Protein Alignment ana3 and RTTN

DIOPT Version :9

• Sequence 1: NP_610765.1
• Gene: ana3 / 36341
• FlyBaseID: FBgn0266111
• Length: 1977
• Species: Drosophila melanogaster
• Sequence 2: XP_006722497.1
• Gene: RTTN / 25914
• HGNCID: 18654
• Length: 2227
• Species: Homo sapiens
• Alignment Length: 2459
• Identity: 468/2459 - (19%)
• Similarity: 849/2459 - (34%)
• Gaps: 734/2459 - (29%)

  Fly    14 GQLTKLTSESEEIRMRALD----QIETRFIRCLQLGEPIQFKPVLLLKQLIRWFGYTPPLVP--D 72
            |.:.||..:..|||.|||.    :||...|....|   ||.:.:.|  .|:.||.:  |.||  :
Human     5 GLIRKLGHQLAEIRERALKSILCKIEHNLICYADL---IQERQLFL--HLLEWFNF--PSVPMKE 62

  Fly    73 RVLAMIMELLRSEYAEAVIRKIPYERFKAELQKVRRVLHKQESKRVSELLDDMNLLLLEKYNIDR 137
            .||.::..|::  |..||...:.....:. |.|:|..:.......:..:||.:.||..|
Human    63 EVLNLLSRLVK--YPPAVQHLVDVGAVEF-LSKLRSNVEPNLQAEIDGILDGLFLLPSE------ 118

  Fly   138 VTPSVSSLSSNDIPSQATESADSSSNQIYDNLKPED---YEPSWSHP---------CL------- 183
             .|::||.|     .|..::..|.:.:|.....|:|   ::.....|         ||
Human   119 -VPALSSAS-----YQTNQTELSKNPEILTGYFPQDKSNFQQMEVPPRPVVNQTVKCLKFSTFPW 177

  Fly   184 -------------DDVATMKSMIDLPRNSVELQLQLTELIIRMGDYPTEYFLQPPFVFLHLVQLQ 235
                         ::.:...|...|..|:.||   |.::|  |.|:|.|.|||.|.:...|:.|.
Human   178 LPLTTTDRHVLSSNESSLRSSNHTLIWNTCEL---LKDVI--MQDFPAEIFLQRPKIVQSLLSLL 237

  Fly   236 TMTDGSLIHVNRALIACLRLLQQRILLRRNTLS-------YADRFDPPSRPKQVKVVSALVILLE 293
            .:..|...|  |..:..:..|||..:..||.|:       ::::.|..|:...          |.
Human   238 KLAFGDGKH--RLALQSVSCLQQLCMYLRNRLNFHRDPGFFSNKHDTVSQNSS----------LS 290

  Fly   294 NCMKL---------------IRPLLFSCT-------NDNW------------HIMELI------- 317
            .|.:.               .||.:...|       ..:|            |:...|
Human   291 YCHEARGTHHSQNPSPGSSSPRPSVVGRTGQRPRGDGQDWDAASSSGSSSHAHVNSRISVHSPLD 355

  Fly   318 ---VEI--VRTHD-----------------VLSSKIPLV-----------------SITLIADAV 343
               :::  :.|.|                 :|.|.:||:                 .:|||.:|:
Human   356 MGHIDLPELETEDTLELQFQQLSLPQFCVSILESAVPLLRTGSRQVIIRVLELLTEDMTLIGEAI 420

  Fly   344 KSLLAYCNSVEGSCMTQLMDSLRIPRLQSLILNGVLHDMVALNINYDKRMDRRQAKALIQPIVL- 407
            .:.:...:|:.|..|.:.:          |::.|.|.:.:..:         :.:.:|.||.|:
Human   421 STDIWDDSSLFGIDMKEKL----------LLVLGALGETMCYH---------KSSISLEQPEVML 466

  Fly   408 ---DSAYLSGMPERMKSLNTLISSLDSGPSPDEELIK-LKRAYSVALNQL---------HPNTEL 459
               ..|::|.....::.|.||:        |.|:..: |....|.||..|         :||.
Human   467 VHHRMAFISISLFAVRLLQTLL--------PVEKASEFLSEPMSTALFLLSLDMPISLEYPNI-- 521

