DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33012 and NAALAD2

DIOPT Version :9

Sequence 1:	NP_788335.2	Gene:	CG33012 / 36342	FlyBaseID:	FBgn0053012	Length:	912	Species:	Drosophila melanogaster
Sequence 2:	XP_016872532.1	Gene:	NAALAD2 / 10003	HGNCID:	14526	Length:	775	Species:	Homo sapiens

Alignment Length:	409	Identity:	91/409 - (22%)
Similarity:	137/409 - (33%)	Gaps:	129/409 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 NLPGTFVAQR------------------AESILIRLDL---MG-PKIAGDYV--TEVEMVEFLLG 141
            ||||| .|||                  |:....|||:   :| |:|....:  .:.|::...||
Human   272 NLPGT-AAQRGNVLNLNGAGDPLTPGYPAKEYTFRLDVEEGVGIPRIPVHPIGYNDAEILLRYLG 335

  Fly   142 EISKVRDEMRNDLYDMEVDVQRSSG-------SF----LHWQMINMYQGIQNVVVKLSSKSSNST 195
            .|:......:..|     :|..|.|       ||    :|...||....|.|||..:.. |....
Human   336 GIAPPDKSWKGAL-----NVSYSIGPGFTGSDSFRKVRMHVYNINKITRIYNVVGTIRG-SVEPD 394

  Fly   196 SYLLVNSHYDSKPSSVGTGDAELMVVTMLETLRLMATSEETFLHP---IVFLFNGAEEQPFHGSH 257
            .|:::..|.||  ...|..|....|..:.|..|...........|   |:|....|||      .
Human   395 RYVILGGHRDS--WVFGAIDPTSGVAVLQEIARSFGKLMSKGWRPRRTIIFASWDAEE------F 451

  Fly   258 SFISNHRWS-ANCK-------ALVNLDSAGAGGREILFQGGPNHPWLMKQ--YKKSAKHPF---- 308
            ..:.:..|: .|.|       |.:|.||:..|...:.....|    |:.|  ||.:.:.|.
Human   452 GLLGSTEWAEENVKILQERSIAYINSDSSIEGNYTLRVDCTP----LLYQLVYKLTKEIPSPDDG 512

  Fly   309 --ATTMAEEIFQADLIP------------SDTDFR-IFRDFGPVPG---------LDMAGCYNGF 349
              :.::.|...:.|..|            |.:||. .|:..|...|         .|....|.
Human   513 FESKSLYESWLEKDPSPENKNLPRINKLGSGSDFEAYFQRLGIASGRARYTKNKKTDKYSSYP-- 575

  Fly   350 VYHTKFDRYKVIS----------------RGAL--------------QNTGDNVLSLVRSISNAE 384
            ||||.::.::::.                ||||              |:..:.:.:...||.|..
Human   576 VYHTIYETFELVEKFYDPTFKKQLSVAQLRGALVYELVDSKIIPFNIQDYAEALKNYAASIYNLS 640

  Fly   385 EMYDTEAHSEGHSVFFDYL 403
            :.:|.:.  ..|.|.||.|
Human   641 KKHDQQL--TDHGVSFDSL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33012	NP_788335.2	M28_Fxna_like	103..410	CDD:193497	89/407 (22%)
NAALAD2	XP_016872532.1	Zinc_peptidase_like	93..>139	CDD:301362
		PA_GCPII_like	145..371	CDD:239036	25/104 (24%)
		M28_PSMA_like	373..620	CDD:193568	55/261 (21%)
		TFR_dimer	657..772	CDD:282153	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2234
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900