DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ana3 and Rttn

DIOPT Version :10

Sequence 1:NP_610765.1 Gene:ana3 / 36341 FlyBaseID:FBgn0266111 Length:1977 Species:Drosophila melanogaster
Sequence 2:NP_780751.2 Gene:Rttn / 246102 MGIID:2179288 Length:2226 Species:Mus musculus


Alignment Length:2452 Identity:468/2452 - (19%)
Similarity:848/2452 - (34%) Gaps:727/2452 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 GQLTKLTSESEEIRMRALD----QIETRFIRCLQLGEPIQFKPVLLLKQLIRWFGYTPPLVP--D 72
            |.:.||..:..|||.|||.    :||...|....|   ||.:  ||...|:.||.:  |.||  :
Mouse     5 GLIRKLGHQLAEIRERALKSILCKIEHNLICYADL---IQER--LLFLHLLEWFNF--PSVPMKE 62

  Fly    73 RVLAMIMELLRSEYAEAVIRKIPYERFKAELQKVRRVLHKQESKRVSELLDDMNLLLLE------ 131
            .||.::..|::  |:.||...|.....:. |.|:|..:.......:..:||.:.:|..|      
Mouse    63 EVLNLLSRLVK--YSPAVQHLIDLGAVEF-LSKLRPNVEPVIQAEIDGILDGLFILPSEVPALCS 124

  Fly   132 -KYNIDRV----TPSV---------SSLSSNDIP-----SQA----------------TESADSS 161
             .|:.|::    .|.|         |:....::|     :||                |:....|
Mouse   125 SSYHTDQIELSQQPEVLTGYFPQDKSNFQQMEVPPGPAGNQAVKWLRFSVFPWLPLTTTDRHVLS 189

  Fly   162 SNQIYDNLKPEDYEPSWSHPCLDDVATMKSMIDLPRNSVELQLQLTELIIRMGDYPTEYFLQPPF 226
            ||:  .:|:..::...|                   |:.||   |.::|  |.|:|.|.|||.|.
Mouse   190 SNE--SSLRSSNHTLIW-------------------NTCEL---LKDVI--MQDFPAEIFLQRPK 228

  Fly   227 V---FLHLVQLQTMTDGSLIHVNRAL--IACLRLL-------------------QQRILLRRNTL 267
            :   .|.||:|....||.  | ..||  ::||:.|                   :|..:.:.::|
Mouse   229 IVQGLLCLVKLAFGGDGK--H-RLALQSVSCLQQLCTSLRNRLNFYRDPNFFSSRQDTVSQNSSL 290

  Fly   268 SYADRFDPP------------SRP--------------------------------KQVKVVSAL 288
            ||......|            |||                                .::.|.|.|
Mouse   291 SYCHEARGPYHSPNPSPGSSSSRPSVVGRTGQRPRGDGQDWDAVSSSGSSSHTHVNSRISVHSPL 355

  Fly   289 VI----------------------LLENCMKLIR---PLLFSCTNDN-WHIMELIVE-IVRTHDV 326
            .:                      |.:.|:..:.   |||.:.:.:. ..::||:.| ::.....
Mouse   356 DVAPVDLPELEAEDTLELQFQQLSLPQFCISTLEAAAPLLRTGSREMIIRVLELLAEDMLLIGQA 420

  Fly   327 LSSKIPLVSITLIADAVKSLLAYCNSVEGSCMTQLMDSLRIPRLQSLILNGVLHDMVALNIN-YD 390
            :||:| ....:|.|..||..|.......|..|.....|..:.:.::::::   |.|..::|: :.
Mouse   421 ISSEI-WDDNSLFAINVKEKLLQVLGSLGETMCYRKTSFSMEQAEAVLVH---HRMAFVSISLFT 481

  Fly   391 KRMDRRQAKALIQPIVLDSAYLSGMPERMKSLNTLISSLDSGPSPDEELIKLKRAYSVALNQLHP 455
            .|:     ..|:.|:...|.:|   ||.|.:....:|              |....|:...::|.
Mouse   482 VRL-----LQLLLPVEKASEFL---PESMSAALFFVS--------------LDMPISLEYPEIHD 524

