DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33012 and APE3

DIOPT Version :9

Sequence 1:	NP_788335.2	Gene:	CG33012 / 36342	FlyBaseID:	FBgn0053012	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_009845.2	Gene:	APE3 / 852589	SGDID:	S000000490	Length:	537	Species:	Saccharomyces cerevisiae

Alignment Length:	237	Identity:	46/237 - (19%)
Similarity:	89/237 - (37%)	Gaps:	36/237 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 QNVVVKLSSKSSNSTSYLLVNSHYDSKPSSVGTGDAELMVVTMLETLRLMATSEETFLHPIVFLF 245
            ||::.  .:|..:..:.:.:.:|.||.....|..|.....:::|...:.:  :.....:.:.|.:
Yeast   294 QNIIA--DTKHGDPDNIVALGAHSDSVEEGPGINDDGSGTISLLNVAKQL--THFKINNKVRFAW 354

  Fly   246 NGAEEQPFHGSHSFISNHRWSANCKALVNLDSAGAGGREILFQGGPNHPWLM-----KQYKKSA- 304
            ..|||:...||:.:..|.....|.|..|.:|..        ....||:.:.:     |:..|.:
Yeast   355 WAAEEEGLLGSNFYAYNLTKEENSKIRVFMDYD--------MMASPNYEYEIYDANNKENPKGSE 411

  Fly   305 --KHPFATTMAEEIFQADLIPSD--TDFRIFRDFGPVP------GLDMAGCYNGFV----YHTKF 355
              |:.:............|:|.|  :|:..|.:.| :|      |.:.....||.|    ||...
Yeast   412 ELKNLYVDYYKAHHLNYTLVPFDGRSDYVGFINNG-IPAGGIATGAEKNNVNNGKVLDRCYHQLC 475

  Fly   356 DRYKVISRGALQNTGDNVLSLVRSISNAEEMY---DTEAHSE 394
            |....:|..|.......:...|.:.:::.|.:   :|:.|.|
Yeast   476 DDVSNLSWDAFITNTKLIAHSVATYADSFEGFPKRETQKHKE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33012	NP_788335.2	M28_Fxna_like	103..410	CDD:193497	46/237 (19%)
APE3	NP_009845.2	M28_SGAP_like	78..506	CDD:349873	42/224 (19%)
APE3	NP_009845.2	PA_ScAPY_like	155..284	CDD:239045
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900