DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33012 and TFRC

DIOPT Version :9

Sequence 1:	NP_788335.2	Gene:	CG33012 / 36342	FlyBaseID:	FBgn0053012	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_001121620.1	Gene:	TFRC / 7037	HGNCID:	11763	Length:	760	Species:	Homo sapiens

Alignment Length:	345	Identity:	68/345 - (19%)
Similarity:	123/345 - (35%)	Gaps:	78/345 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 YPLFNHLPTGVKIEEEANLPG----TFVAQRAESILIRLDLMGPKIAGDYVTEVEMVEFLLGEIS 144
            :|.|||  |.......:.||.    |.....||.:...::...|   .|:.|: .....:..|..
Human   313 FPSFNH--TQFPPSRSSGLPNIPVQTISRAAAEKLFGNMEGDCP---SDWKTD-STCRMVTSESK 371

  Fly   145 KVRDEMRNDLYDMEVDVQRSSGSFLHWQMINMYQGIQNVVVKLSSKSSNSTSYLLVNSHYDSKPS 209
            .|:..:.|.|.::::              :|::..|:..|        ....|::|.:..|
Human   372 NVKLTVSNVLKEIKI--------------LNIFGVIKGFV--------EPDHYVVVGAQRD---- 410

  Fly   210 SVGTGDAELMVVTMLETLRLMATSEETFL-------HPIVFLFNGAEEQPFHGSHSFISNHRWSA 267
            :.|.|.|:..|.|.| .|:|.....:..|       ..|:|....|.:....|:..::..:..|.
Human   411 AWGPGAAKSGVGTAL-LLKLAQMFSDMVLKDGFQPSRSIIFASWSAGDFGSVGATEWLEGYLSSL 474

  Fly   268 NCKAL--VNLDSAGAGGREILFQGGPNHPWLMKQYKKSAKHPFATTMAEEIFQ-------ADLIP 323
            :.||.  :|||.|..|.........|....|:::..::.|||   ...:.::|       .:.:.
Human   475 HLKAFTYINLDKAVLGTSNFKVSASPLLYTLIEKTMQNVKHP---VTGQFLYQDSNWASKVEKLT 536

  Fly   324 SDTDFRIFRDFGPVPGLDMAGC------YNGFVYHTKFDRYK----------VISRGALQNTGDN 372
            .|.....|..:..:|.:....|      |.|    |..|.||          .::|.|.:..|..
Human   537 LDNAAFPFLAYSGIPAVSFCFCEDTDYPYLG----TTMDTYKELIERIPELNKVARAAAEVAGQF 597

  Fly   373 VLSLVRSIS-NAE-EMYDTE 390
            |:.|...:. |.: |.|:::
Human   598 VIKLTHDVELNLDYERYNSQ 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33012	NP_788335.2	M28_Fxna_like	103..410	CDD:193497	62/326 (19%)
TFRC	NP_001121620.1	Mediates interaction with SH3BP4. /evidence=ECO:0000269\|PubMed:16325581	1..67
		Endocytosis signal. /evidence=ECO:0000269\|PubMed:2298808	20..23
		Stop-transfer sequence. /evidence=ECO:0000303\|PubMed:6090955	58..61
		PA_TfR	201..377	CDD:239043	15/69 (22%)
		M28_TfR	385..610	CDD:193572	49/258 (19%)
		Ligand-binding	569..760		11/49 (22%)
		TFR_dimer	642..750	CDD:282153
		Cell attachment site, required for binding to transferrin	646..648
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900