  Fly   456 NTELTGSLLIQKYRQVCLVLVQLGSE--TLVKQLFGAV--VKCIPFYAGNLKLRKDADELLYTLV 516
            .              |...|.||.||  ::.|:...||  ::|...:..:  :.|:.::.|..||
Mouse   525 T--------------VVAYLEQLDSENYSIYKRTAEAVYSIECTCNFLSD--VGKEGEKNLLELV 573

  Fly   517 DLPALKLRSLIYRLMIKSTVAHFHSFMNKTVYMTGCSNV--------------DLIRQHILGVPL 567
            :|....|||..|         |.||.:.|.:... ||.:              ..:..|:|..||
Mouse   574 ELADQALRSFSY---------HQHSPLIKEIICI-CSKIWKSAQASPLLQGESQKVFLHMLSHPL 628

  Fly   568 TPLLLRRM-----IIQS--SEANTSERMQQWC-----LDYPIMIMKLNA---------------- 604
            ..:.:...     |::.  ...|.::.:...|     |.:|.::.:::|                
Mouse   629 PQVKVETYQCCLEIVKECLGVQNVTKPVSSLCSGIHFLLHPKVLYEISAFGIQESKNEVNAAAKA 693

  Fly   605 ----------ILAPQDFSVVFPLLLPVLPLLISRSVTHKILHNVIWNVLEPDSSRLDPQL----M 655
                      ::....::.....|.||:|:|...:.|...|.|.|..:.:..|...:..|    .
Mouse   694 ILLYLLQGRLMMTALTWNKFIESLAPVIPVLQGYADTEDPLGNCILLLSKVSSEAGEGALPCTAR 758

  Fly   656 LRGYVYFMFHPDGEVRSEATTTIAYVLQCQEQTNRYLPTASNVPVEHIANDLCIIQPPFCYRSIF 720
            |:..:..:......|||.|...:|:.|..:|..::..|......:..:.| |.|::.|     |.
Mouse   759 LKSVLRLLLVKKPSVRSLALKLLAFHLTSEEGADKKRPFIDAGVLSRVTN-LFIVKKP-----ID 817

  Fly   721 IKCSDERFQGQRSLDALFRLLQAK---------DIKSNIRKSTMTQLNVLLRNWRACEEFSTKED 776
            :|..|.|       :.:.:|...|         |:...:|||...||.|::::.:          
Mouse   818 LKLDDRR-------ELVIKLETVKKVCDIFTSDDVDLVLRKSAAEQLAVIMQDIK---------- 865

  Fly   777 GYRLIMESLHNALKK---------------GNDTDI----LLPTVSILMKLLFNDDEFRLEVANT 822
                    :|..:||               |.|.::    :.|.:::|.|:|:.|...|:.::..
Mouse   866 --------MHTVVKKLCLVEKIIGHLNEFVGQDGEVIECLIQPCLTLLRKVLYADPVIRVSLSQQ 922

  Fly   823 FGVYTLLLRALFLFPHLEQLRQDVSI-----CLFQMLFQNCIT-------STEDKLVLNANMEPL 875
            ..:.|||||...:|      .:|.::     .||.:|..:.::       :..||..|::.....
Mouse   923 ASLLTLLLRVSLIF------HEDCTVVAEVGALFCLLLFDEVSRMDTWSDTLSDKPSLSSVFSLP 981

  Fly   876 I-------LPVTYEIEHKVIPTAV-----TEGLELQQNVEATHFGRDRAKAAQHWRLYMAYRVCQ 928
            :       |||.....|.|.|.::     ||.|.|:.       ..|..:.|  |.|...:....
Mouse   982 VSVFRRYHLPVHVTGHHAVSPYSIVLPLPTECLTLKP-------VSDMLRIA--WNLAWYHGSDN 1037

  Fly   929 VPSSITLESVSALDIRESLKIKMADLALVRSSDLNEQLSCQFIAAENCSKHEDLQKTVSAIQLFL 993
            :...:|.|: ...:..::|::...|:..::.:..:..|.....:......|.|::..::.:..:|
Mouse  1038 LLKQMTSEA-KIQEFLDTLQLSTEDILALKITYTDSGLKDCLQSIIQAGGHRDVRAAITRMSFYL 1101

