DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33012 and CG9416

DIOPT Version :9

Sequence 1:	NP_788335.2	Gene:	CG33012 / 36342	FlyBaseID:	FBgn0053012	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_001261088.1	Gene:	CG9416 / 37223	FlyBaseID:	FBgn0034438	Length:	861	Species:	Drosophila melanogaster

Alignment Length:	872	Identity:	334/872 - (38%)
Similarity:	529/872 - (60%)	Gaps:	31/872 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 KSRFS--------KQLEWYYSPAYLLFWVGLFFAVCYPLFNHLPTGVKIEEEANLPGTFVAQRAE 112
            ||::.        .::.||::|.::..|..||:.|..|.|:.:|....:|:|...||.|:.:|||
  Fly     2 KSKYENMKIIYNRSKIGWYWAPLFVSCWFLLFYLVVIPSFHRMPQLKTLEDERQQPGQFIGERAE 66

  Fly   113 SILIRLDLMGPKIAGDYVTEVEMVEFLLGEISKVRDEMRNDLYDMEVDVQRSSGSFLHWQMINMY 177
            :.|:||..:|||:.|....|...|:|||.||..:.|:.|.||||:|.|||.:||::|.|.|:|:|
  Fly    67 NTLLRLSKIGPKVVGSAANEQVAVQFLLSEIGDIIDDARTDLYDIEKDVQVASGNYLLWSMVNVY 131

  Fly   178 QGIQNVVVKLSSKSSNSTSYLLVNSHYDSKPSSVGTGDAELMVVTMLETLRLMATSEETFLHPIV 242
            |.|||||||||.|::.|.:.||:|||:||.|.|.|.|||.:|.|.|||.||::...|....:.:|
  Fly   132 QSIQNVVVKLSPKNATSEAALLINSHFDSVPGSSGAGDAGMMCVIMLEVLRVITKYETPLTYSVV 196

  Fly   243 FLFNGAEEQPFHGSHSFISNHRWSANCKALVNLDSAGAGGREILFQGGPNHPWLMKQYKKSAKHP 307
            ||||||||.|..|||:||:.|.|:.|.:|::||||||:||||||||.||:||||||.|.|:..||
  Fly   197 FLFNGAEENPLQGSHAFITQHPWAQNIRAVINLDSAGSGGREILFQSGPDHPWLMKYYGKNIVHP 261

  Fly   308 FATTMAEEIFQADLIPSDTDFRIFRDFGPVPGLDMAGCYNGFVYHTKFDRYKVISRGALQNTGDN 372
            ||:|:.||:||...:||:||:|:|||:|.:||||||...||:|||||:||:.:|.|...|.||:|
  Fly   262 FASTIGEELFQNGFVPSETDYRVFRDYGHIPGLDMAQTLNGYVYHTKYDRFNLIPRRTYQLTGEN 326

  Fly   373 VLSLVRSISNAEEMYDTEAHSEGHSVFFDYLGLFFVYYTESTGTALNISFSLGAILVICLSLWRM 437
            :|:||::::||||:.:...::|||.:|||.:|.|||||.|:||..:||:..:...:.|.|.:|.|
  Fly   327 ILALVKALANAEELENPSKYAEGHMIFFDMMGWFFVYYPETTGIIINITVCVLVCVTIVLYIWMM 391

  Fly   438 AKVTDRRLGTYAR----AFGMQFLLAILGFLLALGFPLLMSVFYDAGDRTMTYFSNSWLVIGLFI 498
            :..|    |.:.|    .||:...|.:.|..|.:|..:.:::|.||.:..|::||.:|::.||:.
  Fly   392 SSST----GMFRRRIWAKFGILAALQLAGVALGIGLVISIALFLDAVNLPMSWFSQNWMLFGLYF 452

  Fly   499 CPSIIGLVLPATLYLSLRPSEKIPHTYHLQIVGHAYCVFMAVLCILLTVVGIRTAYLFMMCVFFY 563
            ||.|.|:.:...:|.|......:|..|.:|::.|::|:.:.::..::....||:|::.|:|:.||
  Fly   453 CPMIFGMGIVPAIYFSRTKEHGLPLGYGIQLLMHSHCLILTIITAIMVSYSIRSAFVIMLCIGFY 517

  Fly   564 LGALIINLATRLHDKGYLWALVLCVCQILPYLYFTYLFHALLVITIPMTSRKGMDANPDLLISLE 628
            ..:::|||.|:.|...:||.:..|:||:||::::||..:|..|:.:||..|: .:.||::|:...
  Fly   518 TLSVLINLVTKAHKTNFLWLIPHCICQVLPFMFYTYCCYAFYVVFVPMQGRE-CNTNPEILMGFF 581

  Fly   629 CALGSILAMVFLAPLLNLFRRPKAMIGGLTLVMFIFCMISVSDVGFPYRPTTNVMRLHFLEVHRK 693
            .||..:|...||.||..|||:.|.:|....:...:|.:.:.:.:.|||...|...|...:...|.
  Fly   582 TALMVLLFAPFLVPLFCLFRKSKTIISMFGICTIVFIIFAATPIAFPYAEKTAPQRFFAVHTART 646

  Fly   694 FYEFD--GSISLEDSGYYFDLQDRR---FENPLLDKINLTGITRVDDYCKTEMYCGLPCFNHRWC 753
            |:..|  .::|.:||||:....|||   .::.|.:..|.|...|:|  |.:|:.||.|.::.||.
  Fly   647 FHNGDPASTVSHKDSGYFVLPVDRRPHTVDDILFENTNFTKSERID--CDSELMCGFPIYSSRWL 709

  Fly   754 SAVNDARWLPRDEPVDLPGTPILQFLNKTVLGTESAPRALYYFVVSSGPPRMSFFVQPRDGVRML 818
            :||:::.::|..|| :....|.|..|.|    :.::...:.:.:..|||...|.|:.|.:..:::
  Fly   710 NAVDNSYFVPGPEP-NREYIPTLTILEK----SSNSDTNIRFDLEISGPDHTSIFILPLNDSKLV 769

  Fly   819 SWSFLKGMLDNPSVYKPPYHIFFGYGSDDSPVEFYFEMTKDDGNFDGPVVELGISGHYMSHLSKR 883
            .|||::..||..  .||||::::.|..|..|::|..|...:|.|:.|...::.:.||.:......
  Fly   770 DWSFIRDPLDGN--VKPPYYVYWSYALDPKPLQFSLEFEHEDPNWSGGTFKIALMGHRIHDDMYI 832

  Fly   884 DATTQKFIEDLPDFAHPMEWPTSYERY 910
            ....::|:...|.:||...|..||..:
  Fly   833 TEDFREFLATFPPWAHVSSWLGSYNSW 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33012	NP_788335.2	M28_Fxna_like	103..410	CDD:193497	169/306 (55%)
CG9416	NP_001261088.1	M28_Fxna_like	57..364	CDD:193497	169/306 (55%)
CG9416	NP_001261088.1	MFS	423..>624	CDD:304372	62/201 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446914
Domainoid	1	1.000	161	1.000	Domainoid score	I1255
eggNOG	1	0.900	-	-		E1_COG2234
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	212	1.000	Inparanoid score	I1244
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14040at33392
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm25001
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	P	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
	12	11.800