Protein Alignment INPP5D and Inpp5d

DIOPT Version :10

• Sequence 1: NP_001017915.1
• Gene: INPP5D / 3635
• HGNCID: 6079
• Length: 1189
• Species: Homo sapiens
• Sequence 2: XP_006529212.1
• Gene: Inpp5d / 16331
• MGIID: 107357
• Length: 1196
• Species: Mus musculus
• Alignment Length: 1200
• Identity: 1045/1200 - (87%)
• Similarity: 1097/1200 - (91%)
• Gaps: 18/1200 - (1%)

Human     1 MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTV 65
            |||.|||||||||||||||||.||||||||||||||.||||||||:|||||||||||||||||||
Mouse     4 MVPGWNHGNITRSKAEELLSRAGKDGSFLVRASESIPRAYALCVLFRNCVYTYRILPNEDDKFTV 68

Human    66 QASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESVVSPPELPPRN 130
            ||||||.|||||||||||:|||||||||||||||||||||||..|:.||||||||:|||||||||
Mouse    69 QASEGVPMRFFTKLDQLIDFYKKENMGLVTHLQYPVPLEEEDAIDEAEEDTVESVMSPPELPPRN 133

Human   131 IPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLAQD 195
            ||::|...|||::|.:.|||||.|.:|.||||||||||||||||||||||||||||||||||..|
Mouse   134 IPMSAGPSEAKDLPLATENPRAPEVTRLSLSETLFQRLQSMDTSGLPEEHLKAIQDYLSTQLLLD 198

Human   196 SEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQQLSPGLRPRPQVPGEANPIN 260
            |:|:|||||:|||||||.:||||||:|||||||||||||||||||||||||||||||||||:||.
Mouse   199 SDFLKTGSSNLPHLKKLMSLLCKELHGEVIRTLPSLESLQRLFDQQLSPGLRPRPQVPGEASPIT 263

Human   261 MVSKLSQLTSLLSSIEDKVKALLHEGPESPHRPSLIPPVTFEVKAESLGIPQKMQLKVDVESGKL 325
            ||:|||||||||||||||||:|||||.||.:|.|||||||||||:|||||||||.||||||||||
Mouse   264 MVAKLSQLTSLLSSIEDKVKSLLHEGSESTNRRSLIPPVTFEVKSESLGIPQKMHLKVDVESGKL 328

Human   326 IIKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQ 390
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   329 IVKKSKDGSEDKFYSHKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQ 393

Human   391 MKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDP 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   394 MKNKHSEQPEPDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDP 458

Human   456 LSEKEWLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGN 520
            |.||||||:|:|||||:||:|||||||||||||||||||||||||||||||||||||||||||||
Mouse   459 LGEKEWLELLRHSLQEVTSMTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGN 523

Human   521 KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWF 585
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.
Mouse   524 KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWL 588

Human   586 GDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLT 650
            |||||||:|||||||.||||||||||:|||:|||||.||::||||||||||||||||||||||||
Mouse   589 GDLNYRVELPTWEAEAIIQKIKQQQYSDLLAHDQLLLERKDQKVFLHFEEEEITFAPTYRFERLT 653

Human   651 RDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQ 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   654 RDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDHSPVFATFEAGVTSQ 718

Human   716 FVSKN-----GPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGE 775
            |||||     ||||||||||||||.||||||||||||||||||||||||||||||||||||||||
Mouse   719 FVSKNVSHAPGPGTVDSQGQIEFLACYATLKTKSQTKFYLEFHSSCLESFVKSQEGENEEGSEGE 783

Human   776 LVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLEATETQLPIYTPLTHH 840
            |||:||||||||||||||||||||||||||||||||||||||||||||||.||.|.|||||||||
Mouse   784 LVVRFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGCIALRLETTEAQHPIYTPLTHH 848

Human   841 GELTGHFQGEIKLQTSQGKTREKLYDFVKTERDESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGS 905
            ||:||||:|||||||||||.|||||||||||||||||.|.||:|||||||:|||.:.|.|.|..|
Mouse   849 GEMTGHFRGEIKLQTSQGKMREKLYDFVKTERDESSGMKCLKNLTSHDPMRQWEPSGRVPACGVS 913

Human   906 SITEIINPNYMGVGPFGPPMPLHVKQTLSPDQQPTAWSYDQPPKDSPLGPCRGESPPTPPGQPPI 970
            |:.|:|||||:|:||||  .|||.|.|||||||.|||||||.||||.|||.|||.|||||.|||:
Mouse   914 SLNEMINPNYIGMGPFG--QPLHGKSTLSPDQQLTAWSYDQLPKDSSLGPGRGEGPPTPPSQPPL 976

Human   971 SPKKFLPSTANRGLPPRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRK 1035
            |||||..||||||..||.||:||.||||  .:.|.||||.||||||||||||||:|||||..|||
Mouse   977 SPKKFSSSTANRGPCPRVQEARPGDLGK--VEALLQEDLLLTKPEMFENPLYGSVSSFPKLVPRK 1039

Human  1036 DQESPKMPRKEPPPCPEPGILSPSIVLTKAQEADRGEGPGKQV------PAPRLRSFTCSSSAEG 1094
            :||||||.||||||||:|||.||||||.||||.:..:|..||.      |.||:|||||||||||
Mouse  1040 EQESPKMLRKEPPPCPDPGISSPSIVLPKAQEVESVKGTSKQAPVPVLGPTPRIRSFTCSSSAEG 1104

Human  1095 RAAGGDKSQGKPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGR 1159
            |...|||||||||...|||||||.|||:||||||::|||.|.|.|||||||||||||.|||||||
Mouse  1105 RMTSGDKSQGKPKASASSQAPVPVKRPVKPSRSEMSQQTTPIPAPRPPLPVKSPAVLQLQHSKGR 1169

Human  1160 DYRDNTELPHHGKHRPEEGPPGPLGRTAMQ 1189
            |||||||||||||||.||   |.|||||||
Mouse  1170 DYRDNTELPHHGKHRQEE---GLLGRTAMQ 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INPP5D	NP_001017915.1	SH2_SHIP	1..102	CDD:198206	94/100 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..132		23/28 (82%)
		SH3-binding 1	124..129		4/4 (100%)
		INPP5c_SHIP1-INPP5D	404..710	CDD:197334	292/305 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	870..906		24/35 (69%)
		PHA03307	899..>1127	CDD:223039	166/233 (71%)
		NPXY motif 1	912..915		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	922..1189		203/272 (75%)
		SH3-binding 2	969..974		3/4 (75%)
		Interaction with DAB2. /evidence=ECO:0000250	1016..1030		12/13 (92%)
		NPXY motif 2	1019..1022		2/2 (100%)
		SH3-binding 3	1040..1051		9/10 (90%)
Inpp5d	XP_006529212.1	SH2_SHIP	4..105	CDD:198206	94/100 (94%)
		INPP5c_SHIP1-INPP5D	407..713	CDD:197334	292/305 (96%)