DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ana3 and Rttn

DIOPT Version :9

Sequence 1:	NP_610765.1	Gene:	ana3 / 36341	FlyBaseID:	FBgn0266111	Length:	1977	Species:	Drosophila melanogaster
Sequence 2:	NP_001163907.2	Gene:	Rttn / 291377	RGDID:	1306706	Length:	2228	Species:	Rattus norvegicus

Alignment Length:	2447	Identity:	476/2447 - (19%)
Similarity:	847/2447 - (34%)	Gaps:	715/2447 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GQLTKLTSESEEIRMRALD----QIETRFIRCLQLGEPIQFKPVLLLKQLIRWFGYTPPLVP--D 72
            |.:.||..:..|||.|||.    :||...|.|..|   ||.:  ||...|:.||.:  |.||  :
  Rat     5 GLIRKLGHQLTEIRERALKSILCKIEHNLICCADL---IQER--LLFLHLLEWFNF--PSVPMKE 62

  Fly    73 RVLAMIMELLRSEYAEAVIRKIPYERFKAELQKVRRVLHKQESKRVSELLDDMNLLLLEKYNIDR 137
            .||.::..|::  |..||...|.....:. |.|:|..:.......:..:||.:.:|..|
  Rat    63 EVLNLLSRLVK--YPPAVQHLIDLGAVEF-LSKLRPNVEPAIQAEIDGILDGLFILPSE------ 118

  Fly   138 VTPSVSSLS----SNDIPSQATESADSSSNQIYDNLKPEDYEP--------SWSH----PCLDDV 186
             .|::.|.:    .|:: ||..|.......|...||:..:..|        .|..    |.|...
  Rat   119 -VPALRSATYQPDQNEL-SQQPEVLTGYFPQDKSNLQQMEVPPGPVGNPTVKWLRFSVFPWLPLT 181

  Fly   187 ATMKSMIDLPRNSVE-----LQLQLTELI--IRMGDYPTEYFLQPPFV---FLHLVQLQTMTDGS 241
            .|.:.::....:|:.     |.....||:  :.|.|:|.|.|||.|.:   .|.||:|....||.
  Rat   182 TTDRHVLSSNESSLRSSNHTLIWNTCELLKDVIMQDFPAEIFLQRPKIVQGLLCLVKLAFGGDGK 246

  Fly   242 LIHVNRAL--IACLRLL-------------------QQRILLRRNTLSYADRFDPP--------- 276
              | ..||  ::||:.|                   :|..:.:.::|||......|
  Rat   247 --H-RLALQSVSCLQQLCTSLRNRLNFYRDPNLFSNKQDTISQNSSLSYCHEARGPYHSPNPSPG 308

  Fly   277 ---SRPK------------------------------------------------QVKVVSALVI 290
               |||.                                                :::...||.:
  Rat   309 SSSSRPSVVGRTGQRPRGDGQDWDAVSSSGSSSHAHVNSRLSVRSPLDVAHADLPELETEDALEL 373

  Fly   291 ------LLENCMKLIR---PLLFSCTNDN-WHIMELIVE-IVRTHDVLSSKIPLVSITLIADAVK 344
                  |.:.|:..:.   |||.:.:.:. ..::||:.| ::.....:||:|...:.....|..:
  Rat   374 HFQQLSLPQFCISTLDAAVPLLRTGSREMVIRVLELLGEDLLLIGQAISSEIWDDNSLFAIDVKE 438

  Fly   345 SLLAYCNSVEGSCMTQLMDSLRIPRLQSLILNGVLHDMVALNIN-YDKRMDRRQAKALIQPIVLD 408
            .||....|: |..|.....|..:.:.::::::   |.|..::|: :..|:     ..::.|:...
  Rat   439 KLLQVLGSL-GETMCYRKTSFSLEQAEAILVH---HRMAFVSISLFTVRL-----LQILLPVEKA 494

  Fly   409 SAYLSGMPERMKSLNTLISSLDSGPSPDEELIKLKRAYSVALNQLHPNTELTGSLLIQKYRQVCL 473
            |.:|   ||.|.:....:|              |....|:...::|..              |..
  Rat   495 SEFL---PESMSAALFFVS--------------LDMPISLEYPEIHDT--------------VVA 528

