Protein Alignment CG8839 and FAAH

DIOPT Version :10

• Sequence 1: NP_610764.1
• Gene: CG8839 / 36340
• FlyBaseID: FBgn0033717
• Length: 529
• Species: Drosophila melanogaster
• Sequence 2: NP_001432.2
• Gene: FAAH / 2166
• HGNCID: 3553
• Length: 579
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 146/541 - (26%)
• Similarity: 229/541 - (42%)
• Gaps: 106/541 - (19%)

  Fly    42 TDAILLESATSLARKIRKQELSSVQVLESFIRRIKEVNPILNCVVDERYDQALKEAAEADALIKS 106
            ::|:|......|.:|:..:||:...||.:::.:..|||...|||.          :..||...:.
Human    71 SEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVT----------SYLADCETQL 125

  Fly   107 GQYSTEELEKEKPFLGVPITTKDCISVKGMLHTAGLFERRDVRAARDADAMALMRKAGAIPIALT 171
            .|...:.|     ..|||::.|:|.:.||...|.||.....|.|..|:..:.:::..||:|...|
Human   126 SQAPRQGL-----LYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHT 185

  Fly   172 NVSEVCMWWESNNTVHGRTRNAYDTNRIVGGSSGGEGCIQSAAASAFGLGSDIGGSIRMPAFFNG 236
            ||.:....::.:|.:.|:|.|.:.:::..||||||||.:..:..|..|||:|||||||.|:.|.|
Human   186 NVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCG 250

  Fly   237 IFGHKPSKLVVSNVGQFPAPFSAEQNSFLGLGPMSRFAEDLRPMLKIMAGEKAALLNLD------ 295
            |.|.||:...:|..|.....:..|... |.:|||:|..|.|...|:.:..|.  :..||
Human   251 ICGLKPTGNRLSKSGLKGCVYGQEAVR-LSVGPMARDVESLALCLRALLCED--MFRLDPTVPPL 312

  Fly   296 ---EDVDLTK--MKFFYQESDGGGRLVSAVDPDLREAMNRVAQHLREKFGNQKVERI--QLPHFR 353
               |:|..:.  ::..|.|:|.    .:...|.:|.|:....|.| |..|:..|..:  .:||..
Human   313 PFREEVYTSSQPLRVGYYETDN----YTMPSPAMRRAVLETKQSL-EAAGHTLVPFLPSNIPHAL 372

  Fly   354 QSAAIWFANMRDDSGHGFAYQ---------LGNLNHDINTYLELFKWFFG----ASKHTFIGLST 405
            ::.:.  ..:..|.||.|...         ||    |:.:.|:|.:|..|    ..|.....||.
Human   373 ETLST--GGLFSDGGHTFLQNFKGDFVDPCLG----DLVSILKLPQWLKGLLAFLVKPLLPRLSA 431

  Fly   406 AIMDSAQCKHGSPKYDHLVRKRNELREELQ----SLLG-----DNGVLIYPTHPTVAPY--HNEP 459
            .:.:......|         |..||:.|::    :::.     |..|::   .|.:||.  .|.|
Human   432 FLSNMKSRSAG---------KLWELQHEIEVYRKTVIAQWRALDLDVVL---TPMLAPALDLNAP 484

  Fly   460 ITRPINFAYTGIVNVLGFPATAVPL----------------------------GKLGSEGLPLGV 496
            .......:||.:.|.|.|||..||:                            |...|.|||:.|
Human   485 GRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAV 549

  Fly   497 QIIANFNQDRLCLAVAEELER 517
            |.:|...|:.|||....|:||
Human   550 QCVALPWQEELCLRFMREVER 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8839	NP_610764.1	GatA	49..525	CDD:439924	144/534 (27%)
FAAH	NP_001432.2	Amidase	95..562	CDD:396144	135/507 (27%)