DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33012 and Ermp1

DIOPT Version :9

Sequence 1:	NP_788335.2	Gene:	CG33012 / 36342	FlyBaseID:	FBgn0053012	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_001349060.1	Gene:	Ermp1 / 226090	MGIID:	106250	Length:	899	Species:	Mus musculus

Alignment Length:	856	Identity:	252/856 - (29%)
Similarity:	422/856 - (49%)	Gaps:	86/856 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 IEEEANLPGTFVAQRAESILIRLDLMGPKIAGDYVTEVEMVEFLLGEISKVRDEMRNDLYDMEVD 160
            :...:.|.|.|.|::|...|..:..:||:..|....|:..|::||.:| |:.:...|.|:.:.||
Mouse    91 LSRTSGLQGEFDARQARDYLEHITAIGPRTTGSTENEILTVQYLLEQI-KLIEAQSNSLHSISVD 154

  Fly   161 VQRSSGSF---LHWQMINMYQGIQNVVVKLSSKSSNSTSYLLVNSHYDSKPSSVGTGDAELMVVT 222
            :||.:|||   ......:.|..|.||||||..: ..:.|.:|.|.|:||..:|.|..|..:....
Mouse   155 IQRPTGSFSIDFLGGFTSYYDNITNVVVKLEPR-DGAESAILANCHFDSVANSPGASDDAVSCAV 218

  Fly   223 MLETLRLMATSEETFLHPIVFLFNGAEEQPFHGSHSFISNHRWSANCKALVNLDSAGAGGREILF 287
            |||.||:|:.|.|...|.:|||||||||.....||.||:.|.|::..:|.:||::||.||:|::|
Mouse   219 MLEVLRVMSASPEPMQHAVVFLFNGAEENVLQASHGFITQHPWASLIRAFINLEAAGVGGKELVF 283

  Fly   288 QGGPNHPWLMKQYKKSAKHPFATTMAEEIFQADLIPSDTDFRIFRDFGPVPGLDMAGCYNGFVYH 352
            |.||.:|||::.|..:||||||:.:|:|:||:.:|||||||||:||||.:||:|:|...||::||
Mouse   284 QTGPENPWLVQAYVSAAKHPFASVVAQEVFQSGIIPSDTDFRIYRDFGNIPGIDLAFIENGYIYH 348

  Fly   353 TKFDRYKVISRGALQNTGDNVLSLVRSISNAEEMYDTEAHSEGHSVFFDYLGLFFVYYTESTGTA 417
            ||:|....|...::|..|||:|::::.::.::.:..:..:..|..||||.|||..:.|....|:.
Mouse   349 TKYDTADRILIDSIQRAGDNILAVLKHLATSDTLASSSEYRHGSMVFFDVLGLLVIAYPSRVGSI 413

  Fly   418 LNISFSLGAILVICLSLWRMAKVTDRRLGTYARAFGMQFLLAILGFLLALGFPLLMSVFYDAGDR 482
            :|....:..:|.:...|.|    ...|...|.|.|.....:..:.:..:|...|:::||.....:
Mouse   414 INYMVVMAVVLYLGKKLLR----PKHRNANYMRDFLCGLGITFISWFTSLVTVLIIAVFISLIGQ 474

  Fly   483 TMTYFSNSWLVIGLFICPSIIGLVLPATL---YLSLRPSEKIPHTYHLQIVGHAYCVFMAVLCIL 544
            ::::::..::.:.|:...::..::...||   :..:..|:..............:|.|:    :.
Mouse   475 SLSWYNYFYIAVCLYGTATVAKIIFIHTLAKRFYYMNASDLYLGELFFDTSLFVHCAFL----VA 535

  Fly   545 LTVVGIRTAYLFMMCVFF-YLGALIINLATRLHD-KGYLWALVLCVCQILPYLYFTYLFHALLVI 607
            ||..|..:|::..:.|.| .|..|.:....:.|. :|...||.| :...:||||..||..|:..:
Mouse   536 LTYQGFCSAFMSAVWVVFPLLTKLCVYKDFKKHGAQGRFVALYL-LGMFIPYLYGLYLIWAVFEM 599

  Fly   608 TIPMTSRKGMDANPDLLISLECALGSILAMVFLAPLLNLFRRPKAMIGGLTLVMFIFCMISVSDV 672
            ..|:..|.|.:..||::::...|:..::...:....:.|....|..|..|.||..:..::..|..
Mouse   600 FTPILGRSGSEIPPDVVLASILAVCVMILSSYFITFIYLVNSTKKTILTLILVCAVTFLLVCSGA 664

  Fly   673 GFPY--RPTTNVMRLHFLE-VHRKFYEFDGSISLEDSGYY---FDLQDRRFENPLLDKINLTGIT 731
            .|||  .|.:...:..||: |.|.|:..:||:...|||.:   ||........|.:.:||.|
Mouse   665 FFPYSSNPESPKPKRVFLQHVSRTFHNLEGSVVKRDSGIWINGFDYTGMSHVTPHIPEINDT--- 726

  Fly   732 RVDDYCKTEM-YCGLPCFNHRWCSAVNDARWLPRDEPVDLPGTPILQFL---NKTVLGTESAPRA 792
             :..:|:.:. .||.|     |        :||            :.||   |..:...|.:||.
Mouse   727 -IRAHCEEDAPLCGFP-----W--------YLP------------VHFLIRKNWYLPAPEVSPRN 765

  Fly   793 LYYF-VVS---------------SGPPRMSFFVQPRDGVRMLSWSFLKGMLDNPSVYK-PPYHIF 840
            ..:| :||               :||..|||:|:...|..:..||...|:   |...: ..|.:|
Mouse   766 PAHFRLVSKEKMPWDSIKLTFEATGPSHMSFYVRTHKGSTLSQWSLGNGI---PVTSRGGDYFVF 827

  Fly   841 FGYGSDDSPVEFYFEMTKDDGNFDGPVVELGISGHYMSHLSKR----DATTQKFIEDLPDFAHPM 901
            :.:|...|...|:.|:.:........:|.:.|:.||:|..:||    ||..:||    ||::.|.
Mouse   828 YSHGLQASAWRFWIEVQQVSEEQAEGMVTVAIAAHYLSGENKRSSQLDALKKKF----PDWSFPS 888

  Fly   902 EWPTSYERYIF 912
            .|.::|..::|
Mouse   889 AWVSTYSLFVF 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33012	NP_788335.2	M28_Fxna_like	103..410	CDD:193497	128/309 (41%)
Ermp1	NP_001349060.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
Ermp1	NP_001349060.1	M28_Fxna_like	99..406	CDD:193497	128/308 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835892
Domainoid	1	1.000	247	1.000	Domainoid score	I2148
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121891
Inparanoid	1	1.050	426	1.000	Inparanoid score	I1734
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59376
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000591
OrthoInspector	1	1.000	-	-		otm42620
orthoMCL	1	0.900	-	-		OOG6_101747
Panther	1	1.100	-	-	O	PTHR12147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X435
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760