  Fly   474 VLVQLGSE--TLVKQLFGAV--VKCIPFYAGNLKLRKDADELLYTLVDLPALKLRSLIYRLMIKS 534
            .|.||.||  ::.|:...||  ::|...:..:  :.|:.::.|..||:|....|||..|
  Rat   529 YLEQLDSENYSIYKRTAEAVYSIECTCNFLSD--VGKEGEKNLLELVELADQALRSFSY------ 585

  Fly   535 TVAHFHSFMNKTVYMTGCSNV--------------DLIRQHILGVPLTPLLLRRM-----IIQS- 579
               |.||.:.|.|... ||.:              ..:..|:|..||..:.:...     |::.
  Rat   586 ---HQHSPLIKEVICL-CSKIWKSAQASPLLQGESQKVFLHMLSHPLPQVKVETYQCCLEIVKEC 646

  Fly   580 -SEANTSERMQQWC-----LDYPIMIMKLNA--------------------------ILAPQDFS 612
             ...|.::.:...|     |.:|.::.:::|                          ::....::
  Rat   647 LGVHNVTKPVSSLCSGIHFLLHPKVLYEISAFGIQESKNEVNAAAKAVLLYLLQGRFMMTALTWN 711

  Fly   613 VVFPLLLPVLPLLISRSVTHKILHNVIWNVLEPDSSRLDPQLM-----LRGYVYFMFHPDGEVRS 672
            .....|.||:|:|...:.|...|.|.|. :|...||.....::     |:..:..:......|||
  Rat   712 KFIESLCPVIPVLQGYADTEDPLGNCIL-LLSKVSSETGEGILPCTTRLKSVLRLLLVKKPSVRS 775

  Fly   673 EATTTIAYVLQCQEQTNRYLPTASNVPVEHIANDLCIIQPPFCYRSIFIKCSDER--FQGQRSLD 735
            .|...:|:.|..:|..:...|......:..:.| |.|::.|     |.:|..|.|  .....::.
  Rat   776 LALKLLAFHLTGEEGADTKRPFVDARVLSRVTN-LFIVKKP-----IDLKLDDRRELVIKLETVK 834

  Fly   736 ALFRLLQAKDIKSNIRKSTMTQLNVLLRNWRACEEFSTKEDGYRLIMESLHNALKK--------- 791
            .::.:..:.|:...:|||...||.|::::.:                  :|..:||
  Rat   835 KVYEIFTSDDVDLVLRKSAAEQLAVIMQDIK------------------MHTVVKKLCLIEKIIG 881

  Fly   792 ------GNDTDI----LLPTVSILMKLLFNDDEFRLEVANTFGVYTLLLRALFLFPHLEQLRQDV 846
                  |.|..:    :.|.:::|.|::..|...|..::....:.|||||...:|      .:|.
  Rat   882 YLNEFVGQDGKVIECLIRPCLTLLRKVVCADLVIRASLSQQASLLTLLLRVSLIF------HEDC 940

  Fly   847 SI--------CLFQMLFQNCITSTEDKLVLNANMEPLI---------------LPVTYEIEHKVI 888
            ::        ||  :||..  .|..|....|::.:|.:               |||.....|.|.
  Rat   941 AVVAEVGALFCL--LLFDE--VSRMDMWSDNSSNKPSLSSVFSLPVSVFRRYHLPVYVNGHHAVS 1001

  Fly   889 PTAVTEGLELQQNVEATHFGRDRAKAAQHWRLYMAYRVCQVPSSITLESVSALDIRESLKIKMAD 953
            |.::.  |.|.....|.....|..:.|  |.|...:....:....|.|: ...:..::|::...|
  Rat  1002 PYSIV--LPLSTECLALKPVSDMLRIA--WNLAWYHGSDNLLKQTTSET-KIQEFSDTLQLSTED 1061

  Fly   954 LALVRSSDLNEQLSCQFIAAENCSKHEDLQKTVSAIQLFLVVLRNSLSD-------TVAENLW-K 1010
            :..::.:..:..|.....:......|.|::..::.:..:|:..:.||.|       |:....| .
  Rat  1062 ILTLKITYTDSGLKDCLQSIVQAGGHRDVRAAITRMSFYLLNDKLSLKDDIGPCGFTLKSLAWHT 1126