  Fly   460 TGSLLIQKYRQVCLVLVQLGSE--TLVKQLFGAV--VKCIPFYAGNLKLRKDADELLYTLVDLPA 520
                    :..|...|.||.||  ::.|:...||  ::|...:..:  :.|:.::.|..||:|..
Human   522 --------HEAVVAYLEQLNSENYSIYKRTAEAVYSIECTCNFLSD--IGKEGEKNLLELVELAD 576

  Fly   521 LKLRSLIYRLMIKSTVAHFHSFMNKTVYMTGCSNV--------------DLIRQHILGVPLT--- 568
            ..|||..|         |.|..:.|.: ::.||.:              ..:..|:|..||.
Human   577 QALRSFSY---------HQHFPLIKEI-ISICSKIWKSAQASPLLQGESQKVLLHMLSHPLPRVK 631

  Fly   569 ------------------------------------PLLLRRMII------QSSEANTSER-MQQ 590
                                                |.:|..:.:      :|.:.||:.: :..
Human   632 AETYHCCLEITKECLGVHNVTKPVSSLCNGIHFLLHPKVLYEISVFGIQEPESEQVNTAAKAILL 696

  Fly   591 WCLDYPIMIMKLNAILAPQDFSVVFPLLLPVLPLLISRSVTHKILHNVIWNVLEPDSSRLDPQL- 654
            :.|...:|:..|.       ::.....|.||:|:|...:.|...|.|.|. :|...||..:..|
Human   697 YLLQGRLMMTALT-------WNKFIESLCPVIPILQGYADTEDPLGNCIL-LLSKASSDTEEMLP 753

  Fly   655 ---MLRGYVYFMFHPDGEVRSEATTTIAYVLQCQEQTNRYLPTASNVPVEHIANDLCIIQPPFCY 716
               .|:..:..:......|||.|...:|:.|..:|..:...|......:..: .||.|.:.|
Human   754 CTTRLKSMLRLLLVKKPSVRSLALKLLAFHLTSEEGADTKRPLIDARVLSRV-TDLFIGKKP--- 814

  Fly   717 RSIFIKCSDER--FQGQRSLDALFRLLQAKDIKSNIRKSTMTQLNVLLRNWRACEEFSTKEDGYR 779
              |.::..|.|  .....:::.::.:..:.|:...:|||...||.|::::.:
Human   815 --IELRLDDRRELVIKLETVEKVYEIFTSDDVDLVLRKSAAEQLAVIMQDIK------------- 864

  Fly   780 LIMESLHNALKK------------------GNDTDILL-PTVSILMKLLFNDDEFRLEVANTFGV 825
                 :|..:||                  |...:.|: |.:::|.|:|..|...|:.::....:
Human   865 -----MHAVVKKLCLIDKIIEYLNECVSQDGKVVECLVQPCLTLLRKVLCGDPVMRVSLSQQSSL 924

  Fly   826 YTLLLRALFLFPHLEQLRQDVSI--------CLFQMLFQNCITSTEDKLVLNANMEPLI-----L 877
            .|:|.|...:|      .:|.|:        ||  :||..  .|..|...:|.:.:|.:     |
Human   925 LTVLFRVSLIF------HEDCSVVTEVGALFCL--LLFDE--VSRMDMWSVNPSNKPSLPSVFSL 979

  Fly   878 PVT----YEI------EHKVIPTAVTEGLELQQNVEATHFGRDRAKAAQHWRLYMAYRVCQVPSS 932
            ||:    |.:      .|.|.|.::.  |.|..:..|.....|..:.|  |.|...:....:...
Human   980 PVSVFRRYHLPVHVIGHHAVSPYSIV--LPLSADCLALKPVSDMLRIA--WNLSWYHGSDNLLKQ 1040

  Fly   933 ITLESVSALDIRESLKIKMADLALVRSSDLNEQLSCQFIAAENCSKHEDLQKTVSAIQLFLVVLR 997
            :..|: ...:|.::||:...|:..::.:.:...|.....:....:.|.:::..|:.:..:|:..|
Human  1041 MNSET-KTQEILDALKLSTEDILTLKITHMASGLQDCLHSIVQAATHREVRAAVTRMSFYLLNDR 1104

