DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8839 and CG7910

DIOPT Version :9

Sequence 1:	NP_610764.1	Gene:	CG8839 / 36340	FlyBaseID:	FBgn0033717	Length:	529	Species:	Drosophila melanogaster
Sequence 2:	NP_001287222.1	Gene:	CG7910 / 40956	FlyBaseID:	FBgn0037547	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	544	Identity:	185/544 - (34%)
Similarity:	283/544 - (52%)	Gaps:	67/544 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 FGILQACIRFVFRLIYGQKGESVPPITDAILLESATSLARKIRKQELSSVQVLESFIRRIKEVNP 80
            ||:|   :..:...:..::......|.:.:|.:|...|..::|:.|::||:::.::|.|::||||
  Fly    15 FGML---VNKILDFVLPRQKPKFSGIRNPLLKKSVVELVTQLRRGEITSVELVSAYIARVQEVNP 76

  Fly    81 ILNCVVDERYDQALKEAAEADALIK--SGQYSTEELEKEKPFLGVPITTKDCISVKGMLHTAGLF 143
            .||.||::|::.||::|..||..|:  |.::....|..:.|.||||.|.|:...:||:....|..
  Fly    77 SLNAVVEDRFEAALQDAKLADQFIEKASSEFDRVALYTKYPILGVPFTVKESCGLKGLSFAVGSL 141

  Fly   144 ERRDVRAARDADAMALMRKAGAIPIALTNVSEVCMWWESNNTVHGRTRNAYDTNRIVGGSSGGEG 208
            .|::::|.:|.|.:.|:|.||.||:.::...|.||.:|::|.:.||..|.||..|...||||||.
  Fly   142 ARKNMKAPQDGDVVELVRAAGGIPLLVSANPEFCMSFETSNNIQGRCLNPYDLQRTSAGSSGGEA 206

  Fly   209 CIQSAAASAFGLGSDIGGSIRMPAFFNGIFGHKPSKLVVSNVGQFPAPFSAEQNSF---LGLGPM 270
            .:....|:.||:||||.||||:||.|.|:|||||:..:.|..|.|  |:|.....|   |.:||:
  Fly   207 SLNGCGATTFGVGSDISGSIRLPALFCGVFGHKPTGGLTSVKGHF--PYSLTDKKFSEMLQIGPI 269

  Fly   271 SRFAEDLRPMLKIMAGEKAALLNLDEDVDLTKMKFFYQESDGGGRLVS--AVDPDLREAMNRVAQ 333
            :|||.||..:|:||||:|...|.:.|.|.|..||.:|.....|...::  .||.|::.|:.:...
  Fly   270 TRFARDLPLLLEIMAGDKKHKLKMSEPVALKDMKVYYAFGYSGFNCLTHPVVDFDIKLAITKAVT 334

  Fly   334 HLREKFGNQKVERIQLPHFRQSAAIWFANM---------------RDDSGHGFAYQLGN--LNHD 381
            .|..  |..:.:::.|...|.|..|...::               ||.|......:|.|  :.|.
  Fly   335 CLER--GGVQSKKLDLKFLRNSLEIALVSLVDLKGLPSIVTQRADRDPSMRLLMVELFNSIIGHS 397

  Fly   382 INT----YLELFKWFFGASKHTFIGLSTAIMDSAQCKHGSPKYDHLVRKRNELREELQSLLGDNG 442
            |.|    .||:.|.|.|.       ::|..|:..:.            :..:::..|..|||..|
  Fly   398 IFTKEAMVLEVMKRFNGL-------MATGNMEEYRV------------EAQKIKSHLNQLLGTQG 443

  Fly   443 VLIYPT-HPTVAPYHNEPITRPINFAYTGI-----VNVLGFPATAVPLGKLGSEGLPLGVQIIAN 501
            |||.|| |.:...:|    |..:|  .|||     .|:||.|||.||:| ....|:|:|:|::|.
  Fly   444 VLIMPTFHTSALCFH----TSLLN--VTGIDNLLLFNILGLPATHVPMG-TNQRGMPIGLQVVAA 501

  Fly   502 FNQDRLCLAVAEELERAFGGWAKP 525
            ..||:|||.||.|||..|.||..|
  Fly   502 QYQDKLCLKVAAELEAVFHGWVPP 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8839	NP_610764.1	GatA	42..525	CDD:223232	180/516 (35%)
CG8839	NP_610764.1	PRK07488	49..520	CDD:236030	176/504 (35%)
CG7910	NP_001287222.1	GatA	41..527	CDD:223232	181/515 (35%)
CG7910	NP_001287222.1	PRK07488	41..525	CDD:236030	180/513 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440861
Domainoid	1	1.000	107	1.000	Domainoid score	I6507
eggNOG	1	0.900	-	-		E1_COG0154
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	142	1.000	Inparanoid score	I4451
Isobase	1	0.950	-	0.69812	Normalized mean entropy	S4795
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D54749at33392
OrthoFinder	1	1.000	-	-		FOG0002245
OrthoInspector	1	1.000	-	-		otm42825
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X256
	11	10.850