  Fly   994 VVLRNSLSD-------TVAENLW-KLIHKYIRLAPGNEADDKVYKSMLDLCVTCIRFSQPH-AIN 1049
            :..:.||.|       |:....| .::::::::.|....|:|:...::......|:..:.: :|.
Mouse  1102 LNDKLSLKDDIGPCGVTLKSLAWHTVLNRFLQVLPACTEDEKLLIDIIHFLNKLIKEQRKNPSIE 1166

  Fly  1050 GLSYALETDHHHSFQLLLHDSQISLDKLFL-----------ICQCMMQLLSNELSDDSMNWYGKF 1103
            .|::.||.       ||.|:....||.|.|           :...:.|.|..||. ..:|.....
Mouse  1167 LLNWILEL-------LLRHNPSPLLDLLVLTDSHAGEETDDVRTAVRQQLQKELI-SLLNSLLLV 1223

  Fly  1104 FM--------QLSAVAKTHFELRQLQHVRCILCMLRFVS----ERNL------------------ 1138
            ||        :|..|.:|...|:.||.:| :.....|..    ||.|                  
Mouse  1224 FMTVSDRKCLELFYVFQTQLSLKLLQCLR-VTDAPHFYGLPSLERTLAGMAHLTAFPGWSAHSPL 1287

  Fly  1139 --------KFSNAQLMSYSQHFIQLSSNLRT------STQTGSEWQRDCLYIICQLQI--HLIYQ 1187
                    |:.:..|...:..:::...|..:      :..||          :|.|.:  .:|.|
Mouse  1288 SKPLEICGKYLSGLLEVITSFYVERGGNAMSFMGKGVTKSTG----------LCLLHLSHEMIVQ 1342

  Fly  1188 EPKAS------------SKASIPNDVGASYKVLRYFLTLCGHGDSEVRALSWVSLANWITICGSQ 1240
            .|.:.            |:...|...|     |.:.:.|....|.|||..| :.|.:.:|...:.
Mouse  1343 APGSEWMPLWFLPLGSHSEEHAPTQQG-----LAWLIPLWVDRDPEVRFTS-LGLGSALTTIEAG 1401

  Fly  1241 VAEILPRLDFLPGGLPACCLTTLTDAHEMMLIRELAGRVF--ILLMPL----------------- 1286
            ...:......:.|||....:..|.|..|..|:|..|..:.  :|::|:                 
Mouse  1402 CVALANSCQNISGGLWGTVVNILLDQSECSLVRREAAFILQNLLVIPMPSEIIKDYTWQGPCVHD 1466

  Fly  1287 ------IGAESSLELLRKH--------DLLK-------------------TAYNSLKAIHDTPWM 1318
                  :..:.:|:.|..|        .::|                   :.|:.|..:.|:...
Mouse  1467 EDSGLSLSGKPALQALLYHCRFYEHLTHMVKHCYVGRYIFDFNFSAFTETSEYSDLNGLDDSFKF 1531

  Fly  1319 FKKIVG---ERH------------SCEVISCYV-------------------------------- 1336
            ::...|   :.|            :..|:|..:                                
Mouse  1532 WRAPSGTSTQDHEPSSLSTSETMVAASVVSSEIQPLLPSTLLPETALDQFVTQGQREMRPVRPRD 1596

  Fly  1337 -----AICTKMVAMKPEWCAALCGHSLMSGLSDVMKKLKSQASCSIPLVE-LCASQICELYSMCY 1395
                 ::..:.|.:.|...:|:|  ||:..|..|..:..:.|.....|:| ||::....|..|| 
Mouse  1597 SLLSTSLNRQYVFVTPSLLSAVC--SLLDNLLAVTPRDAANAFQQAHLIELLCSTVDASLIEMC- 1658

  Fly  1396 TNNFEFLKMTI----------CRDSVFLQNYLTLINDVL--------SLECPEYMVIPLLK---M 1439
               .:.||..:          .:.|.||: ||:.::.:|        .|...:.::.||:.   .
Mouse  1659 ---IQELKTPLPLPSAVEHIQAQASFFLE-YLSSLSQLLKSCLLVEPKLVTQDELLKPLITNVIR 1719