  Fly   998 NSLSD-------TVAENLW-KLIHKYIRLAPGNEADDKVYKSMLDLCVTCIRFSQPH-AINGLSY 1053
            .||..       |:....| ..:::::::.|....|:|:...::......|:..:.: ::..|::
Human  1105 LSLKGCPGPCGVTLKSLAWHTALNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNSSLELLNW 1169

  Fly  1054 ALETDHHHSFQ-----LLLHDSQ--------------------ISLDKLFLI---------CQCM 1084
            .||....||..     |:|.:||                    |:|....|:         |..:
Human  1170 ILELLLRHSANPLLDLLVLTESQAREETDDIRTAVRQQLQKELIALFDTLLLNFMEVTDRKCSEL 1234

  Fly  1085 MQLLSNELS---------DDSMNWYGKFFMQLSAVAKTHFELRQLQHVRCI-------------- 1126
            :.:...:|:         .|:.::||     |.::.:|   ||.:.::...
Human  1235 LYVFQTQLALKLLQCLKVTDAPHFYG-----LPSLERT---LRGMANLTAFPGWSSHSPLTKPLD 1291

  Fly  1127 LCMLRFVSERNLKFSNAQLMSYSQHFIQLSSNLRTSTQTGSEWQRDCLYIICQLQIHLIYQE--- 1188
            :|         :|:.:..|...:..:::...|..:....|.....    |:|.|  ||.::.
Human  1292 IC---------VKYLSGLLEVITSFYVERGGNAMSFMGKGVTKST----ILCLL--HLSHEMMAQ 1341

  Fly  1189 ------------PKAS-SKASIPNDVGASYKVLRYFLTLCGHGDSEVRALSWVSLANWITICGSQ 1240
                        |..| |:..||...|     |.:.:.|....|.|||..| :.|.:.:|...:.
Human  1342 AGSLEWMSLWFLPLGSHSEEHIPTQQG-----LAWLIPLWVDRDPEVRFTS-LGLGSALTTLETG 1400

  Fly  1241 VAEILPRLDFLPGGLPACCLTTLTDAHEMMLIRELAG----RVFILLMP---------------- 1285
            ...:......:.|||....:..|.|..|..::|..|.    .:.::.||
Human  1401 CVALANSCQNISGGLWGTVVNILLDQSECSMVRREAAFILQNLLVIPMPTEIIKDYTWQGPCVHD 1465

  Fly  1286 ------LIGAESSLELLRKH--------DLLKTAY-------------------NSLKAIHDT-- 1315
                  ||| :.:|:.|..|        .::|..|                   |.|..:.|:
Human  1466 EDSGLSLIG-KPALQALLYHCHFYEHLNQMVKHCYLGRCMFDLNFSAFDRNSESNDLNGLDDSFK 1529

  Fly  1316 -------------------------PWM----FKKIV-----------------GER-------- 1326
                                     |.:    |:.:|                 |.:
Human  1530 FWRAPSRTSQDRDPSSLSTSETTVAPSLGSTEFQPLVQSTTLLPEASHDQFVAQGHQESTSPRPP 1594

  Fly  1327 HSCEVISCYVAICTKMVAMKPEWCAALCGHSLMSGLSDVMKKLKSQASCSIPLVE-LCASQICEL 1390
            |...:.:....:|   |.:.|...:|:|  ||:..|..:..:..::|.....|:| ||:.....|
Human  1595 HDSSLSAPLPKLC---VFVTPSLLSAMC--SLLDNLLTIAPRDTAKAFRQAHLIELLCSIADATL 1654

  Fly  1391 YSMCYTNNFEFLKMTICRDSV-----FLQNYLTLINDVL--------SLECPEYMVIPLLKM--- 1439
            ...|.......|..:...:..     ||..||:.::.:|        .|...:.:|.||:..
Human  1655 IQTCVQELRALLPSSPPAEHTQAQVSFLLEYLSSLSRLLQSCLLVEPDLVIQDELVKPLITNIIG 1719