  Fly  1011 LIHKYIRLAPGNEADDKVYKSMLDLCVTCIRFSQPH-AINGLSYALETDHHHSFQLLLHDSQISL 1074
            ::::::::.|....|:|:...::......|:..:.: ::..|::.||.       ||.|:....|
  Rat  1127 VLNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNPSVELLNWILEL-------LLRHNPNPLL 1184

  Fly  1075 DKLFLICQCMMQLLSNELSDDSMNWYGKFFMQLSAVAKTHFELRQLQHVRCILCMLRFVSER--- 1136
            |.|.|     .:..:.|::|:         ::.:...:...||..|.:...::||.  ||:|
  Rat  1185 DLLVL-----TESHTREVTDE---------IRTAVRQQLQKELITLLNSLLLVCMT--VSDRKCL 1233

  Fly  1137 ----------NLKFSNAQLMSYSQHFIQLSSNLRT----STQTGSE-WQRD---------C---- 1173
                      :||......::.:.||..|.|..||    :..|.|. |...         |
  Rat  1234 ELFYVFQTQLSLKLLQCLRVTDAPHFYGLPSLERTLAGMAHLTASPGWSAHSPLSKPLEICGKYL 1298

  Fly  1174 ---------LY-------------------IICQLQI--HLIYQEPKAS------------SKAS 1196
                     .|                   ::|.|.:  .:|.|.|.:.            |:.:
  Rat  1299 SGLLEVITSFYVERGGNAMSFMGKGVTKSTVLCLLHLSHEMIVQAPNSEWMPLWFLPLGSHSEEN 1363

  Fly  1197 IPNDVGASYKVLRYFLTLCGHGDSEVRALSWVSLANWITICGSQVAEILPRLDFLPGGLPACCLT 1261
            :|:..|     |.:.:.|....|.|||..| :.|.:.:|...:....:......:.|||....:.
  Rat  1364 VPSQQG-----LAWLIPLWVDRDPEVRFTS-LGLGSALTTMEAGCVALANSCQNISGGLWGTVVN 1422

  Fly  1262 TLTDAHEMMLIRELAGRVF--ILLMPL-----------------------IGAESSLELLRKH-- 1299
            .|.|..|..::|..|..:.  :|::|:                       :..:.:|:.|..|
  Rat  1423 ILLDQSECSMVRREAAFILQNLLVIPMPSKVIKDYTWQGPCVHDEDSGLSLSGKPALQALLYHCR 1487

  Fly  1300 ------DLLK-------------------TAYNSLKAIHDT------------------------ 1315
                  .::|                   :.||.|..:.|:
  Rat  1488 FYEHLTHMVKHCYVGRYMFDFNISAFTETSEYNDLNGLDDSFKFWRAPSGTSTQDHEPSSLSTSE 1552

  Fly  1316 -----------------------PWMFKKIV--GERHSCEVI-----SCYVAICTKMVAMKPEWC 1350
                                   |....:.|  |..||...:     |...::..:.|.:.|...
  Rat  1553 TMVAASVVSAEIQPLLPSTLLPEPAALDQFVTQGHLHSVRPVRPRDSSPSASLHRQCVFVTPSLL 1617

  Fly  1351 AALCGHSLMSGLSDVMKKLKSQASCSIPLVE-LCASQICELYSMCYTNNFEFLKM------TICR 1408
            :|:|  ||:..|..|..:..:.|.....|:| ||::....|..||.......|.:      |..:
  Rat  1618 SAVC--SLLDNLLAVTPRDAANAFQQAHLIELLCSTMDASLLEMCVQELKTPLSLSSAVEHTQAQ 1680

  Fly  1409 DSVFLQNYLTLINDVL--------SLECPEYMVIPLLK---MFLIFCTDSNSNSFLIEQIKNKPS 1462
            .|.||: ||:.:..:|        .|...:.::.||:.   ..||.||....:..|:
  Rat  1681 TSFFLE-YLSSLFQLLKSCLLVDPKLVTQDELLKPLITNVIRVLIVCTKDVLDVQLV-------- 1736

