Protein Alignment CG13160 and Tfrc

DIOPT Version :10

• Sequence 1: NP_001260918.1
• Gene: CG13160 / 36343
• FlyBaseID: FBgn0033720
• Length: 875
• Species: Drosophila melanogaster
• Sequence 2: NP_073203.1
• Gene: Tfrc / 64678
• RGDID: 70488
• Length: 761
• Species: Rattus norvegicus
• Alignment Length: 233
• Identity: 44/233 - (18%)
• Similarity: 75/233 - (32%)
• Gaps: 67/233 - (28%)

  Fly   165 YLLVNSHYDTKPGSPGAGDDAAMVVVMLEVLRLVA--VSGDPF--LHPIIFLFNGAEEQPMQGSH 225
            |::|.:..|.  ..||....:....::|::.::.:  :|.|.|  ...|||....|      |.:
  Rat   403 YIVVGAQRDA--WGPGVAKSSVGTGLLLKLAQVFSDMISKDGFRPSRSIIFASWTA------GDY 459

  Fly   226 GFITQHRW------AANCKAL--LNLDSAGAGGRDLLFQGGPNHPWLMEHYRNSAPHPFATTTAE 282
            |.:....|      :.:.||.  :|||....|..:......|....||........||
  Rat   460 GAVGATEWLEGYLSSLHLKAFTYINLDKVVLGTSNFKVSASPLLYTLMGKIMQDVKHP------- 517

  Fly   283 EMFEAGIIPSDTDF-----RIFRDFGVVPGLDMAGV--------------YNGFVYHTKFDRYAV 328
              .:...:..|:::     .:..|....|.|..:|:              |.|    ||.|.|.:
  Rat   518 --IDGKYLYRDSNWISKIEELSLDNAAFPFLAYSGIPAVSFCFCEDEDYPYLG----TKLDTYEI 576

  Fly   329 ISLDSLQNSGDNLLALVWSISNAEEMYDTEAHAAGHAV 366
                           |:..:....:|..|.|..||..:
  Rat   577 ---------------LIQKVPQLNQMVRTAAEVAGQFI 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13160	NP_001260918.1	M28_Fxna_like	71..378	CDD:349872	44/233 (19%)
Tfrc	NP_073203.1	Mediates interaction with SH3BP4. /evidence=ECO:0000250|UniProtKB:P02786	1..67
		Endocytosis signal. /evidence=ECO:0000250|UniProtKB:P02786	20..23
		Stop-transfer sequence. /evidence=ECO:0000250|UniProtKB:P02786	58..61
		PA_TfR	201..378	CDD:239043
		M28_TfR	386..611	CDD:349946	44/233 (19%)
		Ligand-binding. /evidence=ECO:0000250	570..761		9/45 (20%)
		TFR_dimer	638..751	CDD:461238
		Cell attachment site, required for binding to transferrin. /evidence=ECO:0000250|UniProtKB:P02786	647..649