  Fly  1440 FLIFCTDSNSNSFLIEQIKNKPSLFMDFF--LFGLHVKLINSPFQRFTLSALSLVFTKAQLAAYD 1502
            .|..||....:..||       |.|...:  ||.|...|:... ...||..:::...|...||.|
Human  1720 ILTICTKDVLDKELI-------SAFYHTWTHLFNLLAMLLRKA-GAITLPFVTVALAKHWTAAID 1776

  Fly  1503 I--------SMLSELEKFELAFSDPDIAKDGKQEFESKKKQSVSQCIYDESS--DNSDDNKQRPN 1557
            :        :....|....|.|....:.::.|...::|.|..:. |....:|  |:|.:|::
Human  1777 MFCTCAGLSATCPALYTASLQFLSVLLTEEAKGHLQAKSKTHLC-CSPTVASLLDDSQENQK--- 1837

  Fly  1558 HAIQATNAAIIIFHRLDQLFD---RYYLSKALNFLELPAVGQVQVCEALGELLKASTWAVKAAGE 1619
                          .|:||.|   :.|..|:...: |..|    ...||..||..|..|.|.|.:
Human  1838 --------------SLEQLSDVILQCYEGKSSKDI-LKRV----AANALMSLLAVSRRAQKHALK 1883

  Fly  1620 SKLLG----KVVHILDDF-LNDEKIGNAAVYVKRVGPHKAQSIISNLLVLINMLSQWHSSPNSEI 1679
            :.|:.    ::.||.... |:..:.|.||:..|..|..|..||...|  |.|.|.|     |.|.
Human  1884 ANLIDNCMEQMKHINAQLNLDSLRPGKAALKKKEDGVIKELSIAMQL--LRNCLYQ-----NEEC 1941

  Fly  1680 IQTSMAANIAKILIRIWPWLSHSYHLKKVTVQLIMFLTEHSFEMCKQISL-------LQSGH--- 1734
            .:.::.|::..:|..:|||:.....|.::::||:...|.:....|..:..       :|:.|
Human  1942 KEAALEAHLVPVLHSLWPWILMDDSLMQISLQLLCVYTANFPNGCSSLCWSSCGQHPVQATHRGA 2006

  Fly  1735 -AQSLLHLMARVADFETTKKEIPNKEPSLNMVPALRVMVNCCCCTEGRLSLSKMNLLDMFDTILP 1798
             :.||:..:.::|      .::|.:..::..: ...::.|.....:.:..:.|.|.|..|.::..
Human  2007 VSNSLMLCILKLA------SQMPLENTTVQQM-VFMLLSNLALSHDCKGVIQKSNFLQNFLSLAL 2064

  Fly  1799 ANPCSTHLKVRPPVLIAWLG-FWEVFSRYDVGGKACHLQSLINTIRRSPPLSHKR--ILCLRILR 1860
            ....:.||.   .:.|.||. ...:.|..|.......|...::.:.......||.  :|.|.|..
Human  2065 PKGGNKHLS---NLTILWLKLLLNISSGEDGQQMILRLDGCLDLLTEMSKYKHKSSPLLPLLIFH 2126

  Fly  1861 NMCFFNGNRPRLVELADFINLLRDILEQRVQKAPTSEKNGLNSFEEHRLAVLMLWKLFGFGAKYK 1925
            |:||...|:|:::.....|.:|...||...|.|             .|:....||.|.....|.|
Human  2127 NVCFSPANKPKILANEKVITVLAACLESENQNA-------------QRIGAAALWALIYNYQKAK 2178

  Fly  1926 GMLRGTKLFKLLIGLRVEMSV-----VFSEEENKYAGVPYANDLAKLLEKLMES 1974
            ..|:...:.:     ||:.:.     .|...|.......|...|..|::.|..|
Human  2179 TALKSPSVKR-----RVDEAYSLAKKTFPNSEANPLNAYYLKCLENLVQLLNSS 2227

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ana3	NP_610765.1	RTTN_N	25..120	CDD:291396	28/100 (28%)
RTTN	XP_006722497.1	RTTN_N	16..112	CDD:291396	30/105 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CM8F
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I5129
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D363892at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR31691
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.990