876
                     :|.:||  ....|.:|          |..::...|:|..:.|  :||.||::
 Worm   478 ---------VTRNGE--RKLMGVMKDGYNSASRYYLTHTKDAQRQKAINIVTGQTEADENA 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INPP5DNP_001017915.1 SH2_SHIP 1..102 CDD:198206
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 103..132
SH3-binding 1 124..129
INPP5c_SHIP1-INPP5D 404..710 CDD:197334 67/353 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 870..906 4/7 (57%)
PHA03307 899..>1127 CDD:223039
NPXY motif 1 912..915
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 922..1189
SH3-binding 2 969..974
Interaction with DAB2. /evidence=ECO:0000250 1016..1030
NPXY motif 2 1019..1022
SH3-binding 3 1040..1051
sac-2NP_001252206.1 COG5329 25..520 CDD:227637 103/572 (18%)
hSac2 549..>615 CDD:463592
Blue background indicates that the domain is not in the aligned region.

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