DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33012 and NAALADL1

DIOPT Version :9

Sequence 1:	NP_788335.2	Gene:	CG33012 / 36342	FlyBaseID:	FBgn0053012	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	NP_005459.2	Gene:	NAALADL1 / 10004	HGNCID:	23536	Length:	740	Species:	Homo sapiens

Alignment Length:	536	Identity:	105/536 - (19%)
Similarity:	166/536 - (30%)	Gaps:	184/536 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VTDGI-DPEEGCSNVTLIELKQKSRFSKQLEWYYSPA-----------------YL-----LFWV 76
            :.||: .|:|...|                .||..|:                 ||     .|.|
Human   222 INDGLSSPDETFPN----------------SWYLPPSGVERGSYYEYFGDPLTPYLPAVPSSFRV 270

  Fly    77 GLFFAVCYPLFNHLPTGVKIEEE--ANLPGTFVAQRAESILIRLDLMGP--KIAGDYVTEVEMVE 137
            .|.....:|.....|.|.:...:  .||.||......:..|.....:||  :..||:..:
Human   271 DLANVSGFPPIPTQPIGFQDARDLLCNLNGTLAPATWQGALGCHYRLGPGFRPDGDFPAD----- 330

  Fly   138 FLLGEISKVRDEMRNDLYDMEVDVQRSSGSFLHWQMINMYQGIQNVVVKLSSKSSNSTSYLLVNS 202
                  |:|...:.|.|     :::.||      .::.:.:|           :.....|:|..:
Human   331 ------SQVNVSVYNRL-----ELRNSS------NVLGIIRG-----------AVEPDRYVLYGN 367

  Fly   203 HYDS------KPSSVGTGDAELMVVTMLETLRLMAT--SEETF--LHPIVFLFNGAEEQPFHGSH 257
            |.||      .||| ||       ..:||..|::.|  .:.|:  ...|||...||||....||.
Human   368 HRDSWVHGAVDPSS-GT-------AVLLELSRVLGTLLKKGTWRPRRSIVFASWGAEEFGLIGST 424

  Fly   258 SFISN--HRWSANCKALVNLDSAGAGGREILFQGGPNHPWLMKQYKKSAKHPFATTMAEEIFQ-- 318
            .|...  ::......|.:|:|.:......:..||.|....::....|..:.|....::  |:.
Human   425 EFTEEFFNKLQERTVAYINVDISVFANATLRVQGTPPVQSVVFSATKEIRSPGPGDLS--IYDNW 487

  Fly   319 ----------ADLIPS------DTDFRIFRDFGPVPGLDMAGCYNGF--------VYHTKFDRYK 359
                      ..|:||      .:|:..|..|..:..:|:|..|:..        .|||.||.:.
Human   488 IRYFNRSSPVYGLVPSLGSLGAGSDYAPFVHFLGISSMDIAYTYDRSKTSARIYPTYHTAFDTFD 552

  Fly   360 VI---------SRGALQNTGDNVL-----------------SLVRSISNAEEMYDTEAHSEGHSV 398
            .:         |..|:..|..:|:                 ..:||...|.:. |..|..|.||:
Human   553 YVDKFLDPGFSSHQAVARTAGSVILRLSDSFFLPLKVSDYSETLRSFLQAAQQ-DLGALLEQHSI 616

  Fly   399 FFDYLGLFFVYYTESTGTALNISFSLGAILVICLSLWRMAKVTDRRLGT---------YARAFGM 454
                                    |||.::.........|....:|:.|         ..|....
Human   617 ------------------------SLGPLVTAVEKFEAEAAALGQRISTLQKGSPDPLQVRMLND 657

  Fly   455 QFLLAILGFLLALGFP 470
            |.:|....||....||
Human   658 QLMLLERTFLNPRAFP 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33012	NP_788335.2	M28_Fxna_like	103..410	CDD:193497	74/372 (20%)
NAALADL1	NP_005459.2	Zinc_peptidase_like	46..>121	CDD:387401
		PA_GCPII_like	109..335	CDD:239036	27/139 (19%)
		M28_PSMA_like	<348..587	CDD:349942	53/259 (20%)
		TFR_dimer	616..735	CDD:367885	13/82 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900