  Fly  1440 FLIFCTDSNSNSFLIEQIKNKPSLFMDFF-----LFGLHVKLINSPFQRFTLSALSLVFTKAQLA 1499
            .||.|.....:..|:          :.|:     ||.|...|:..      ..|:|||...:.||
Mouse  1720 VLIVCPKDVLDVQLV----------LAFYRTWTHLFDLLATLLRK------AGAVSLVPLTSALA 1768

  Fly  1500 AYDISMLSELEK-FELAFSDPDIAKDGKQEFESKKKQSVSQCIYDESSDNSDDNKQRPNHA--IQ 1561
            .:..::...|.: ..|:|..|.:.....|.......:...:.:.|:...|..   |.|..|  :.
Mouse  1769 KHWEAVTDTLCRCVGLSFKCPALTIASLQFLSVLLAEEEKRRVQDKDKTNEG---QAPTVALLLD 1830

  Fly  1562 ATNAAIIIFHRLDQLFDRYYLSKALNFLELPAVGQVQVCEALGELLKASTWAVKAAGESKL---- 1622
            .|..::....||::...:.|     ..:....|.:.....||..||..|..|.:.|..|.|    
Mouse  1831 GTQGSLSSSERLNETILQCY-----EGISPKDVLKRVAANALLSLLAVSRRAQRHALRSDLIENC 1890

  Fly  1623 LGKVVHILDDFLNDEKI--GNAAVYVKRVGPHKAQSIISNLLVLINMLSQWHSSPNSEIIQTSMA 1685
            :.::.|| :..||.:.:  |.|.:..|..|..|..||...|  |.|.|.|     |.|....::.
Mouse  1891 MEQMKHI-NAQLNLDLLRPGKAVLKKKEDGFIKELSITMQL--LRNCLYQ-----NEECKVAALE 1947

  Fly  1686 ANIAKILIRIWPWLSHSYHLKKVTVQLIMFLTEHSFEMCKQI------SLLQSGH----AQSLLH 1740
            |.:..:|..:||||.....|.::.:||:...|.:....|..:      ..:|:.|    :.||:.
Mouse  1948 ARLVPVLHSLWPWLLMEDSLMQIALQLLCVYTANFPAGCSSLCWSNYGQCIQTAHRGTPSSSLIL 2012

  Fly  1741 LMARVADFETTKKEIPNKEPSLNMVPALRVMVNCCCCTEGRLSLSKMNLLDMFDTILPANPCSTH 1805
            .:.::|      .::|.:..::..: ....:.|.....:.:..:.|.|.|..|.::......:.|
Mouse  2013 CILKLA------SQMPAENTTIQQL-VFMFLSNLALSHDCKGVIQKSNFLQHFLSLTLPKGGNQH 2070

  Fly  1806 LKVRPPVLIAWL------GFWEVFSRYDVGGKACHLQSLINTIRRSPPLSHKRI--LCLRILRNM 1862
            |..   |.|.||      .|.|     |.......|...::.:.......||..  :.|.|..|:
Mouse  2071 LST---VAILWLKLLLNMSFGE-----DGQQMILRLDGCLDLLIEMSKYKHKSSPHMPLLIFHNI 2127

  Fly  1863 CFFNGNRPRLVELADFINLLRDILEQRVQKAPTSEKNGLNSFEEHRLAVLMLWKLFGFGAKYKGM 1927
            ||...|:|:::.....:.||...||...|.|             .|:....||.|.....|.|..
Mouse  2128 CFSPANKPKILANEKVVTLLAACLESENQTA-------------QRIGAASLWALTYNYQKAKAT 2179

  Fly  1928 LRGTKL-FKLLIGLRVEMSVVFSEEENKYAGVPYANDLAKLLEKLME 1973
            |:...: .|:.....:....:.:.|||     |..:...|.||.|::
Mouse  2180 LKNPSIKRKVDEAYSIAKRTLSNSEEN-----PLNSYYLKCLENLVQ 2221

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ana3NP_610765.1 RTTN_N 25..120 CDD:464283 30/100 (30%)
RttnNP_780751.2 RTTN_N 16..112 CDD:464283 32/105 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 295..346 4/50 (8%)

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