  Fly  1463 LFMDF-----FLFGLHVKLINSPFQRFTLSALSLVFTKAQLAAYDISMLSELEK----------- 1511
              :.|     .||.|...|:..      ..|:|||...:.||.:..::...|.:
  Rat  1737 --LAFHRTWTHLFDLLATLLRK------AGAVSLVPLTSALAKHWEAVTDTLCRCVGLSVKCPAL 1793

  Fly  1512 --FELAFSDPDIAKDGKQEFESKKKQSVSQCIYDESSDNSDDNKQRPNHA--IQATNAAIIIFHR 1572
              ..|.|....:|::.|:..:.|.|  .:.|             |.|..|  :..|..::....|
  Rat  1794 SIASLQFLSVLLAEEEKRRVQDKDK--TNAC-------------QTPTVAFLLDGTQGSLRSSER 1843

  Fly  1573 LDQ-LFDRYYLSKALNFLELPAVGQVQVCEALGELLKASTWAVKAAGESKLLGKVV----HILDD 1632
            |:: :...|....:.:.|:..|      ..||..||..|..|.:.|.:|.|:...|    || :.
  Rat  1844 LNETILQCYEGISSKDVLKRVA------ANALMSLLAVSRRAQRHALKSDLIENCVEQMKHI-NA 1901

  Fly  1633 FLNDEKI--GNAAVYVKRVGPHKAQSIISNLLVLINMLSQWHSSPNSEIIQTSMAANIAKILIRI 1695
            .||.:.:  |.||:..|..|..|..||  .|.:|.|.|.|     |.|....:..|::..:|..:
  Rat  1902 QLNLDVLRPGKAALKKKEDGIIKELSI--TLQLLRNCLYQ-----NEECKVAAFEAHLVPVLHSL 1959

  Fly  1696 WPWLSHSYHLKKVTVQLIMFLTEHSFEMCKQI------SLLQSGH----AQSLLHLMARVADFET 1750
            ||||.....|.::.:||:...|.:....|..:      ..:|:.|    :.||:....::|. :.
  Rat  1960 WPWLLMEDSLMQIALQLLCVYTANFPTGCSSLCWSNYGQYIQTAHRGTPSSSLILCALKLAS-QV 2023

  Fly  1751 TKKEIPNKEPSLNMVPALRVMVNCCCCTEGRLSLSKMNLLDMFDTILPANPCSTHLKVRPPVLIA 1815
            ..:..|.::.....:..|.:..:|      :..:.|.|.|..|.::......:.||.   .|.|.
  Rat  2024 PAENTPIQQAVFMFLSNLALSHDC------KGVIQKSNFLQHFLSLTLPKGGNQHLS---NVTIL 2079

  Fly  1816 WL------GFWE----VFSRYDVGGKACHLQSLIN----TIRRSPPLSHKRILCLRILRNMCFFN 1866
            ||      .|.|    :..|.|    .| |..||.    |.:.||   |..:|   |..|:|...
  Rat  2080 WLKLLLNMSFGEDGQQMILRLD----GC-LDLLIEMSKYTHKSSP---HVPLL---IFHNICCSP 2133

  Fly  1867 GNRPRLVELADFINLLRDILEQRVQKAPTSEKNGLNSFEEHRLAVLMLWKLFGFGAKYKGMLRGT 1931
            .|:|:::.....:.||...||...|.|             .|:....||.|.....|.|..|:..
  Rat  2134 ANKPKILANEKVVTLLATCLESENQNA-------------QRIGAASLWALTYNYQKAKATLKNP 2185

  Fly  1932 KLFKLLIGLRVEMSVVFSEEENKYAGVPYANDLAKLLEKLME 1973
            .:.:.:..........||..|..    |..:...|.||.|::
  Rat  2186 SIKRKIDEAYSIAKRTFSNSEED----PLNSYYLKCLENLVQ 2223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ana3	NP_610765.1	RTTN_N	25..120	CDD:291396	31/100 (31%)
Rttn	NP_001163907.2	RTTN_N	16..112	CDD:291396	33/105 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363892at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR31691
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110